Comparative study of impact of hemodialysis and renal transplantation on cognitive functions in ESRD patients

Anwar, Waleed; Ezzat, Haitham; Mohab, Amr

doi:10.1016/j.nefro.2015.07.004

Cited by 16 publications

(23 citation statements)

References 12 publications

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“…In this investigation, hematocrit was associated with working memory (Letters and numbers), in line with previous findings [42]. Hemoglobin, which has previously been related to neuropsychological performance in ESRD-HD [3, 8], was associated with figural fluency (RFFT total design) in our study. No association was observed between Kt/v value and performance.…”

Section: Discussionsupporting

confidence: 92%

“…Regarding verbal fluency, Harciarek et al [24] found a reduced rate of word production of in phonological fluency tasks, while Post et al [25], also using the COWAT, reported worse performance in phonological and semantic verbal fluency. Regarding working memory, Anwar et al [8] and Costa et al [13] observed lower performance by ESRD-HD patients relative to HCs. Previous studies [3, 25] also found impaired inhibitory control in ESRD-HD patients.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies [3, 25] also found impaired inhibitory control in ESRD-HD patients. With respect to cognitive flexibility, Anwar et al [8] and Post et al [25] noted impairment in ESRD-HD patients on the Trail Making Test B. Concerning reasoning, Pereira et al [26] reported significant impairments in non-verbal fluency reasoning by ESRD-HD patients, but they did not include a control group (results were compared with normative data); in addition, their assessments were conducted during HD sessions, and thus may have been affected by the associated distractions/interferences.…”

Section: Discussionmentioning

confidence: 99%

“…EFs can be subdivided into several domains: updating (e.g., fluency, working memory, and reasoning), inhibitory control, cognitive flexibility, planning, and decision-making [7]. Studies of EFs in ESRD-HD have focused on specific domains such as fluency, inhibitory control, or planning [8, 4]; information is lacking on other key domains, including verbal reasoning and decision-making. Methodological shortcomings of previous studies include a limited battery of tests with which to evaluate EF-related domains [4], small sample sizes and insufficient consideration of relevant sociodemographic variables (e.g., age and years of education) [9].…”

Section: Introductionmentioning

confidence: 99%

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Executive function in end-stage renal disease: Acute effects of hemodialysis and associations with clinical factors

et al. 2018

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ObjectiveThere is evidence of cognitive impairment in patients with end-stage renal disease in hemodialysis (ESRD-HD). However, few studies have exhaustively analyzed executive functions (EFs) in this population, especially considering the influence of a wide range of clinical variables. This study analyzes performance in different EF components in ESRD-HD patients compared to a group of healthy controls (HCs), in addition to the acute effects of HD and the associations of cognitive performance with clinical variables.MethodEFs were evaluated pre- and post-HD in 43 ESRD-HD patients and 42 HCs, using a battery of tests designed to assess EF domains. Age, schooling, mood and blood pressure were statistically controlled. Associations between performance and clinical factors were computed by correlations and hierarchical multiple regression analyses.ResultsThe performance of the ESRD-HD patients was significantly lower than that of HCs in all the EF domains except for planning. Group differences were marginally significant for reasoning. HD produced no acute changes in global performance, with improvements see only in inhibition and working memory. EF scores were positively associated with total number of months previously transplanted, body mass index (BMI), dry weight, and levels of hemoglobin, albumin, ferritin, calcium, phosphorus, sodium, urea, and creatinine.ConclusionsGlobal EF functioning was lower in ESRD-HD patients than in HCs. No major acute HD-related EF changes were detected. These findings underline the importance of an adequate nutritional status for maintaining executive functioning in ESRD-HD patients.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Executive function in end-stage renal disease: Acute effects of hemodialysis and associations with clinical factors

et al. 2018

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“…Therefore, considering partly double prevalence of the two treatments and the side effects followed by each of them, several studies have been conducted on comparing two treatments in all of which the effect of treatments on the life quality has been studied to compare these treatments (7)(8)(9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Comparative Examination of the Life Quality in Hemodialysis Patients and Kidney Transplant Recipients in the Educational-Medical Centers of Ahvaz

