Comparative study of collagenase and papain-urea based preparations in the management of chronic nonhealing limb ulcers

Vijaykumar, Hosamath

doi:10.17485/ijst/2011/v4i9.14

Cited by 6 publications

(3 citation statements)

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“…There are many methods of slough removal, namely sharp or surgical debridement, biological, mechanical or chemical. 5,6 A range of chemical agents, including hypochlorites such as EUSOL and Dakin's Solution (sodium hypochlorite), hydrogen peroxide and iodine have been used to promote debridement of wounds. One trial comparing enzymatic debridement with salinesoaked dressings reported that the enzyme-treated wounds were cleaned more quickly.…”

Section: Introductionmentioning

confidence: 99%

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Effect of papain urea versus hydrogen peroxide in diabetic foot ulcer management

Rakesh

Jose

2023

Int Surg J

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Background: Diabetic foot ulcers are the most common complications in diabetic patients. Debridement of an ulcer play a vital role in the healing of diabetic foot ulcers. Medical methods of debridement have an advantage as it is also painless and can be done on OPD basis. Aim of this study was to compare the effectiveness of debridement using papain urea dressing as against hydrogen peroxide in diabetic foot ulcer management. Methods: Patients who have a diabetic foot ulcer reporting to the hospital were studied using either hydrogen peroxide or papain urea dressings. All were brought under adequate glycemic control. Emperically oral antibiotics are started to all patients and changed according to culture and sensitivity reports after three days. Patients was randomly allocated to receive either H2O2 or papain urea dressings, 63 per set. Statistical analysis was done using the SPSS software. Significance level was fixed at p value of p<0.05. Results: It was seen that PAPAIN UREA ointment is a better agent in debridement when compared to hydrogen peroxide. All 63 patients started showing features of reduction in ulcer size and area of slough. This difference was statistically significant. Conclusions: In diabetic foot ulcer, papain urea dressings help in wound healing by decreasing the duration of healing time and by faster slough removal. It promotes granulation, without any complications. Hence papain urea dressings are a good option for debridement and wound healing in diabetic foot ulcer.

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Section: Introductionmentioning

confidence: 99%

“…This study was done to compare two chemical debridement agents, namely Hydrogen peroxide and papain-urea combination. 5,6 Papain, obtained from papaya fruit breaks down cysteine residues in proteins. Urea is combined to increase its proteolytic action.…”

Section: Introductionmentioning

confidence: 99%

Effect of papain urea versus hydrogen peroxide in diabetic foot ulcer management

Rakesh

Jose

2023

Int Surg J

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“…Uma vez que tal ação não é seletiva, a maioria das proteínas que contém resíduos de cisteína, incluindo os fatores de crescimento, sofre a ação da papaína. [14][15][16][17][18][19][20][21][22] O colágeno não sofre tal ação por não possuir resíduos de cisteína. 15,16,19 A ureia, por sua vez, tem a função de facilitar a ação proteolítica da papaína, ou seja, ela expõe ativadores da papaína no tecido necrótico, pela alteração da estrutura tridimensional das proteínas, interrompendo a ligação de hidrogênio.…”

Section: Introductionunclassified

Papaína-Ureia Como Agente Desbridante: Revisão De Literatura

Araújo

Silva

Carmona

et al. 2015

Rev. baiana de saúde pública

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A remoção do tecido inviável da ferida é um passo importante para o processo de cicatrização. O desbridamento enzimático é um dos métodos utilizados pela equipe de enfermagem para tal fim, consistindo na aplicação de enzimas exógenas no leito da ferida, a fim de obter a degradação do tecido necrosado, sem prejuízo do viável. Dentre os produtos disponíveis para tal desbridamento, a associação papaína-ureia apresenta resultados satisfatórios. Entretanto, ainda é pouco utilizada no Brasil. Assim, o presente estudo é uma revisão de literatura, cujo objetivo foi identificar artigos científicos sobre o uso da papaína-ureia como agente desbridante em feridas. A busca se deu nas seguintes bases de dados: PubMed, Scopus, Web of Science, Cochrane, LILACS e SciELO. O período considerado foi de 2000 a 2012, utilizando os descritores: desbridamento, papaína-ureia, papaína, ureia e suas respectivas versões em inglês. De acordo com a literatura, o uso de papaína-ureia promove dissolução do tecido não viável e melhora a aparência da lesão: ocorre redução de edema, eritema, odor e exsudato. Favorece, assim, o processo de granulação e epitelização. Entretanto, as evidências científicas ainda são poucas e mais estudos precisam ser realizados.

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Study of the keratin-based therapeutic dermal patches for the delivery of bioactive molecules for wound treatment

Nayak

Gupta

2017

Materials Science and Engineering: C

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Comparative study of collagenase and papain-urea based preparations in the management of chronic nonhealing limb ulcers

Cited by 6 publications

References 0 publications

Effect of papain urea versus hydrogen peroxide in diabetic foot ulcer management

Effect of papain urea versus hydrogen peroxide in diabetic foot ulcer management

Papaína-Ureia Como Agente Desbridante: Revisão De Literatura

Study of the keratin-based therapeutic dermal patches for the delivery of bioactive molecules for wound treatment

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