Comparative Study of Liver Function Test Pattern in Obstructive Jaundice Due to Stones and Malignancy

K, Tiwari Ashutosh; Binay, Kumar; Mishra, Gaurav; Kar, Tanushree; Jiwesh, Kumar

doi:10.21088/nijs.0976.4747.10219.5

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ostruction jaundice is characterized by changes in the liver function that can be quantitatively assessed (Tiwari et al, 2019). Obstruction of the biliary ductus increases the pressure in the proximal ductus billiaris which normally ranges from 7-15 cm H2O, increasing to 18-30cm H2O due to the continuous bile produced by hepatocytes.…”

Section: Introductionmentioning

confidence: 99%

Lactococcus Lactis D4 Starter Fermented Milk’s Effect on Liver Function of Obstructive Jaundice Model

Anami

Rivai

Suchitra

et al. 2023

IJOMS

View full text Add to dashboard Cite

Obstructive jaundice can cause liver function damage which exacerbates patient morbidity and mortality. Fermented milk starter Lactococcus Lactis D4 derived from dadih is a probiotic that has the potential to improve liver function through the enterohepatic pathway. The research would like to determine the effect of Lactococcus Lactis D4 starter fermented milk on liver function of obstructive jaundice. This study was an experimental study with a post test only randomized control group design in 3 groups of Rattus Novergicus strain Wistar rats with obstructive jaundice model which got ligation of biliary ducts and given Lactococcus lactis D4 starter fermented milk for 7 days. Liver function was assessed by looking at the levels of total bilirubin, SGOT, SGPT, ALP, and GGT in each treatment group. Administration of Lactococcus Lactis D4 starter fermented milk caused a decrease in SGOT levels (LDB + BAL vs LDB: 51.12 ± 1.77 U/L vs 64.63 ± 0.10 U/L, p<0.05) and SGPT (LDB + LAB vs LDB: 60.60±0.85 U/L vs 67.77±2.60 U/L, p<0.05) which was significant. However, there was no significant effect on total bilirubin levels (LDB + BAL vs LDB: 3.21±0.11 mg/dl vs 3.18±0.10 mg/dl, p>0.05), ALP (LDB + LAB vs LDB: 108.20 ± 2.78 U/L vs 115.38 ± 5.08 U/L, p>0.05), and GGT (LDB + LAB vs LDB: 12.57 ± 0.45 U/L vs 12.78±0.31 U/L, p>0.05). Lactococus Lactis D4 starter fermented milk can improve liver function which is indicated by a decrease in SGOT and SGPT levels in experimental animals.

show abstract

Section: Introductionmentioning

confidence: 99%