Comparative Study in Early Neonates with Septicemia by Blood Culture, Staining Techniques and C – Reactive Protein (CRP)

Dhanalakshmi,; Es, Sivakumar

doi:10.7860/jcdr/2015/12437.5725

Cited by 7 publications

(5 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Of that, 6% showed positive for Klebsiella species, which was comparable to the study by Madavi et al, and Jiang et al, study showed positive for E. coli in 8% cases, which was comparable to the study by Jiang et al, and Lancet Global-DeNIS collaboration. [13][14][15] The present study showed sensitivity of CRP-90%, which was comparable to the study by Dhanlakshmi et al, Negative predictive value was 95%, which was comparable to the study by Galhotra et al 5,16 Present study showed total leucocyte count had low sensitivity of 20%, which was comparable with the study by Rimon et al, and Hasan et al 7,17 Present study showed Absolute neutrophil count had a low sensitivity (20%) and a specificity of 97.5% which was comparable to Hasan et al 7 Study showed Thrombocytopenia had a sensitivity of 60% and specificity of 45%, comparable with Hasan et al 7 Sensitivity and negative predictive value in our study was 100% which was comparable to the study by Kocabas et al, carried out in the year 2007. 18…”

Section: Discussionsupporting

confidence: 89%

“…microcephaly, anencephaly, other neural tube defects etc., 4 • Neonates who have received antibiotics before admission. 5 After obtaining institutional ethics committee clearance and written informed consent (Annexure I), the outpatients in the department of medicine fulfilling the inclusion and exclusion criteria will be enrolled in the study.…”

Section: • Inborn Errors Of Metabolismmentioning

confidence: 99%

“…These indirect markers will help detect neonatal sepsis earlier which will enable the clinician to treat the infection timely and thus it will help to reduce neonatal morbidity and mortality. 5 Septic markers that will be considered in this study will be: CRP considered positive if >1mg/dl., Total leukocyte count (TLC) (leukopenia): <5000 cells/cumm., ANC (neutropenia): <1800 cells/cumm., PC (thrombocytopenia): <1.5 lakhs/cumm.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Study to correlate sepsis markers and blood culture in neonatal sepsis

Swamy

Lakshmi

Mallesh

et al. 2020

Int J Contemp Pediatr

View full text Add to dashboard Cite

Background: Neonatal sepsis forms the second most common cause of neonatal mortality resulting in more than one million neonatal deaths per year. Neonatal sepsis, pneumonia and meningitis together result in one- fourth of all newborn deaths. Objectives of the study was to correlate sepsis markers with blood culture in neonatal sepsis.Methods: A cross sectional study was carried out in the NICU unit under department of Pediatrics, between November 2017 and May 2019. Sample size was 50. Babies admitted to NICU with clinical suspicion of sepsis were included in the study. Blood samples from these babies were collected under aseptic precautions and subjected to rapid diagnostic tests- sepsis markers and blood culture.Results: Male were predominant (64%). Important risk factors were preterm and low birth weight. Blood culture positivity was 20% (E. coli being most commonly isolated organism). CRP had a high sensitivity of 90% and low specificity of 47%. Procalcitonin had highest sensitivity of 100% and low specificity of 47.5%.Conclusions: CRP and PCT were found to be statistically significant (p=0.036 and 0.01), can be used as a diagnostic tool in neonatal sepsis.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: • Inborn Errors Of Metabolismmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Study to correlate sepsis markers and blood culture in neonatal sepsis

Swamy

Lakshmi

Mallesh

et al. 2020

Int J Contemp Pediatr

View full text Add to dashboard Cite

show abstract

“…51% and 52.1% of our patients in clinically suspected and culturally positive septicaemic neonates were low birth weight (<2500 g). Similar to El Badawy et al (11) , El-Din et al (18) , and Dhanalakshmi & Sivakumar (23) as they found 69.7%, 75.5% and 65% of their patients < 2.5 kg . In contrast to Adatara et al (16) , they found that the majority (77.7%) of their neonates had normal birth weight above 2.5 kg.…”

