Comparative study of gold and silver interactions with amino acids and nucleobases

Abstract

Our calculations showed that amino acids stabilize gold nanoclusters; binding energy between organics and gold is higher than between organics and silver.

Chiral Recognition on Bare Gold Surfaces by Quartz Crystal Microbalance

“…The LOD values for Cys enantiomers were almost the same value and lower than those of the other two amino acids. Since ‐SH group in Cys could chemically react with Au [31, 32] . It thus may strengthen the binding of Cys on the Au surface, rendering higher sensitivity for adsorption but worse selectivity for enantiomers [33] .…”

“…Ser and Cys showed relatively lower adsorption difference between D‐ and L‐enantiomers than the case of Phe (Figure 3 a), which means that the sensing efficiency of Ser and Cys is lower than Phe. As no recognition group existed on the surface, the specific interactions should be mainly due to coordination bonding between the amino acids and Au [31, 34, 35] . The benzene group in Phe may strengthen the adsorption on metal surface due to the π‐electron interaction, [36] which may facilitate to induce larger difference of binding conformations for Phe enantiomers [37] …”

Chiral Recognition on Bare Gold Surfaces by Quartz Crystal Microbalance

“…Ser and Cys showed relatively lower adsorption difference between D-and L-enantiomers than the case of Phe (Figure 3a), which means that the sensing efficiencyo fS er and Cys is lower than Phe.Asnorecognition group existed on the surface,t he specific interactions should be mainly due to coordination bonding between the amino acids and Au. [31,34,35] Thebenzene group in Phe may strengthen the adsorption on metal surface due to the p-electron interaction, [36] which may facilitate to induce larger difference of binding conformations for Phe enantiomers. [37] Although the adsorption sensitivities of various amino acids are different, it is interesting to find that D-type enantiomers are preferred to adsorb for all cases.B ased on the frequency shifts upon 5-minute adsorption, the D-/Lenantioselectivity a value of Phe was 2.1, while that of Ser and Cys was 1.7 and 1.5, respectively.…”

“…[28][29][30] Forthe case of Phe,itisabout 0.083 mM for L-Phe and 0.041 mM for D-Phe,r espectively.T he LOD values for Cys enantiomers were almost the same value and lower than those of the other two amino acids.S ince -SH group in Cys could chemically react with Au. [31,32] It thus may strengthen the binding of Cys on the Au surface,r endering higher sensitivity for adsorption but worse selectivity for enantiomers. [33] From the comparison of frequency shift upon adsorption time,t he adsorption difference of D-and L-Cys was inclined to decrease with prolonging adsorption time or increasing the concentration of Cys (Figure S9 and S10).…”

First principles study of the optical response of Au8 cluster conjugated with methionine, tryptophan, and tryptophyl‐methionine dipeptide

“…It is worth mentioning that despite the recent advances in the synthesis of gold nanoclusters in biological media, [ 6 ] the investigation of the preferred amino acid residues for binding with Au is still an ongoing process. [ 29 ] For example, the amino and carboxylic groups have been reported as the favored anchoring sites with Au clusters both experimentally and theoretically. [ 30,31 ] However, the interaction of Au clusters with thiol‐containing biomolecules indicated strong electronic interactions between Au and thiol group.…”