Comparative Study of Intravenous Iron Sucrose Versus Oral Iron Therapy in Iron Deficiency Anemia During Postpartum Period

Abstract

Background:-Nutritional anemia is one of major contributory factor in high maternal mortality and morbidity in third world countries. Iron deficiency is the principle cause for nutritional anemia. The aim of the study was to compare the efficacy of oral iron therapy with intravenous iron therapy in the treatment of iron deficiency anemia during postpartum period Material and Methods:-A clinical observational study was undertaken at tertiary care teaching hospital over a period of 15 months in one hundred recently delivered women. The baseline hemoglobin and serum ferritin levels were recorded prior to treatment. After completion of the treatment the women were followed up for changes in hemoglobin and serum ferritin levels on day 5, 14 and 40. Results :-.On day 5 of the intravenous iron group , there was statistically significant increase in serum ferritin level from 11.47 +1.655 µg/l to 41.44 +6.500 µg/l (p value <0.01), and the ferritin level remained elevated on day 14 and day 40. There was significant increase in mean Hb level from 7.76+0.7137 g/dl to 10.78+0.7679 g/dl on day 40 (p value < 0.01) in oral iron group. There was increase in mean Hb level from 7.47+0.7678 g/dl to 11.41+0.7908 g/dl on day 40 in injectable iron group, which was statistically significant. (p value < 0.01) Intravenous iron sucrose did not result in any serious adverse reactions. Conclusion:-Intravenous iron sucrose administration increases the hemoglobin level and serum ferritin levels more rapidly ,without any serious adverse effect in comparison with oral ferrous sulphate in women with iron deficiency anemia in the postnatal period .

A study of efficacy and safety of intravenous iron sucrose for the treatment of moderate anaemia in antenatal women in South India

“…Similar observations were reported in other studies like Prashant S. Kharde et al, Bayoumeu F et al and Khurshid Shabbir Raja et al without serious adverse effects. 15,17,18 This study is comparable with other two studies. In a study done by Agarwal Rohina S et al in 2010, showed baseline Hb 6.2g% and 5.95g%, Haematocrit 18.8 and 17.8%, MCV 71.28 and 70.1fl in IV and oral group respectively.…”

“…The average rise of haemoglobin was 3.54g/dl and 5.3g/dl in oral and IV group respectively. 15 In another study done by Momen. AI et al in 1996, has shown baseline Hb 7.58 and 7.66g% and MCV 68.6 and 70.8fl/cell in IV and oral group respectively.…”

Effect of treatment with single total-dose intravenous iron versus daily oral iron(III)-hydroxide polymaltose on moderate puerperal iron-deficiency anemia

“…They noted a faster increase in hematocrit value in the intravenous group from first to fourth postpartum week with 80% of the intravenous group and 40% of the oral group attaining their target hemoglobin of 12 g/dL. Similarly, Seid et al,35 Kharde et al36 and Van Wyck et al37 observed that the use of intravenous ferric carboxymaltose was associated with statistically significant rise in hemoglobin than in the oral group during treatment of postpartum anemia.…”

Effectiveness of intravenous iron sucrose over oral iron therapy for anaemia in pregnancy

“…14 Similarly, in the study conducted by Kharde et al, the average rise of haemoglobin was 3.54 g/dl and 5.3 g/dl in oral and IV group respectively with no major side effects in any of the cases. 15 With all these studies, it is clearly evident that there is an effective rise in hemoglobin level with Intravenous iron Sucrose. The mean base line haematocrit (PCV) is 26% and post treatment mean PCV improved to 34% which is highly reassuring.…”