Comparative Study of Different Biological Glues in an Experimental Model of Surgical Bleeding in Anesthetized Rats: Platelet-Rich and -Poor Plasma-Based Glue with and without Aprotinin versus Commercial Fibrinogen-Based Glue

Sirieix, D.; Chemla, Eric S.; Castier, Yves; Massonnet-Castel, S; Fabiani, Jean‐Noël; Baron, J. F.

doi:10.1007/s100169900160

Cited by 17 publications

(10 citation statements)

References 19 publications

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“…Various experimental studies have been set up to analyze this aspect; for instance, in liver bleeding after laparoscopy, commercial fibrinogenbased glue has been compared with platelet-rich and platelet-poor plasma-based glue with and without aprotinin [2]. The commercial fibrin glue was shown to be more efficient than the other medications, likely due to a higher fibrinogen concentration in this product [2].…”

Section: Introductionmentioning

confidence: 98%

Comparative efficacy of different doses of fibrin sealant to reduce bleeding after total knee arthroplasty

Notarnicola¹,

Moretti²,

Martucci³

et al. 2012

Blood Coagulation &Amp; Fibrinolysis

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In recent years, the application of fibrin sealant has been shown to be efficacious in the management of intraoperative and postoperative hemostasis. We designed a prospective randomized controlled clinical trial to assess the efficacy of two different dosages of fibrin sealant (5 and 10 ml) in patients undergoing total knee arthroplasty, as compared with the untreated control group. A total of 90 patients entered the study, randomly assigned to one of the three groups: treatment with 5 ml fibrin sealant (30 patients), with 10 ml fibrin sealant (30 patients) or no treatment (30 patients). A statistically significant difference in the mean reduction of hemoglobin concentrations was found on the first postoperative day in the treated groups as compared with the controls: 5 ml fibrin sealant (2.6 mg/dl) and 10 ml fibrin sealant (2.5 mg/dl) vs. controls (3.7 mg/dl) (P = 0.024). The mean number of blood transfusions was significantly lower in the treated groups: 5 ml (0.5) and 10 ml (0.3) of fibrin sealant vs. controls (1) (P = 0.0019). Functional recovery was also better in the treated groups: on the seventh day, the joint ROM (range of motion) was statistically superior in the 5 ml group (96.5°) and 10 ml group (98.8°) as compared with the controls (75.5°) (P < 0.0001). This study supports the efficacy of administering fibrin sealant in the perioperative management of bleeding after total knee arthroplasty and shows that a 5 ml dosage yields a comparable outcome to the 10 ml dosage previously reported in the literature.

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Section: Introductionmentioning

confidence: 98%

Comparative efficacy of different doses of fibrin sealant to reduce bleeding after total knee arthroplasty

Notarnicola¹,

Moretti²,

Martucci³

et al. 2012

Blood Coagulation &Amp; Fibrinolysis

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“…However, few comparative studies have been undertaken to date [5,9]. In the current study, we compared the physical properties of two conventional non-autologous fibrin sealants (prepared from lyophilised fibrinogen and thrombin) with an autologous fibrin sealant, Vivostat (prepared from individual blood donations and free from added thrombin).…”

Section: Discussionmentioning

confidence: 99%

Physical Characteristics of Vivostat<sup>®</sup> Patient-Derived Sealant

Velada

Hollingsbee²

2001

Eur Surg Res

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This study compared the physical characteristics of Vivostat^® patient-derived sealant with two conventional fibrin sealants, Tissucol^® and Beriplast^®. Vivostat sealant exhibited greater elasticity without compromising tensile strength. Vivostat sealant polymerised at low temperatures (4 and 25°C) or at high temperature (70°C) exhibited similar viscoelastic properties as when polymerised at normal physiological temperature (37°C). Vivostat fibrin I solution can be stored at room temperature for up to 8 h without affecting the mechanical properties of the derived sealant. These physical characteristics of Vivostat patient-derived sealant suggest that it may have suitable stability and performance characteristics for use in a wide range of surgical procedures.

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“…The sealing capability of various surgical glues has been studied and used by many researchers and clinicians [20]- [22]. The threat of getting infection from agents of the fibrin adhesive limits the widespread usage of the surgical glue in surgery, especially in the United States.…”

Section: ) Surgical Gluementioning

confidence: 99%

Radioactive seed immobilization techniques for interstitial brachytherapy

et al. 2008

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Let us know how access to this document benefits you Methods: We first analyze the possible causes for seed movement, and propose three potential techniques for seed immobilization: (1) surgical glue, (2) laser coagulation and (3) diathermy coagulation. The feasibility of each method is explored. Experiments were carried out using fresh bovine livers to investigate the efficacy of seed immobilization using surgical glue. Results:Results have shown that the surgical glue can effectively immobilize the seeds.Evaluation of the radiation dose distribution revealed that the non-immobilized seed movement would change the planned isodose distribution considerably; while by using surgical glue method to immobilize the seeds, the changes were negligible.Conclusions: Prostate brachytherapy seed immobilization is necessary and three alternative mechanisms are promising for addressing this issue. Experiments for exploring the efficacy of the other two proposed methods are ongoing. Devices compatible with the brachytherapy procedure will be designed in future.

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Comparative Study of Different Biological Glues in an Experimental Model of Surgical Bleeding in Anesthetized Rats: Platelet-Rich and -Poor Plasma-Based Glue with and without Aprotinin versus Commercial Fibrinogen-Based Glue

Cited by 17 publications

References 19 publications

Comparative efficacy of different doses of fibrin sealant to reduce bleeding after total knee arthroplasty

Comparative efficacy of different doses of fibrin sealant to reduce bleeding after total knee arthroplasty

Physical Characteristics of Vivostat<sup>®</sup> Patient-Derived Sealant

Radioactive seed immobilization techniques for interstitial brachytherapy

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