Section: Discussionsupporting

confidence: 80%

Microbiological pattern of Neonatal Sepsis in Aswan University Hospital: hospital based study

2021

Aswan University Medical Journal

View full text Add to dashboard Cite

Background: Neonatal sepsis is still considered as one of the major causes of morbidity and mortality in neonates. Objective: This study aimed to estimate the prevalence, microbiological pattern, and antibiotic susceptibility of neonatal sepsis in the Neonatal Intensive Care Unit (NICU) in Aswan University Hospital (AUH) in a specific time. Methodology: The study was a prospective cross-sectional study carried out on all neonates admitted to the NICU with suspected neonatal sepsis a from August 2017 to July 2018. All neonates were subjected to history, examination, and investigations which included complete blood count, Creactive protein, and blood cultures at the time of presentation. Results: Our study included 100 neonates with suspected neonatal sepsis. Positive growth in blood culture was 23% of cases. Isolated organisms were 11% S. aureus, 7% K. Pneumonia and 5% Enterobacter cocci. Antibiotic sensitivity revealed that the three organism were sensitive to Ciprofloxacin. All cases were resistant to Erythromycin and Gentamycin. About 8.6% were leucopenic, 38% had leukocytosis and 95.7 % had high CRP. Conclusion: This study revealed increasing rate of neonatal sepsis with high degree of antibiotic resistance to commonly used antibiotics among both gram-positive and gram-negative isolates.

show abstract

“…Any type of congenital anomalies e.g., tracheoesophageal fistula, malrotation of the gut, lobar agenesis, complex heart diseases, microcephaly, anencephaly (10,11). Hydrops, neonates with administration of antibiotic at admission, refusal of parental consent and samples from LAMA / abscond patients were excluded from the study.…”

Section: Exclusion Criteriamentioning

confidence: 99%

Assessment of C-reactive protein, procalcitonin and interlukin-6 as diagnostic aid for neonatal infections at a tertiary care center

et al. 2021

View full text Add to dashboard Cite

Introduction and Aim: Neonatal infections are the leading cause of mortality among neonates after prematurity. The importance determining biological markers to be used as a diagnostic test to detect neonatal infections the in early stage of the disease is a challenge. The purpose of this study was to evaluate the usefulness & sensitivity of various serological markers such as serum Procalcitonin, C-reactive protein and chemokine IL-6 for diagnosis of neonatal infections leading to sepsis in new born infants. Materials and Methods: This cross-sectional study was carried out among newborns admitted in neonatal intensive care unit (NICU) and meeting the selection criteria. Samples were collected for blood culture and ELISA was performed for detection of CRP, PCT & IL-6. Results: A total of 300 newborns were included in this study from NICU of which 132 (44%) neonates was found to be blood culture positive. The most frequently isolated organisms were Klebsiella pneumoniae (26.5%), followed by Candida albicans (18.1%). In case of confirmed neonatal sepsis, significant higher levels of CRP, PCT and IL-6 were detected than in cases of probable sepsis. Serum procalcitonin levels exhibit highest sensitivity and specificity as 65.91% and 91.67% respectively. Conclusion: Serum procalcitonin has better diagnostic utility in terms of biological marker for the diagnosis of neonatal infections than C- reactive protein and Interleukin-6.

show abstract

Comparative Study in Early Neonates with Septicemia by Blood Culture, Staining Techniques and C – Reactive Protein (CRP)

Cited by 7 publications

References 8 publications

Study to correlate sepsis markers and blood culture in neonatal sepsis

Study to correlate sepsis markers and blood culture in neonatal sepsis

Microbiological pattern of Neonatal Sepsis in Aswan University Hospital: hospital based study

Assessment of C-reactive protein, procalcitonin and interlukin-6 as diagnostic aid for neonatal infections at a tertiary care center

Contact Info

Product

Resources

About