Comparative study of effect of Withania somnifera as an adjuvant to DOTS in patients of newly diagnosed sputum smear positive pulmonary tuberculosis

Kumar, Ranjeet; Rai, Jaswant; Kajal, Nirmal Chand; Devi, Pushpa

doi:10.1016/j.ijtb.2017.05.005

Cited by 17 publications

(9 citation statements)

References 19 publications

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“…There was average gain in body weight in Ashwagandha treated group with improved quality of life. There was significant difference in hepatic enzymes than placebo group with possible hepato-protection [22] .…”

Section: Ashwagandha: Integrative Management Of Tuberculosismentioning

confidence: 79%

Ashwagandha: Potential Integrative Management of Tuberculosis

Bandale

Baheti

2020

ijirms

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The World Health Organization TB (Tuberculosis) statistics for India for 2018 give an estimated incidence of 2.69 million cases.TB is being a challenge for India and worldwide developing countries pre and post antitubercular drug era. The major limitations clinicians face in management of TB is its MDR, immunosuppression, bad prognosis during course of treatment and associated side effects of anti- tubercular drugs putting patient in danger for multiple organ failure. The presence of comorbidities, nutritional deficiencies add up toll in the whole clinical presentation of tuberculosis management. There is very systematic pathophysiology and treatment ideology explained in Ayurveda for tuberculosis and related respiratory infections. There is great need to integrate Ayurveda wisdom of understanding tuberculosis and medicinal herbs in protective mode with aggressive targeted anti TB activity of modern medicine. Ashwagandha is strong Rasayana category medicinal plants with ancient references for its beneficial effect in management of tuberculosis also supported by modern day in vitro, in vivo and clinical evidences of effectiveness of Ashwagandha in management of tuberculosis could be ray of hope. There should focused research aimed at unfolding mechanisms and clinical guidelines for the use of Ashwagandha as an adjuvant in themanagement of tuberculosis.

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Section: Ashwagandha: Integrative Management Of Tuberculosismentioning

confidence: 79%

Ashwagandha: Potential Integrative Management of Tuberculosis

Bandale

Baheti

2020

ijirms

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“…A docking study has shown that Withania somnifera can weaken the neuraminidase of the H1NI virus ( Cai et al, 2015 ). Ranjeet Kumar et al (2018) has reported the effectiveness of using Withania somnifera as an adjuvant to enhance the immune system of patients with pulmonary tuberculosis in combination with the DOTS therapy.…”

Section: Current Covid Treatment In India and Why There Is A Need For Alternative Therapymentioning

confidence: 99%

Evidence-based traditional Siddha formulations for prophylaxis and management of respiratory symptoms in COVID-19 pandemic-a review

Prakash

Meena

Stanley

et al. 2021

Biocatalysis and Agricultural Biotechnology

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The recent outbreak of COVID-19 is attributed to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). This viral disease is rapidly spreading across the globe, including India. The mainstay in managing the disease is supportive care, nutrition, and preventing further progression in the absence of proven antiviral drugs. Currently two vaccines Covishield and Covaxin are administered in India. Long-term plans of developing most reliable mRNA-based vaccines are also underway for the future method of prophylaxis. The Siddha system of medicine’s holistic approach emphasizes lifestyle modification, prophylactic interventions, and dietary management to boost the host immunity and treatment with herbal medicines and higher-order medicines as the case may be. In this review, a brief outline of the disease COVID-19, Coronavirus, evidence-based traditional Siddha interventions for respiratory ailments, immune boosters highlighting the relevant published research on individual herbs are dealt, which pave way for further research on drug repurposing for COVID-19. Historical evidence on the prevention and treatment of infections in Siddha classics is studied. Web search in databases such as Embase, Biomed Central Articles, Pub med, NLM, Web of Science CrossRef, Google scholar, AYUSH research portal, google search engine related to antiviral properties of herbs used in the preparation of Siddha drugs was also carried out.

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“…Periyaka ruppan et al, 2012 29 Sarepaka a et al, 30 Ranjeet Kumara et al, 2017 31 Davis L et al, 2000 32 Agarwal R et al, 1999 33…”

Section: Withania Somniferamentioning

confidence: 99%