Comparative study of garlic species (Allium sativum and Allium porrum) on glucose uptake in diabetic rats

Belemkar, Sateesh; Dhameliya, Kalpesh; Pata, M.

doi:10.1016/j.jtumed.2013.04.002

Cited by 9 publications

(6 citation statements)

References 21 publications

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“…In this respect, Liu et al (2005) have reported that garlic oil decreased blood glucose and improved the glycaemic control system in diabetic rats through increased insulin secretion and insulin sensitivity. This support our results a mechanism of action of garlic as a hypoglycemic agent was extensively discussed by (Belemkar et al, 2013) who found that possible inhibition of glucose transmit by garlic is due to the increased utilization of glucose by the gut wall which resulted in reduction of glucose transported into the serosal solution.…”

Section: Blood Parameters and Immunity Response Of Nzw Rabbitssupporting

confidence: 91%

Blood Biochemical and Immunological Responses to Garlic Oil Administration in Growing Rabbits Diet

El-Gogary¹,

Mansour²,

El-Said³

2017

JAS

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The effect of dietary supplementation garlic oil on performance and blood parameters of New Zealand White rabbits has been studied. The garlic oil was added at graded levels of 0.0, 0.25, 0.5 and 0.75 g/kg for T1 (control), T2, T3 and T4, respectively. A total of thirty six male rabbits, 7 weeks of age and with an initial weigh of 950 g were used. There were four treatments, each with three replicates (n = 3) in randomly divided design. The parameters investigated were growth performance, carcass yield, glucose, plasma lipids profile, immunoglobulin’s G (IgG, IgA and IgM), antioxidant status and testosterone hormone. The results showed that feeding diet supplemented with garlic oil had insignificant effect on body weight, body weight gain, feed intake, feed conversion ratio, triglycerides, cholesterol, LDL and HDL. Rabbits fed the 0.5 g/kg garlic oil diet had significantly increased IgG level, hence improved immune responses and Testosterone hormone of rabbits. The colony forming units of coliform bacteria showed a significantly lower number compared with control. The present results indicate that supplemented of garlic oil at 0.5 g/kg of diet has a positive effect on HDL, immunoglobulin’s G, antioxidant status and testosterone hormone in addition to its antibacterial effect.

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Section: Blood Parameters and Immunity Response Of Nzw Rabbitssupporting

confidence: 91%

Blood Biochemical and Immunological Responses to Garlic Oil Administration in Growing Rabbits Diet

El-Gogary¹,

Mansour²,

El-Said³

2017

JAS

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“…[ 36 ] Garlic also decreases serum glucose by limiting glucose absorption from the intestine. [ 37 ]…”

Section: Discussionmentioning

confidence: 99%

The Effect of Garlic (Allium Sativum) on Polycystic Ovary Syndrome Related Hormones and Glycemic Parameters: A Randomized, Double-Blinded Clinical Trial

Zadhoush,

Alavi-Naeini,

Feizi

et al. 2023

International Journal of Preventive Medicine

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Background: The purpose of the present study was to investigate the effect of garlic supplementation on androgen levels and glycemic-related markers in patients with PCOS. Methods: In these 8 weeks of randomized double-blinded control trial, 80 women were randomly assigned into two groups in which patients were asked to intake either 800 mg/day garlic or an identical placebo. A blood sample was obtained pre- and post-trial to assess androgens and glycemic-related parapets. A 3-days- food record and a short form of international physical activity questionnaires (IPAQ) were also evaluated at the beginning and end of the trial. Results: All participants completed the trial. Garlic supplementation resulted in significant reduction in fasting plasma glucose (-3.22 ± 7.41 vs. 0.72 ± 5.37; P = 0.008) and homeostatic model assessment for insulin resistance (HOMA-IR) (-0.29 ± 1.45 vs. 0.28 ± 1.20; P = 0.02). In addition, a trend to a significant improvement was detected in free androgen index (FAI) ( P = 0.09), insulin levels ( P = 0.07), and quantitative insulin sensitivity check index (QUICKI) ( P = 0.06). However, no significant difference was found in testosterone and sex hormone-binding globulin (SHBG) ( P > 0.05). Conclusions: Present study indicates that garlic supplementation could be beneficial for FPG and insulin resistance improvement. However, garlic supplementation does not show remarkable efficacy on androgens. Further studies are warranted to confirm the results.

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“…Furthermore, several papers reported the hypoglycemic activity of garlic is attributed to sulfur compounds, such as DATS and others: diallyl disulfide (DADS), diallyl sulfide (DAS), alliin, allicin and ajoene, due to their free -SH group [23,24]. Decreased blood glucose levels after garlic consumption might be explained by the diminution of glucose absorption from the gastrointestinal tract by garlic and its active compounds [25].…”

Section: Discussionmentioning

confidence: 99%

Garlic Derived Diallyl Trisulfide in Experimental Metabolic Syndrome: Metabolic Effects and Cardioprotective Role

Jeremić

Jakovljević

Živković

et al. 2020

IJMS

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This study aimed to examine the effects of diallyl trisulfide (DATS), the most potent polysulfide derived from garlic, on metabolic syndrome and myocardial function in rats with metabolic syndrome (MetS). For that purpose, we used 36 male Wistar albino rats divided into control rats, rats with MetS and MetS rats treated with 40 mg/kg of DATS every second day for 3 weeks. In the first part, we studied the impact of DATS on MetS control and found that DATS significantly raised H2S, decreased homocysteine and glucose levels and enhanced lipid and antioxidative, while reducing prooxidative parameters. Additionally, this polysulfide improved cardiac function. In the second part, we investigated the impact of DATS on ex vivo induced ischemia/reperfusion (I/R) heart injury and found that DATS consumption significantly improved cardiodynamic parameters and prevented oxidative and histo-architectural variation in the heart. In addition, DATS significantly increased relative gene expression of eNOS, SOD-1 and -2, Bcl-2 and decreased relative gene expression of NF-κB, IL-17A, Bax, and caspases-3 and -9. Taken together, the data show that DATS can effectively mitigate MetS and have protective effects against ex vivo induced myocardial I/R injury in MetS rat.

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Comparative study of garlic species (Allium sativum and Allium porrum) on glucose uptake in diabetic rats

Cited by 9 publications

References 21 publications

Blood Biochemical and Immunological Responses to Garlic Oil Administration in Growing Rabbits Diet

Blood Biochemical and Immunological Responses to Garlic Oil Administration in Growing Rabbits Diet

The Effect of Garlic (Allium Sativum) on Polycystic Ovary Syndrome Related Hormones and Glycemic Parameters: A Randomized, Double-Blinded Clinical Trial

Garlic Derived Diallyl Trisulfide in Experimental Metabolic Syndrome: Metabolic Effects and Cardioprotective Role

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