Comparative study of copper(II)–curcumin complexes as superoxide dismutase mimics and free radical scavengers

The Molecular Basis for the Pharmacokinetics and Pharmacodynamics of Curcumin and Its Metabolites in Relation to Cancer

“…1C) (Cotton and Wilkinson, 1980). Accordingly, curcumin forms chelates with metals such as boron (Mohri et al, 2003;Rao and Aggarwal, 2008), copper (Baum and Ng, 2004;Barik et al, 2007;Zebib et al, 2010;Addicoat et al, 2011), aluminum (Jiang et al, 2011), magnesium (Zebib et al, 2010), zinc (Zebib et al, 2010), lead (Daniel et al, 2004), cadmium (Daniel et al, 2004), and ferrous (Fe 2+ ) and ferric (Fe 3+ ) iron (Tønnesen and Greenhill, 1992;Borsari et al, 2002;Baum and Ng, 2004;Bernabe-Pineda et al, 2004b;Ak and Gulcin, 2008;Dairam et al, 2008), but also with metal oxides such as vanadyl (Thompson et al, 2004) and nonmetals such as selenium (Zebib et al, 2010). Although the majority of experimental data indicate that the metal cations bind the oxygens of the b-diketo moiety (Borsari et al, 2002;Zebib et al, 2010; (D S , bottom structure) of enolic curcumin are plotted on the axes, all connected by a color-coded single trace.…”

Synthesis and Characterization of some Ternary Metal Complexes of Curcumin with 1,10-phenanthroline and their Anticancer Applications

“…The strong chelating ability of diketones has been widely investigated towards a great number of metal ions; therefore, curcumin could be of great importance in the chelating treatment of metal intoxication and overload [10]. The formation of various metal complexes with curcumin has been investigated [10][11][12]. The stoichiometries of curcumin with some metal ions were also reported [10,12].…”

“…The formation of various metal complexes with curcumin has been investigated [10][11][12]. The stoichiometries of curcumin with some metal ions were also reported [10,12]. Several metal complexes of curcumin have been synthesized, characterized and evaluated for various biological activities.…”

Palladium Complex Containing Curcumin as Ligand: Thermal and Spectral Characterization

“…In almost all work reported in literature, complexes of curcumin formed is of the type ML 2 where the metallic ion has electrical charge +2, and complex of the type ML 3 , when the ion metallic has electrical charge +3 [10][11][12][13][14][15]. Many these complexes were evaluated for various biological activities and very interesting results have been reported [15][16][17][18][19][20][21]. An interesting example refers to a palladium complex containing bypyridine and curcumin, that induces both cell growth inhibition as apoptosis of human prostate cancer cells (LnCaP, PC3, and DU145), through the production of ROS and JNK phosphorylation associated with GSTp1 down regulation [22].…”