1967
DOI: 10.1002/1097-0142(196711)20:11<1934::aid-cncr2820201122>3.0.co;2-4
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Comparative study of histologic and chromosomal abnormalities in cervical neoplasia

Abstract: The chromosome patterns of 124 cases of cervical intraepithelial neoplasia (dysplasia and carcinoma in situ) and 87 cases of invasive carcinoma of the cervix were examined with the direct squash technique. Diploid or near diploid modes occurred exclusively in the dysplasias. Heteroploidy occurred in both carcinoma in situ and invasive carcinoma but the majority of cases of carcinoma in situ exhibited near tetraploid modes whereas the majority of invasive carcinomas had modes in the near diploid range. These di… Show more

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Cited by 61 publications
(6 citation statements)
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“…Cells containing integrated high-risk HPV acquire a strong growth advantage over cells harbouring episomal high-risk HPV and undergo clonal expansion. These cells also show increased genomic instability [30,31] and therefore have a greater probability of acquiring the secondary genomic abnormalities that may drive malignant progression [32].…”
Section: Ifn Response and Progression In Cervical Neoplasiamentioning
confidence: 99%
“…Cells containing integrated high-risk HPV acquire a strong growth advantage over cells harbouring episomal high-risk HPV and undergo clonal expansion. These cells also show increased genomic instability [30,31] and therefore have a greater probability of acquiring the secondary genomic abnormalities that may drive malignant progression [32].…”
Section: Ifn Response and Progression In Cervical Neoplasiamentioning
confidence: 99%
“…More likely, these tumors arise from an initial tetraploidization event that is followed by frequent chromosome loss (Shackney et al, 1989). Indeed, tetraploid nuclei and supernumerary centrosomes have been noted in the early stages of some solid tumors (Reid et al, 1996; Kirkland et al, 1967). Importantly, tetraploidization after chemically-induced cytokinesis failure has been shown to promote tumorigenesis in p53-deficient mouse mammary epithelial cells (Fujiwara et al, 2005).…”
Section: Introductionmentioning
confidence: 99%
“…Genomic instability, producing specific genomic aberrations, is also associated with the development and progression of cervical carcinomas (13)(14)(15)(16). The temporal relationship between integration of HR-HPV and acquisition of a genetically unstable environment has not previously been demonstrated.…”
Section: Introductionmentioning
confidence: 99%