Comparative study of lipoprotein lipase enzyme, ApoE and ApoC2, in pregnant women with and without preeclampsia

Abstract

Background: Preeclampsia (PE) is a multisystemic syndrome specific to pregnancy. Although PE is the most common cause of death from pregnancy-related problems, its underlying cause is still unknown. In PE, lipid metabolism is altered. When lipids are damaged, both the mother and the foetus may be at risk. Methods: Blood samples were taken from 45 normotensive and 45 preeclamptic pregnant women. These samples were analyzed for LPL, Apo E and C2. Results: Concentrations of LPL, Apo C2 and Apo E differ significantly between preeclamptic women and pregnant controls which were higher in preeclamptic than in pregnant controls. Conclusions: In preeclamptic women, the increase in LPL, ApoC2 and Apo E concentration may serve as a marker for preeclampsia complication that which leads to worse consequences and could be a relevant factor in the pathogenesis of preeclampsia.