Comparative study of aryl halides in Pd-mediated reactions: key factors beyond the oxidative addition step

Abstract

The comparative experimental study of Ar–X (X = Cl, Br, I) reactivity and analysis reported herein suggest that oxidative addition cannot be considered the sole reason of the observed low reactivity of aryl chlorides.

Evidence for the “cocktail” nature of platinum-catalyzed alkyne and alkene hydrosilylation reactions

“…Nanoparticles were sampled from solutions by the nanofishing technique reported previously. 68,69 The trap was a carbon coating on a 3.05 mm copper grid for transmission electron microscopy (TEM). After reaction completion, the leached nanoparticles were captured from the reaction solution obtained by centrifugation of the reaction mixture and filtration by using a PTFE membrane filter with a pore size of 0.45 μm.…”

Reactions’ Descriptors Selection and Yield Estimation Using Metaheuristic Algorithms and Voting Ensemble

“…Without the aryl halide, no reaction will be prompted, and the palladium catalyst assists in the instantaneous reaction. Other factors, such as oxidative addition, also influence aryl halides' reactivity [40]. Base and additives are also crucial in a reaction as well as aryl halide and the catalyst.…”

Mechanistic Aspects of the Palladium‐Catalyzed Suzuki‐Miyaura Cross‐Coupling Reaction

“…Thus, these ancillary ligands contribute to the catalytic process owing to their electronic and steric properties by facilitating the oxidative addition of less reactive aryl halides, [67] and increasing the rate of the reductive elimination. Additives such as olefins with electron‐withdrawing substituents were demonstrated to promote the activation of the catalyst [68] .…”