Comparative Study of Different Histologic Classifications in the Degree of Differentiation in Endometrial Adenocarcinoma

Silva-Filho, Agnaldo L.; Xavier, Érica B.S.; Cândido, Eduardo Batista; Macarenco, Ricardo; Ferreira, Mariana Costa; Xavier, Marcelo Antônio Pascoal; Maciel, Rayra Amana Macêdo; Vidigal, Paula Vieira Teixeira

doi:10.5301/tj.5000528

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“…Histopathological assessment of the EC differentiation degree was conducted referring to the International Federation of Gynecology and Obstetrics grading system of EC. Briefly, an endometrial glandular component area corresponding to >95%, 50% to 94%, and <50% neoplasm was classified as well-, moderate-, poor-differentiated EC, respectively, with corresponding cellular atypia 14 …”

Section: Methodsmentioning

confidence: 99%

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Endometrial microbiota from endometrial cancer and paired pericancer tissues in postmenopausal women: differences and clinical relevance

et al. 2022

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Objectives: Assess acceptability of a 12-minute educational video before menopause clinic consultation and evaluate its impact on knowledge and treatment certainty.Methods: This was a pre-post intervention study among new patients with vasomotor symptoms (VMS) referred to a menopause clinic in Toronto, Canada. Participants completed electronic questionnaires before and after viewing a 12-minute online video covering menopause facts and VMS treatments. Participants' demographic information and referring provider type were recorded. A 19-item true/false knowledge quiz and validated Decision Conflict Scale (DCS) were administered before and after viewing the video along with a validated Acceptability questionnaire after the video. Demographic information and acceptability were summarized descriptively and independent samples t tests compared knowledge and DCS total and subscores before and after viewing the education module. Multivariable analysis was used to identify factors associated with achieving treatment certainty.Results: Seventy-one participants completed pre-and postintervention questionnaires. Mean age was 51.4 ± 6.0 years and most were White (58/71, 81.7%), had a university degree (24/71, 63.3%) and household income >$90,000 (53/71, 74.6%). After the video, there was significant increase in knowledge score (12.7 ± 2.1 vs. 16.9 ± 1.8, P < 0.001) and decrease in all DCS scores (total and five subscores) compared with preintervention scores ( P < 0.001). Acceptability was high with 62/71 (87.3%) respondents indicating the tool was useful. Findings were independent of level of education, household income, and referring physician type.Conclusion: In a study of predominantly university-educated White women, a 12-minute education module on menopause and VMS treatment was acceptable, there was improved knowledge and decision certainty about VMS treatment.

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Section: Methodsmentioning

confidence: 99%

“…Briefly, an endometrial glandular component area corresponding to >95%, 50% to 94%, and <50% neoplasm was classified as well-, moderate-, poor-differentiated EC, respectively, with corresponding cellular atypia. 14 Tissue Sample Processing, DNA Extraction, and Sequencing…”

Section: Participant Profilesmentioning

confidence: 99%