Comparative Study of Intrathecal Bupivacaine versus Bupivacaine with Fentanyl for Cesarean Section

Kamble, Neha P.

doi:10.5958/2394-4994.2016.00049.4

Cited by 3 publications

(4 citation statements)

References 5 publications

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“…These drugs have rapid onset, moderate duration of action, and low affinity to expand to the fourth vertebrae, and thus they are associated with a decreased risk of respiratory depression ( 21 ). Regardless of the wide use of opioids (6.25 - 50 mcg of fentanyl and 2.5 - 7.5 mcg of sufentanil) in combination with hyperbaric bupivacaine for Cesarean section, there is no consensus on the optimum dosage of fentanyl and sufentanil ( 3 , 5 - 7 , 22 , 23 ).…”

Section: Discussionmentioning

confidence: 99%

“…Injected neuroaxial drugs influence their surrounding tissues by the penetration. To date, many drugs have been used, but local anesthetics are the most important drugs ( 3 - 5 ). Bupivacaine at a concentration of 0.5%, became popular and a drug of choice for Cesarean section because of its long term block, sensory block separated from the motor block, relative lack of tachyphylaxis, and limited placental transfer ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

“…To date, many drugs have been used, but local anesthetics are the most important drugs ( 3 - 5 ). Bupivacaine at a concentration of 0.5%, became popular and a drug of choice for Cesarean section because of its long term block, sensory block separated from the motor block, relative lack of tachyphylaxis, and limited placental transfer ( 3 ). To increase the duration of anesthesia and improve the quality of analgesia during and after surgery, intrathecal opioids are used in combination with local anesthetics.…”

Section: Introductionmentioning

confidence: 99%

“…To increase the duration of anesthesia and improve the quality of analgesia during and after surgery, intrathecal opioids are used in combination with local anesthetics. It seems that opioid drugs in combination with local anesthetics have synergistic effects in spinal anesthesia ( 2 , 3 , 5 ). Hunt et al ( 4 ) described intrathecal fentanyl as a lipophilic opioid for the first time.…”

Section: Introductionmentioning

confidence: 99%

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Comparing the Effect of Adding Fentanyl, Sufentanil, and Placebo with Intrathecal Bupivacaine on Duration of Analgesia and Complications of Spinal Anesthesia in Patients Undergoing Cesarean Section

et al. 2017

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BackgroundSpinal anesthesia is the method of choice for most elective and emergency Cesarean sections. To increase the duration of anesthesia and improve the quality of analgesia during and after surgery, intrathecal opioids, as adjuvant drugs, are used in combination with local anesthetics.MethodsThis was a double-blind clinical trial performed on 99 patients. Women were divided into 3 groups of fentanyl, sufentanil, and placebo. For fentanyl group, 12.5 mg of bupivacaine and 25 micrograms of fentanyl; for sufentanil group, 12.5 mg of bupivacaine and 2.5 micrograms of sufentanil; and for placebo group, 12.5 mg of bupivacaine and a half mL of normal saline were injected in subarachnoid space. The sensory and motor block, hemodynamic status (mean blood pressure and heart rate), and probable complications were assessed.ResultsThere was no significant difference between the groups in demographic characteristics. Durations of analgesia were, respectively, 314 ± 42.95, 312.5 ± 34.44, and 116.1 ± 42.24 minutes in the fentanyl, sufentanil, and placebo groups (P = 0.0001). Duration of sensory and motor block was higher in fentanyl and sufentanil groups compared with the placebo group. The highest duration of sensory and motor block was noted in sufentanil group (P = 0.0001). No significant difference was found between the groups in the hemodynamic parameters (P > 0.05). The frequency of itching in the fentanyl group was higher than sufentanil and placebo groups (P = 0.003). Also, shivering was higher in the placebo group compared with other groups (P = 0.036).ConclusionsAccording to the results, adding 25 microgram fentanyl or 2.5 microgram sufentanil to intrathecal bupivacaine increased the duration of analgesia and provided hemodynamic stability with no major complication. As administering intrathecal fentanyl had a similar duration of analgesia like sufentanil with faster return of motor block and ambulation, it seems that it is a preferred additive for Cesarean section surgery.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Comparing the Effect of Adding Fentanyl, Sufentanil, and Placebo with Intrathecal Bupivacaine on Duration of Analgesia and Complications of Spinal Anesthesia in Patients Undergoing Cesarean Section

et al. 2017

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Effectiveness of prophylactic ondansetron in preventing spinal anesthesia induced hypotension and bradycardia in pregnant mother undergoing elective cesarean delivery: A double blinded randomized control trial, 2021

Salih

Befkadu

Assen

et al. 2021

International Journal of Surgery Open

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Background: Spinal anesthesia is the most common techniques of regional anesthesia for cesarean section. However, hypotension is the most common complication associated with nausea and vomiting, altered mental status and risk of aspiration. Bradycardia is also a common feature of profound circulatory collapse under neuraxial anesthesia. After verification that, serotonin can induce BJR reflex and can causes bradycardia or hypotension, researchers started to evaluate the effect of ondansetron to decrease BJR reflex in human being. Objectives: To assess the effect of prophylactic ondansetron for prevention of spinal induced hypotension and bradycardia in parturients undergoing cesarean delivery from June 1, 2020 to January 30, 2021. Method: ology: A double blinded randomized control trial conducted in Dilla university referral hospital by recruiting 70 patients with systematic random sampling technique. Patients were randomized into ondansetron group (n = 35) and control group (n = 35). Mann Whitney U test was used for continuous non-normally distributed data and independent sample t-test for normally distributed data. Mixed ANOVA was used to analysis the interaction of the within and between factors. Categorical variable between the groups were analyzed using fisher exact and chi square test. p -value<0.05 is considered statically significant. Result: There were no significant differences in the incidence of hypotension between ondansetron (20(57) and saline group (21(60%)). There were no significant difference in incidence of bradycardia among the two groups p > 0.05. Perioperative Phenylephrine consumption was 36.43 ± 45.91 mcg and 32.14 ± 46.79 mcg in ondansetron and saline group respectively with P = 0.700. The incidence of shivering was lower in ondansetron group (11%) than saline group (45%) with (p = 0.04) and the perioperative rescue shivering requirement was higher in saline group (p = 0.00). Conclusion: and Recommendations: Prophylaxis administration of intravenous Ondansetron at a dose of 10 mg before spinal anesthesia was not effective in reducing the incidence of hypotension and bradycardia in pregnant women undergoing cesarean section. Highlights

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Early versus delayed removal of indwelling catheters in patients after elective cesarean section: a prospective randomized trial

Başbuğ

Yüksel

Kaya

2018

The Journal of Maternal-Fetal & Neonatal Medicine

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Comparative Study of Intrathecal Bupivacaine versus Bupivacaine with Fentanyl for Cesarean Section

Cited by 3 publications

References 5 publications

Comparing the Effect of Adding Fentanyl, Sufentanil, and Placebo with Intrathecal Bupivacaine on Duration of Analgesia and Complications of Spinal Anesthesia in Patients Undergoing Cesarean Section

Comparing the Effect of Adding Fentanyl, Sufentanil, and Placebo with Intrathecal Bupivacaine on Duration of Analgesia and Complications of Spinal Anesthesia in Patients Undergoing Cesarean Section

Effectiveness of prophylactic ondansetron in preventing spinal anesthesia induced hypotension and bradycardia in pregnant mother undergoing elective cesarean delivery: A double blinded randomized control trial, 2021

Early versus delayed removal of indwelling catheters in patients after elective cesarean section: a prospective randomized trial

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