Comparative study of biphasic calcium phosphate with beta-tricalcium phosphate in rat cranial defects—A molecular-biological and histological study

Bone Regeneration after Treatment with Covering Materials Composed of Flax Fibers and Biodegradable Plastics: A Histological Study in Rats

“…All surgical procedures were performed according to standard protocol. This protocol has been published several times [27, 36, 38–40]. …”

“…In order to compare the data obtained with the molecular-biological findings [35] the skulls were dissected four weeks after composite insertion and fixed in 4% PBS-buffered formalin, dehydrated in a graded series of alcohol, and separately embedded in methylmethacrylate (Technovit 9100 neu, Kulzer, Germany) as previously described [41–44] or in paraffin after decalcification as previously described [40, 45]. …”

“…Image analysis was performed on composed pictures showing the complete cavity with a magnification of ×100 as previously described [40, 47] using the software cell ∧ F (analySIS Image Processing Olympus, Münster, Germany). From each skull a minimum of 10 sections were histomorphometrically analysed.…”

Dose effects of beta-tricalcium phosphate nanoparticles on biocompatibility and bone conductive ability of three-dimensional collagen scaffolds

“…Many previous investigators have reported that β-TCP possesses good osteoconductivity and degradability as a bone graft material when implanted into the bone tissue. They also reported that β-TCP phagocytosis provides calcium ions for osseous induction following osteoblast proliferation [45][46][47] . As described above, TCP25 strongly induced release of calcium ions, irrespective of macrophage phagocytosis.…”

Interrelationship between bone substitution materials and skeletal muscle tissue

“…Furthermore, the biocompatibility of a scaffold or matrix for a tissue engineering product refers to the ability to perform as a substrate that will support the appropriate cellular activity, including the facilitation of molecular and mechanical signaling systems, in order to optimize tissue regeneration, without eliciting any undesirable local or systemic responses in the eventual host (Williams, 2008). The tissue response to biomaterials depends on a variety of factors, including the physical-chemical properties of the implant, reactivity (bioactive or inert), surface texture, biodegradability/bioresorbability, as well as the duration and site of implantation (Pieper et al, 2000;Burugapalli and Pandit, 2007;Kunert-Keil et al, 2013). It is well known that bone can influence muscle function and muscle function can influence bone structures.…”