Comparative study of frontal QRS-T angle and inflammatory parameters in obsessive compulsive disorder patients and healthy control group

Abstract

It is argued that the average life expectancy for obsessive-compulsive disorder (OCD) decreases. However, data on the reasons for this are limited. This study compared sociodemographic characteristics, electrocardiogram (ECG) parameters, and laboratory values of 56 patients diagnosed with OCD with 60 healthy controls. We aimed to interpret the risk of cardiovascular disease in OCD through ECG parameters. OCD patients and the control group did not differ statistically in age or gender (p=0.689 and p=0.756, accordingly). Patient's with OCD have significantly longer corrected QT interval (QTc) (p=0.001). In comparison to the control group, OCD patients had statistically greater frontal QRS-T angle (fQRS-T) (p=0.044). The levels of platelet-to-lymphocyte ratio (PLR), pan immune inflammation value (PIV), and systemic immune inflammation index (SII) were elevated significantly in OCD patients (p=0.001, p=0.002, and p=0.009, respectively). The monocytes to high-density lipoprotein cholesterol (HDL-C) ratio (MHR) and atherogenic index of plasma (AIP) values of OCD patients were significantly greater than those of the control group (p<0.001 and p=0.006). Based on the Receiver Operating Characteristic (ROC) analysis, MHR had the highest area under curve (AUC) value (AUC=0.699, p<0.001, cut-off=0.0097). It was determined that a 0.0097 increase in MHR value could be used in diagnosing OCD with 66% sensitivity and 71% specificity. According to the results of our study, cardiovascular mortality can be predicted by measuring fQRS-T in the electrocardiogram or AIP and MHR values in laboratory findings in OCD patients, and treatments and recommendations can be made in this regard. Calculating MHR and fQRS-T can also be used in routine practice because it is inexpensive and easy to apply. It seems possible that clinicians can reduce mortality and morbidity in this patient group by examining these parameters more in routine practice.

Pre- and post-treatment evaluation of routine blood analysis in patients with attention deficit hyperactivity disorder and comparison with the healthy control group

“…ROC analysis revealed that these parameters had significant diagnostic values for ADHD, as indicated by the determined cut-off values. These findings are consistent with a study conducted by Abus et al, which reported higher SII and PIV levels in patients with obsessive–compulsive disorder compared to the control group 13 .…”

“…The results of the present study are consistent with some previous studies. For example, Abus et al reported higher SII and PIV levels in patients with obsessive–compulsive disorder, which aligns with the findings of the present study 13 . Similarly, Akıncı & Uzun found elevated neutrophil, PLT, and NLR levels in the ADHD group, supporting the results of the present study 1 .…”

“…Nitric oxide, arginase, and reactive oxygen species released in the presence of high SII may play a role in the development of ADHD by inhibiting activated T cells 12 . It has been found that PIV ((platelet count x neutrophil count x monocyte count)/lymphocyte count) is high in obsessive–compulsive disorder 13 .…”

Investigation of hemogram and biochemistry parameters in non-alcoholic fatty liver disease

“…Neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), monocyte lymphocyte ratio (MLR), uric acid albumin ratio (UAR), monocyte high-density lipoprotein cholesterol (HDL-C) ratio (MHR), atherogenic index of plasma (AIP) were analyzed. AIP was calculated by taking the logarithm of the triglyceride ratio to HDL-C [4].…”

Comparison of Cardiovascular Disease Risk Indicators in Bipolar Disorder Patients with Healthy Controls

“…The electrocardiogram (ECG) easily measures this brand-new DOI: 10.37990/medr.1232186 measure. The available evidence suggests that frontal QRS-T might be a cardiovascular disease marker (7). The ECG sign of a scar in the myocardium is the fragmented QRS (fQRS).…”