Comparative study of isolated Guggulsterones as marker compounds from Guggulu, Commiphora mukul with Ayurvedic Gugglu containing formulations by HPTLC, an in-house quality control method

Duraipandi, Selvakumar; Selvakumar, Vijaya

doi:10.14805/jphchem.2014.art3

Cited by 6 publications

(1 citation statement)

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“…In the contemporary state, there has been a rapid rise in the use of alternative medicines especially herbal medicines for various disorders, Resins from the Commiphora species have been widely used for the management of arthritis, inflammation, cholesterol lowering activity, obesity, hemorrhoids and gastrointestinal disturbance 12,13 . Guggulsterone is one of the major bioactive compounds in commiphora species and also in MYG tablets, which www.nature.com/scientificreports/ is act as inhibitor on Farnesoid X receptor resulting in reduced lipid levels 14 .…”

Section: Discussionmentioning

confidence: 99%

CYP3A4 mediated pharmacokinetics drug interaction potential of Maha-Yogaraj Gugglu and E, Z guggulsterone

Sabarathinam

Chandra

Mahalingam

2021

Sci Rep

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Maha yogaraja guggulu (MYG) is a classical herbomineral polyherbal formulation being widely used since centuries. The aim of this study was to investigate the effect of MYG formulation and its major constituents E & Z guggulsterone on CYP3A4 mediated metabolism. In vitro inhibition of MYG and Guggulsterone isomers on CYP3A4 was evaluated by high throughput fluorometric assay. Eighteen Adult male Sprague–Dawley rats (200 ± 25 g body weight) were randomly divided into three groups. Group A, Group B and Group C were treated with placebo, MYG and Standard E & Z guggulsterone for 14 days respectively by oral route. On 15th day, midazolam (5 mg/kg) was administered orally to all rats in each group. Blood samples (0.3 mL) were collected from the retro orbital vein at 0.25, 0.5, 0.75, 1, 2, 4, 6, 12 and 24 h of each rat were collected. The findings from the in vitro & in vivo study proposed that the MYG tablets and its guggulsterone isomers have drug interaction potential when consumed along with conventional drugs which are CYP3A4 substrates. In vivo pharmacokinetic drug interaction study of midazolam pointed out that the MYG tablets and guggulsterone isomers showed an inhibitory activity towards CYP3A4 which may have leads to clinically significant interactions.

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Section: Discussionmentioning

confidence: 99%