Comparative Study of Differentiation Levels and Valepotriate Content of in Vitro Cultures and Regenerated and Wild Plants of Valeriana edulis ssp. procera

Abstract

Valepotriate content levels in samples of in vitro cultures of Valeriana edulis ssp. procera were compared with those of roots and rhizomes of wild plants in the reproductive stage. Rhizomes and roots of regenerated and wild plants showed a similar valepotriate content. The data obtained support the hypothesis that valepotriate production in V. edulis spp. procera is closely related to rhizome and root differentiation. The large-scale propagation of this endangered plant may offer an attractive alternative for its production for medicinal purposes.

Neuropharmacological profile of hydroalcohol extract of Valeriana edulis ssp. procera roots in mice

“…It is well known that barbiturates interact with the GABA Abenzodiazepine receptor complex, so it could suggest a direct or indirect action on this binding site by components of the V. edulis extract (Hendriks et al, 1985). A previous report described a sedative and an enhanced pentobarbital effect of valerenic acid isolated from V. officinalis (Hendriks et al, 1985), however, it has been reported that valerenic acid is absent in V. edulis (Castillo et al, 2002) and that the valepotriates concentration is higher that those found in other Valeriana species (Bos et al, 1998). Dihydroisovaltrate is the main valepotriate in V. edulis hydroalcohol extract (HerreraArellano et al, 2001).…”

“…procera was obtained by culture in a micropropagation technique (Enciso-Rodríguez, 1997). It has been reported that variations in active compounds from micropropagation plants were much less than seed propagated plants (Gao and Bjork, 2000;Castillo et al, 2002). It suggests that using micropropagation could be an interesting and advantageous alternative for obtaining active compounds.…”

Role of Light and Medium Composition on Growth and Valepotriate Contents in Valeriana glechomifolia Whole Plant Liquid Cultures

“…Valepotriates also have been shown to have antifungal (Fuzzati et al 1996) and cytotoxic (Bounthanh et al 1981;Bos et al 1998a) activities. As an alternative to obtain these active compounds of pharmaceutical interest, some species have been investigated: V. officinalis, cultivated in Europe on a large scale (Bos et al 1998b); V. wallichii, native to the Himalayas (Mathur et al 1988), and V. edulis originated from Central America (Castillo et al 2002).…”

Mexican Medicinal Plants Used to Alleviate the Symptoms of Anxiety: Mini-Review

“…Both the European and Mexican Valerian species have similar effects on CNS. It was described the sedative and enhanced pentobarbital effect of valerenic acid isolated from V. officinalis [37], but it has been reported that valerenic acid is absent in Mexican V. edulis [38] and the valepotriates concentration is higher in comparison with other Valeriana species [39]. Dihydroisovaltrate is the main valepotriate in V. edulis hydroalcohol extract [40].…”