Comparative Study of Lung Sealants in a Porcine Ex Vivo Model

Pedersen, Torben Brøchner; Honge, Jesper L.; Pilegaard, Hans K.; Hasenkam, J. Michael

doi:10.1016/j.athoracsur.2012.03.050

Cited by 43 publications

(43 citation statements)

References 20 publications

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“…The burst strength with a modification ratio of 10 mol% We also analyzed fracture patterns following burst strength measurements. In general, there are three kinds of fracture patterns: adhesion failure, cohesion failure and tissue tearing, with interfacial strength increasing in this order [30]. The fracture pattern after burst strength measurement of Org-ApGltn/4S-PEG-based sealant was found to be a cohesion failure, whereas 9.6Ste-ApGltn/4S-PEG-based sealant still remained on the surface of the blood vessel even after burst strength measurement.…”

Section: Discussionmentioning

confidence: 95%

“…To analyze the adhesion mechanism, a cross section of the blood vessel after the burst strength measurements was observed [30]. The test sample was fixed in a 10% formalin neutral buffer solution, stained with hematoxylin and eosin (H&E), and analyzed under an optical microscope (BX51, Olympus, Tokyo, Japan).…”

Section: Measurement Of the Burst Strength Of A Porcine Blood Vesselmentioning

confidence: 99%

See 1 more Smart Citation

Effect of alkyl chain length on the interfacial strength of surgical sealants composed of hydrophobically-modified Alaska-pollock-derived gelatins and poly(ethylene)glycol-based four-armed crosslinker

Mizuta

Ito

Taguchi

2016

Colloids and Surfaces B: Biointerfaces

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Section: Discussionmentioning

confidence: 95%

Section: Measurement Of the Burst Strength Of A Porcine Blood Vesselmentioning

confidence: 99%

Effect of alkyl chain length on the interfacial strength of surgical sealants composed of hydrophobically-modified Alaska-pollock-derived gelatins and poly(ethylene)glycol-based four-armed crosslinker

Mizuta

Ito

Taguchi

2016

Colloids and Surfaces B: Biointerfaces

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“…This demonstrates the suitability of Progel in lung resection surgery for closing air leaks [4]. In another study, the burst pressure values for different lung sealants were compared in an ex vivo study using a porcine model [103]. Bioglue (V-Tech, Roskilde, Denmark) attained the highest burst pressures compared to other tested sealants including Evicel (OMRIX biopharmaceuticals S.A, Belgium), Tisseel (Baxter, Denmark), TachoSil (Nycomed, Roskilde, Denmark), TissuePatchDural (Vingmed, Denmark), and Pleuraseal (Covidien, Denmark).…”

Section: Applications Of Elastic Surgical Sealantsmentioning

confidence: 99%

Elastic sealants for surgical applications

Annabi

Yue

Tamayol

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

200

176

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Sealants have emerged as promising candidates for replacing sutures and staples to prevent air and liquid leakages during and after the surgeries. Their physical properties and adhesion strength to seal the wound area without limiting the tissue movement and function are key factors in their successful implementation in clinical practice. In this contribution, the advances in the development of elastic sealants formed from synthetic and natural materials are critically reviewed and their shortcomings are pointed out. In addition, we highlight the applications in which elasticity of the sealant is critical and outline the limitations of the currently available sealants. This review will provide insights for the development of novel bioadhesives with advanced functionality for surgical applications.

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“…In many cases of uncontrollable bleeding and intractable air leakage, a number of adhesives have been utilized for hemostasis and air sealing. These include chemically crosslinkable gelatins [29], cyanoacrylate polymers [30,31], and fibrin glues [32,33]. Such adhesives are optimally non-irritating locally and non-toxic systematically and have appropriate flexibility and biodegradability.…”

Section: Photocrosslinked Chitosan Hydrogel (Pch)mentioning

confidence: 99%

“…Fibrin glue, which contains fibrinogen, thrombin, factor XIII, and protease inhibitors, exploits blood coagulation systems to seal tissues and is currently the most widely used surgical adhesive. Accordingly, its hemostatic and air sealing effects have been reported by many investigators [32,33]. However, industrial production of fibrin glue requires the use of human blood.…”

Section: Photocrosslinked Chitosan Hydrogel (Pch)mentioning

confidence: 99%

Application of hydrogels as submucosal fluid cushions for endoscopic mucosal resection and submucosal dissection

2015

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Numerous new techniques have recently been reported and described for the endoscopic mucosal resection (EMR) of large superficial lesions of the gastrointestinal tract, using various natural, synthetic, and semi-synthetic materials such as chitin/chitosan and their derivatives. Although saline-assisted EMR is an established minimally invasive therapy, en bloc resection and histopathological analyses are required to determine its curative potential. In addition, complete resection of lesions of >2 cm in diameter remains difficult, despite improved EMR techniques. The development of endoscopic submucosal dissection (ESD) has increased dissection rates for en bloc resection of large lesions, but perforation occurs more frequently during ESD than during EMR. Submucosal injections of those biomaterials which have high viscosity and hydrogelatinization ability as submucosal fluid cushions (SFC) may facilitate ESD as well as EMR for the treatment of superficial tumors of the alimentary tract. In this review, we describe the application of biomaterials such as chitosan derivatives, sodium hyaluronate, and 50% glucose as a SFC for ESD, focusing photocrosslinked chitosan hydrogels (PCH) which we have originally developed.

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Comparative Study of Lung Sealants in a Porcine Ex Vivo Model

Cited by 43 publications

References 20 publications

Effect of alkyl chain length on the interfacial strength of surgical sealants composed of hydrophobically-modified Alaska-pollock-derived gelatins and poly(ethylene)glycol-based four-armed crosslinker

Effect of alkyl chain length on the interfacial strength of surgical sealants composed of hydrophobically-modified Alaska-pollock-derived gelatins and poly(ethylene)glycol-based four-armed crosslinker

Elastic sealants for surgical applications

Application of hydrogels as submucosal fluid cushions for endoscopic mucosal resection and submucosal dissection

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