Comparative Study of Efficacy of Topical Minoxidil 5% and Combination of Topical Minoxidil 5%, Topical Azelaic Acid 1.5% and Topical Tretinoin 0.01% on the Basis of Dermoscopic Analysis in Androgenetic Alopecia

Abstract

Background: Androgenetic alopecia (AGA) more commonly known as male pattern baldness affects up to 50% of men worldwide. Tretinoin prolongs anagen phase and increases percutaneous absorption of minoxidil three fold. Azelaic acid is an inhibitor of 5 alpha reductase and could be an effective agent in the treatment of androgen related pathology of human skin. Aims and Objective: 1) To study the efficacy of topical minoxidil 5% in treatment of androgenetic alopecia. 2) To study the efficacy of combination of topical minoxidil 5%, topical azelaic acid 1.5% and topical tretinoin 0.01% in treatment of androgenetic alopecia. 3) To compare the efficacy of foresaid topical preparation in treatment of androgenetic alopecia Setting: Outpatient department of Dermatology, Venerology Leprology of a tertiary health care centre with an attached medical college. Material and methods: Topical minoxidil 5 % lotion was used in 23 (50%) patients of the present study. Combination of topical minoxidil 5%, azelaic acid 1.5 % and tretinoin 0.01 % lotion was used in 23 (50 %) patients of the present study. Statistical analysis used: Epi info version 7. Results: There was statistically significant increase in hair number and thickness after treatment in both the groups. The comparison of the increase of hair number and thickness was statistically insignificant. Conclusions: Topical Minoxidil 5% is equally effective to combination of topical Minoxidil 5%, azelaic acid 1.5% and tretinoin 0.01% in treatment of androgenetic alopecia.

Formulation of Sodium Valproate Nanospanlastics as a Promising Approach for Drug Repurposing in the Treatment of Androgenic Alopecia

“…A valuable insight into the patient diagnosis and treatment could be attained when the results of these techniques are interpreted with a comprehensive clinical picture. More recent studies reported that the use of dermoscopy of scalp and hair in the clinical assessment of hair disorders could provide a higher diagnostic capability than simple clinical examination [ 91 , 92 , 93 ]. Figure 11 and Figure 12 illustrate the clinical photographs and the dermoscopic pictures of group A and group B, respectively.…”

The Effect of the Fractional Carbon Dioxide Laser on Improving Minoxidil Delivery for the Treatment of Androgenetic Alopecia

“…1 Topical minoxidil is commonly used in the treatment of AGA; it prolongs the anagen growth phase and gradually develops miniaturized follicles (vellus hairs) into mature terminal hairs. 2 In the last few years, the use of lasers in treating hair loss has well developed through many means. The paradoxical hair growth noticed after laser hair removal is a clinical example of photo-induced hair growth.…”

“…The continuation of the treatment is required to keep the profit. 2 Recently, laser treatment for hair loss has become very popular; it has also been promoted as a preventative measure against AGA as there is evidence that laser light stimulates hair growth at some wavelengths. 3 Laser-assisted drug delivery (LAD) is an evolving technology with potentially broad clinical applications.…”