2010

DOI: 10.5551/jat.1354

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Comparative Study of Atherosclerotic Parameters in Mongolian and Japanese Patients with Hypertension and Diabetes Mellitus

Shuumarjav Uurtuya

¹

,

Kazuhiko Kotani

²

,

Nobuyuki Taniguchi

³

et al.

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Discussion3

Perspective On Cavi Research1

What Is Cavi ? What Is the Outlook Of Cavi A Marker Of Arter1

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Cited by 13 publications

(13 citation statements)

References 23 publications

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“…In contrast, IMT failed to show associations with clot structure parameters. The discrepancy between ABI and IMT is not unprecedented and can be explained by the relatively weak correlation between these vascular parameters, which can be influenced by the IMT measurement taken (18,19). In addition to vascular factors, low eGFR and smoking were associated with deleterious effects on clot structure, supporting previous findings (11,20) and suggesting additional prothrombotic effects for impaired renal function and smoking in diabetes.…”

Section: Discussionsupporting

confidence: 69%

Gender-Specific Alterations in Fibrin Structure Function in Type 2 Diabetes: Associations with Cardiometabolic and Vascular Markers

¹

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²

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³

et al. 2012

The Journal of Clinical Endocrinology &Amp; Metabolism

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Women with type 2 diabetes have compact clots with compromised fibrinolysis compared with men. There are gender-specific associations between clotting parameters and cardiometabolic risk factors in this population, whereas vascular abnormalities, impaired renal function, and smoking are associated with prothrombotic clot structure profile regardless of gender.

“…In contrast, IMT failed to show associations with clot structure parameters. The discrepancy between ABI and IMT is not unprecedented and can be explained by the relatively weak correlation between these vascular parameters, which can be influenced by the IMT measurement taken (18,19). In addition to vascular factors, low eGFR and smoking were associated with deleterious effects on clot structure, supporting previous findings (11,20) and suggesting additional prothrombotic effects for impaired renal function and smoking in diabetes.…”

Section: Discussionsupporting

confidence: 69%

Gender-Specific Alterations in Fibrin Structure Function in Type 2 Diabetes: Associations with Cardiometabolic and Vascular Markers

¹

,

²

,

³

et al. 2012

The Journal of Clinical Endocrinology &Amp; Metabolism

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Women with type 2 diabetes have compact clots with compromised fibrinolysis compared with men. There are gender-specific associations between clotting parameters and cardiometabolic risk factors in this population, whereas vascular abnormalities, impaired renal function, and smoking are associated with prothrombotic clot structure profile regardless of gender.

“…In addition, the CAVI was developed in Japan, and most studies have been conducted in Japanese people. Our prior race-based studies have revealed differences in the CAVI levels between Japanese and Mongolian subjects, and it is possible that the genetic differences and environmental factors (i.e., altitude) are involved in this difference [20,21]. Comparative studies using many ethnicities will be therefore be required before this index can be used outside of Japan.…”

Section: Perspective On Cavi Researchmentioning

confidence: 93%

Clinical Significance of the Cardio-Ankle Vascular Index (CAVI) in Hypertension

2010

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Increased blood pressure and hypertension are a major atherosclerotic risk factor. Arterial stiffness is recognized to be reflective to the atherosclerotic states. The pulse wave velocity (PWV) is a noninvasive, simple, easy and reproducible index that can be used to assess arterial stiffness in association with blood pressure. The cardio-ankle vascular index (CAVI) has recently been developed to evaluate arterial stiffness similarly to PWV, but theoretically, this index is less influenced by blood pressure. There have been several clinical reports on the use of the CAVI in patients with hypertension. The CAVI levels are reported to be significantly and positively correlated with the ultrasonographical atherosclerotic parameters of carotid arteries, as a surrogate marker of atherosclerotic events, in hypertensive patients. Intervention studies of anti-hypertensive therapy using CAVI have shown that candesartan, olmesartan and efonidipine can improve the CAVI levels. These results suggest that the CAVI is clinically helpful for the assessment of atherosclerotic risk and the management with drug treatment in patients with hypertension. However, compared with PWV, there is not much evidence of using CAVI in a clinical setting; future research is therefore necessary.

“…Compared with this study, differences in CAVI values in the present study are small, which may be partially due to the different impact of lifestyle and genetic differences between the Japanese and Chinese populations, in addition to methodological differences. The CAVI values of patients with hypertension and diabetes mellitus have been compared between Mongolian and Japanese populations, and the Mongolian CAVI values were higher than those of the Japanese 40,41) . In the present study, mean CAVI values of the Amami subjects were similar to those of the healthy Japanese population in males, and lower in females.…”

Section: Discussionmentioning

confidence: 99%

Values of Cardio-Ankle Vascular Index (CAVI) between Amami Islands and Kagoshima Mainland Among Health Checkup Examinees

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²

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³

et al. 2012

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Aim:To investigate the prevalence and geographical variation of high arterial stiffness in groups from the Amami islands (Amami) and Kagoshima mainland (mainland), Japan, using the cardio-ankle vascular index (CAVI) as a surrogate marker of arterial stiffness. Methods: We recruited 4,523 health checkup examinees from Amami and 440 examinees from the mainland, with an age range of 40-69 years. The frequency of high arterial stiffness (CAVI ≥ 9.0) was geographically compared between the regions, and both mean CAVI values were compared with those of the healthy Japanese population with less risk factors for coronary artery disease. Clinical, lifestyle, and regional factors for increased CAVI values were estimated by the multiple linear regression model. Results: The frequency of high arterial stiffness on Amami was significantly lower than on the mainland. Mean CAVI values on Amami were similar in males and lower in females than in the healthy Japanese population, but those on the mainland were higher for both sexes. Age, systolic blood pressure, triglycerides, fasting blood glucose, and a history of hypertension and diabetes mellitus were positively related to increased CAVI values on Amami. The regional factor of Amami, compared with the mainland, was negatively related to increased CAVI values in both sexes after adjusting for traditional cardiovascular risk factors. Conclusion: CAVI values in Amami residents were significantly lower than in mainland residents, suggesting that environmental or genetic factors might have improved arterial stiffness in the Amami population.

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