Comparative Study of Cellulose Tris(3-chloro-5-methylphenylcarbamate) Coated or Covalently Immobilized on Silica for the Separation of Enantiomers in High-Performance Liquid Chromatography

Khatiashvili, Tamar; Matarashvili, Iza; Karchkhadze, Marina; Farkas, Tivadar; Chankvetadze, Bezhan

doi:10.1007/s10337-023-04295-8

Chromatographia

2023

DOI: 10.1007/s10337-023-04295-8

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Comparative Study of Cellulose Tris(3-chloro-5-methylphenylcarbamate) Coated or Covalently Immobilized on Silica for the Separation of Enantiomers in High-Performance Liquid Chromatography

Tamar Khatiashvili,

Iza Matarashvili,

Marina Karchkhadze

et al.

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2025

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Cited by 2 publications

References 41 publications

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Enhanced enantioselective separation of racemic menthol via reverse-phase high-performance liquid chromatography: Method development and computational insights for pre-screening

Mao,

Zhou,

et al. 2025

Talanta

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Enhanced enantioselective separation of racemic menthol via reverse-phase high-performance liquid chromatography: Method development and computational insights for pre-screening

Mao,

Zhou,

et al. 2025

Talanta

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The Application of Polysaccharide Chiral Columns for the Separation of Fluorinated and Protonated Liquid Crystalline Racemic Esters

Wojda,

Urbańska

2024

Separations

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The subject of this study was to compare the enantioseparation of fourteen racemic esters that are liquid crystals. This study aimed to determine the difference in the enantioseparation of mixtures with protonated and fluorinated aliphatic chains and those with different orders of occurrence of benzene rings (benzoates and biphenylates). This research was carried out on two chiral polysaccharide columns: amylose tris(3-chloro-5-methylphenylcarbamate) (ReproSil Chiral MIG) and cellulose tris(3,5-dichlorophenylcarbamate) (ReproSil Chiral MIC). The columns were evaluated in HPLC separation. The analyses were performed in the normal- and reversed-phase systems. The mobile phase consisted of different solvent systems (acetonitrile/water and n-hexane/2-propanol) in different volume ratios to select optimal separation conditions. The main parameter evaluated in separating racemic mixtures was the resolution—Rs. All measurements were performed at 25 °C. The elution order was also determined. The highest value of resolution (over 11) and selectivity (over 3) was obtained for the ReproSil Chiral MIG column and the volume ratio of ACN:H2O (95:5 v/v).

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Comparative Study of Cellulose Tris(3-chloro-5-methylphenylcarbamate) Coated or Covalently Immobilized on Silica for the Separation of Enantiomers in High-Performance Liquid Chromatography

Cited by 2 publications

References 41 publications

Enhanced enantioselective separation of racemic menthol via reverse-phase high-performance liquid chromatography: Method development and computational insights for pre-screening

Enhanced enantioselective separation of racemic menthol via reverse-phase high-performance liquid chromatography: Method development and computational insights for pre-screening

The Application of Polysaccharide Chiral Columns for the Separation of Fluorinated and Protonated Liquid Crystalline Racemic Esters

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