Comparative study of assisted reproductive outcomes between young patients with occult premature ovarian insufficiency and advanced-age patients

Yao, Lingnv; Lin, Wenqin; Jiang, Nan; Li, Chuyan; Cao, Haifeng; Li, Hong; Qian, Jiang

doi:10.1177/0300060520934656

Cited by 3 publications

(1 citation statement)

References 30 publications

(61 reference statements)

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“…For patients with POI undergoing ART, the ultimate goal is to obtain as many mature eggs as possible, although this goal is difficult to achieve and there is no consensus as to which protocol is optimal for this population. Compared to young women with a diminished ovarian reserve, older women with normal ovarian function had a higher embryo implantation rate, but there was no significant difference in live birth rates between the groups, suggesting a discrepancy in egg quality (19). To obtain maximal oocytes and embryos for patients with POI, many studies attempted to explore the optimal ovulation-stimulation protocols.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy outcomes in women with primary ovarian insufficiency in assisted reproductive technology therapy: a retrospective study

Sun,

Li,

Zhang

et al. 2024

Front. Endocrinol.

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PurposeThis study aims to retrospectively estimate cumulative reproductive outcomes in women with primary ovarian insufficiency (POI) in assisted reproductive technology (ART) therapy.MethodsA total of 139 patients diagnosed with POI were reviewed in this study. Firstly, they were divided into two groups according to oocyte origin: using their own oocytes (OG group) or accepting oocyte donations (OD I group). Secondly, the patients were split depending on the pregnancy outcome. In the OG group, nine patients decided to use others’ oocytes after a failure of attempting to use their own, and this population was the oocyte donation II group (OD II group).ResultsThere were 88 patients who used their own oocytes, while 51 patients accepted oocyte donations. In the OG group, there are only 10 (7.2%) patients who got pregnant, and patients in the OD group had worse hormone levels (FSH 71.37 ± 4.18 vs. 43.98 ± 2.53, AMH 0.06 ± 0.04 vs. 1.15 ± 0.15, and AFC 0.10 ± 0.06 vs. 1.15 ± 0.15) and more years of infertility (5.04 ± 0.48 vs. 3.82 ± 0.30), which explained why they choose oocyte donation. In all the three groups, baseline characteristics were comparable between pregnant women and non-pregnant women. Of the 10 pregnant patients in the OG group, four of them used luteal-phase short-acting long protocol and had pregnancies successfully in their first cycles.ConclusionOvarian stimulation in POI women requires more cost and time. For those with a stronger desire to have genetic offspring, luteal-phase short-acting long protocol may help them obtain pregnancy rapidly.

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Section: Discussionmentioning

confidence: 99%

Pregnancy outcomes in women with primary ovarian insufficiency in assisted reproductive technology therapy: a retrospective study

Sun,

Li,

Zhang

et al. 2024

Front. Endocrinol.

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Comparison of ART outcome in patients with poor ovarian response according to POSEIDON criteria

Lee

Noh²,

Joo

2022

Sci Rep

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The aim of this study is to evaluate whether the patient-oriented strategies encompassing individualized oocyte number (POSEIDON) criteria can reflect the prognosis of controlled ovarian stimulation (COS) by comparing the results of assisted reproductive technologies (ART) between four POSEIDON and normal responder (NR) groups. In total, 225 patients were included in this retrospective observational study. The patients underwent various COS protocols and in vitro fertilization or intracytoplasmic sperm injection, followed by fresh or frozen embryo transfer. Based on their clinical and demographic data, patients were divided into four groups according to the POSEIDON classification, and their ART outcomes were evaluated. Statistical analyses were performed using R version 4.0.5, and a p-value of < 0.05 was considered significant. The NR group had the highest number of total oocytes retrieved and total embryos obtained, as well as the best ART outcome in terms of clinical pregnancy rate ([CPR], 47.6%). The POSEIDON groups 1 and 2 had better COS and ART outcomes than groups 3 and 4 (CPR, 22.6%, 22.1%, 16.7%, and 4.8% in groups 1–4, respectively); the patients in group 3 were younger than those in group 2 by definition, but their CPR was lower than that of patients in group 2. When comparing young and old women with low anti-Müllerian hormone (AMH) levels, the younger group (POSEIDON group 2) had better COS and ART outcomes than their older counterparts, especially POSEIDON group 4. A binary logistic regression adjusted for body mass index (BMI) comparing the ART outcomes of patients that did not get pregnant in the POSEIDON groups compared to the NR group showed odds ratios (ORs) (95% confidence interval) of 2.938 (1.496–5.768), 3.376 (1.848–6.167), 6.801 (2.740–16.881), and 20.497 (8.284–50.713) for groups 1, 2, 3, and 4, respectively. Ovarian reserve still seems to outweigh patients’ age when predicting the ART outcomes of low-responder infertile women, as suggested by the results of POSEIDON groups 2 and 3. However, when there are no differences in ovarian reserve, as in POSEIDON groups 2 and 4, younger women with low AMH have a higher probability of pregnancy than their AMH-matched older counterparts.

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Effect of Icariin on the Number of Follicles and Endometrium Thickness in Mice with Premature Ovarian Failure

Li,

Xiao,

Wang

et al. 2024

Clin. Exp. Obstet. Gynecol.

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Background: This study explored icariin’s effects on endometrial thickness and follicle numbers in mouse models of premature ovarian failure (POF). Methods: We divided 8-week-old C57BL/6J female mice into five groups: NC (control), CTX (cyclophosphamide-induced POF), CTX-ICA (CTX-induced POF with icariin), OVX (ovariectomy-induced POF), and OVX-ICA (ovariectomy-induced POF with icariin). We monitored estrous cycles and assessed endometrial thickness and follicle counts using Hematoxylin & Eosin (H&E) staining. Results: CTX and OVX reduced estrous activity, and the CTX-ICA group exhibited higher activity. Compared with NC, the primary follicles were decreased in the CTX group (p = 0.005) but not in the CTX-ICA group (p = 0.272). Endometrial thickness was respectively thinner in the OVX and OVX-ICA vs. CTX-ICA, CTX, and NC groups (p < 0.001); the CTX vs. NC (p < 0.001) groups; and the CTX vs. CTX-ICA groups (p < 0.001). No significant differences were found between the CTX-ICA and NC groups (p = 0.972). Conclusions: In conclusion, CTX and OVX induce POF in mice, causing endometrial thinning and decreased follicles (CTX). Icariin may partly restore endometrial thickness.

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Comparative study of assisted reproductive outcomes between young patients with occult premature ovarian insufficiency and advanced-age patients

Cited by 3 publications

References 30 publications

Pregnancy outcomes in women with primary ovarian insufficiency in assisted reproductive technology therapy: a retrospective study

Pregnancy outcomes in women with primary ovarian insufficiency in assisted reproductive technology therapy: a retrospective study

Comparison of ART outcome in patients with poor ovarian response according to POSEIDON criteria

Effect of Icariin on the Number of Follicles and Endometrium Thickness in Mice with Premature Ovarian Failure

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