Hovyzian

Fayazi

Sharhani

et al. 2017

Jundishapur J Chronic Dis Care

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Background: Kidney chronic failure and its replaced remedies make the patient exposed to a wide range of physical, mental, economic, and social problems and as the life quality is affected by them, the life quality would be changed. Therefore, evaluation of the life quality by specific evaluation tools and based on demographic information help the patients' problems to be dealt with principally. In this study, we examine the life quality of hemodialysis patients and kidney transplant recipients in Ahvaz. Methods: This study is a cross sectional study to compare the life quality of patients who had kidney transplantation or underwent hemodialysis treatment. Sampling was conducted based on purposeful method and the life quality of 70 patients and 70 kidney transplant recipients referring to medical center and the people who had the criterion for entering the study were examined by a questionnaire of kidney diseases' life quality (KDQOL-SF36); then, after collecting data, they were compared by applying statistical tests including T-test and Chi-square test. Results: The mean total scores of the life quality did not show a statistically significant difference in two groups (P = 0.344), but the kidney transplantation group with a significant mean difference obtained better scores in the dimensions of general health (P = 0.002), physical health (P = 0.000), sleep (P = 0.028), limitation in playing a role (P = 0.000), and physical limitation (0.002) in comparison with hemodialysis group. The two groups did not show any significant difference in dimensions of disorder in social natural function and social relations, physical pain, limitation because of pain, vivacity, coping with disease, inner emotion related to disease, self-knowledge, emotional issues, and sexual activities. Conclusions: Although kidney transplantation could increase the patients' life quality in some dimensions, in the kidney transplantation group the people still encounter their previous problems and are in need of receiving more care to keep their transplant kidney. Based on results, therefore, educational -medical centers must predict and implement necessary arrangements to increase the life quality in both groups.

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Comparison of the prevalence and associated factors of cognitive frailty between elderly and middle-young patients receiving maintenance hemodialysis

Chen

Zhang

et al. 2022

Int Urol Nephrol

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Purpose This study aimed at comparing the prevalence of cognitive frailty and explore the differences in the influencing factors between elderly and middle-young patients receiving maintenance hemodialysis (MHD). Methods In this cross-sectional study, the frailty phenotype, mini-mental state examination, and clinical dementia rating were used to assess the current status of cognitive frailty in 852 patients receiving MHD from four hospitals in Lianyungang City and Xuzhou City, Jiangsu Province, China; the influencing factors were then analyzed for statistical significance. Results Of the total 852 patients receiving MHD, 340 were classified into an elderly group (≥ 60 years) and 512 into a middle-young group (< 60 years). The prevalence of cognitive frailty was 35.9% and 8.8%, respectively. The results of multivariate logistic regression analysis showed that the independent factors of cognitive frailty were age (P < 0.001), education level (P = 0.010), nutritional status (P = 0.001), serum albumin level (P = 0.010), calf circumference (P = 0.024), and social support level (P < 0.001) in the elderly group and comorbidity status (P = 0.037), education level (P < 0.001), nutritional status (P = 0.008), serum creatinine level (P = 0.001), waist circumference (P < 0.001), and depression (P = 0.006) in the middle-young group. Conclusion The prevalence of cognitive frailty was significantly higher in the elderly group than in the middle-young group, and the influencing factors differed between the two populations.

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Comparative study of impact of hemodialysis and renal transplantation on cognitive functions in ESRD patients

Abstract: Renal transplantation as a modality of treatment, in ESRD patients, is superior to hemodialysis in terms of cognitive performance improvement.

Cited by 16 publications

References 12 publications

Executive function in end-stage renal disease: Acute effects of hemodialysis and associations with clinical factors

Executive function in end-stage renal disease: Acute effects of hemodialysis and associations with clinical factors

Comparative Examination of the Life Quality in Hemodialysis Patients and Kidney Transplant Recipients in the Educational-Medical Centers of Ahvaz

Comparison of the prevalence and associated factors of cognitive frailty between elderly and middle-young patients receiving maintenance hemodialysis

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