1980
DOI: 10.1093/bja/52.3.291
|View full text |Cite
|
Sign up to set email alerts
|

Comparative Study of Atropine and Glycopyrrolate on Suxamethonium-Induced Changes in Cardiac Rate and Rhythm

Abstract: The effectiveness of atropine and glycopyrrolate in the prophylaxis of suxamethonium-induced bradycardia was evaluated in a double-blind study of 56 patients. Three had clinically demonstrable bradycardia, all having received atropine. We conclude that glycopyrrolate offered adequate protection against cardiac effects of repeated doses of suxamethonium.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

0
8
0
1

Year Published

1981
1981
2006
2006

Publication Types

Select...
8
1

Relationship

1
8

Authors

Journals

citations
Cited by 22 publications
(9 citation statements)
references
References 5 publications
0
8
0
1
Order By: Relevance
“…Heart rate has been used as an index of the vagal blocking action of anticholinergic drugs. This is an important consideration in children who require frequent administration of suxamethonium or who undergo squint surgery (Leigh et al, 1957;Cozanitis, Dundee and Khan, 1980). Heart rates of children in the oral atropine group were significantly slower than the rates for the other groups, suggesting a less effective vagal blocking action.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Heart rate has been used as an index of the vagal blocking action of anticholinergic drugs. This is an important consideration in children who require frequent administration of suxamethonium or who undergo squint surgery (Leigh et al, 1957;Cozanitis, Dundee and Khan, 1980). Heart rates of children in the oral atropine group were significantly slower than the rates for the other groups, suggesting a less effective vagal blocking action.…”
Section: Discussionmentioning
confidence: 99%
“…Glycopyrrolate (Robinul) is a recently introduced quaternary ammonium anticholinergic agent with powerful and prolonged antisialagogue activity (Mirakhur, Dundee and Jones, 1978). Although a number of studies report its use as preanaesthetic medication in adults (Mirakhur et al, 1978;Cozanitis, Dundee and Khan, 1980;Sengupta, Gupta and Pandey, 1980), little information exists on its efficacy in paediatric patients.…”
mentioning
confidence: 99%
“…could have been prevented had a potent antimuscarinic drug such as glycopyrrolate been given i.v. just before start of anaesthesia (Cozanitis, Dundee and Khan, 1980). The results of this investigation suggest that "special handling" of Sx (methods II and III) do not offer any advantages over the injection of tubocurarine 0.05 mgkg" 1 3min before the administration of Sx l.Smgkg" 1 for controlling the sequelae of i.v.…”
Section: Discussionmentioning
confidence: 83%
“…흡입마취제인 halothane과 enflurane을 이용한 마취에서 나 타나는 atropine, glycopyrrolate 20) 및 pancuronium Propofol 마취 시에는 혈압이 감소하는 경우에도 심박수가 증가하지 않고, 동성 서맥(sinus bradycardia), 7,8) 방실 전도 차단 (atrioventricular conduction block), 9,10) 심박동 정지(asystole)…”
Section: 마취유도 전 Enflurane군의unclassified