Comparative study of MR mTI-ASL and DSC-PWI in evaluating cerebral hemodynamics of patients with Moyamoya disease

Zhang, Jin-Ge; Xia, Chunchao; Liu, Yi; Weiqiang, Qian; Peng, Wanlin; Liu, Keling; Li, Lei; Zhao, Fei; Li, Zhenlin

doi:10.1097/md.0000000000012768

Cited by 10 publications

(9 citation statements)

References 25 publications

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“…Other studies have compared ASL to perfusion MRI. For example, Zhang et al 48 retrospectively explored the correlation between multi-inversion time ASL (mTI-ASL) and DSC-PWI in 24 patients with MMD. As in the study by Ha et al, 13 relative perfusion values were attained by dividing by the cerebellum value, for both ASL-and DSC-acquired images.…”

Section: Asl and Mrimentioning

confidence: 99%

“…Ultimately, their findings showed that mTI-ASL is a viable contrast-free alternative when assessing MMD preoperatively, with a strong correlation between relative CBF measured by ASL and that measured by DSC-PWI (r = 0.839, p < 0.001), using Pearson correlation analysis in all ROIs analyzed (total of 90 lateral MCA territories and basal ganglia). 48 Qiao et al 31 also compared mTI-ASL and DSC MRI in quantifying CBF before and after revascularization in 41 MMD patients. The results showed that CBF measured by ASL and relative CBF measured by DSC in 824 ROIs were significantly correlated (r = 0.316, p < 0.0001).…”

Section: Asl and Mrimentioning

confidence: 99%

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Clinical utility of arterial spin labeling imaging in disorders of the nervous system

Soldozy¹,

Galindo²,

Snyder³

et al. 2019

Neurosurgical Focus

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Neuroimaging is an indispensable tool in the workup and management of patients with neurological disorders. Arterial spin labeling (ASL) is an imaging modality that permits the examination of blood flow and perfusion without the need for contrast injection. Noninvasive in nature, ASL provides a feasible alternative to existing vascular imaging techniques, including angiography and perfusion imaging. While promising, ASL has yet to be fully incorporated into the diagnosis and management of neurological disorders. This article presents a review of the most recent literature on ASL, with a special focus on its use in moyamoya disease, brain neoplasms, seizures, and migraines and a commentary on recent advances in ASL that make the imaging technique more attractive as a clinically useful tool.

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Section: Asl and Mrimentioning

confidence: 99%

Section: Asl and Mrimentioning

confidence: 99%

Clinical utility of arterial spin labeling imaging in disorders of the nervous system

Soldozy¹,

Galindo²,

Snyder³

et al. 2019

Neurosurgical Focus

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“…Additionally, territory-specific perfusion measured by cerebral blood flow (CBF) imaging also plays a determine role in disease severity and whether to choose bypass surgery or not. Pseudocontinuous arterial spin labeling (pCASL) is a non-invasive MR perfusion imaging technique, which is a feasible way to access CBF changes in patients with MMD ( 11 , 12 ). pCASL with multiple postlabeling delay (PLD) could provide more accurate CBF measurements because of the severe intracranial arterial stenosis and occlusion.…”

Section: Introductionmentioning

confidence: 99%

Caveolin-1 Promoted Collateral Vessel Formation in Patients With Moyamoya Disease

Zhao

Zhang

et al. 2022

Front. Neurol.

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BackgroundCaveolin-1 (Cav-1) plays pivotal roles in the endothelial function and angiogenesis postischemia. Moyamoya disease (MMD) is characterized by progressive artery stenosis with unknown etiology. We aim to determine whether serum Cav-1 levels of patients with MMD were associated with collateral vessel formation after bypass surgery.MethodsWe studied serum Cav-1 levels of 130 patients with MMD (16 with RNF213 p.R4810K mutation and 114 without RNF213 p.R4810K mutation), 15 patients with acute stroke, and 33 healthy controls. Cerebral perfusion and collateral circulation were evaluated preoperation and at 6 months after operation using pseudocontinuous arterial spin labeling MRI (pCASL-MRI) and digital subtraction angiography (DSA), respectively. Endothelial expression of Cav-1 was verified in the superficial temporal artery (STA) wall of patients with MMD by immunofluorescence double staining. We also investigated whether overexpression of Cav-1 affects cell migration and tube formation using human microvascular endothelial cells (HMECs).ResultsThe serum Cav-1 level of patients with MMD intermediated between the stroke group and healthy controls and it was enhanced after the bypass surgery (681.87 ± 311.63 vs. 832.91 ± 464.41 pg/ml, p = 0.049). By 6 months after bypass surgery, patients with MMD with better collateral compensation manifested higher postoperative/preoperative Cav-1 ratio (rCav-1) than bad compensation patients. Consistently, cerebral blood flow (CBF) determined by pCASL-MRI (nCBFMCA ratio) was positively in line with rCav-1 ratio (r = 0.8615, p < 0.0001). Cav-1 was expressed in the endothelial cells of the STA vessels of patients with MMD. Overexpression of Cav-1 by plasmid transfection in HMECs promoted tube formation and cell migration.ConclusionThis study indicated that Cav-1 may be a potential driver to promote angiogenesis and collateral formation after bypass surgery in patients with MMD, providing a better understanding of MMD pathophysiology and potential non-surgical targets of MMD.

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“…Digital subtraction angiography (DSA) is the gold standard for diagnosis, but Magnetic Resonance Angiography (MRA) is also helpful [40,41]. More specific methods but not currently used because of the costs and equipment involved are xenon-enhanced CT, DSC, MRI, H 2 [ [15]O]-PET and [42]I aromatic amines SPECT [43][44][45][46][47][48]. These diagnostic techniques are used for preoperative evaluation to decide the best surgical approach.…”

Section: Introductionmentioning

confidence: 99%

Surgical Treatment of Moyamoya Disease

Vanaclocha¹,

Saiz-Sapena²,

Vanaclocha³

2021

Moyamoya Disease - A Disease to Count on in Your Daily Practice

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Moyamoya disease is a rare cerebrovascular disease most prevalent in East Asian Countries. Thanks to the new diagnostic capabilities, the number of cases discovered has been rising steadily in the latest years, including many asymptomatic patients. But asymptomatic from the clinical point of view does not necessarily mean that there are no subjacent problems and that there will be no disease progression. Indeed, many patients harbour cognitive decline long before they start with clinical or even radiological manifestations. The only effective treatment is surgical revascularization, with all its possibilities: direct, indirect, and combined. While direct techniques are more useful in adult moyamoya patients, children seem to benefit most from indirect techniques. Additionally, indirect or combined procedures can be used as salvage procedures in case of unsatisfactory outcomes. Thus, many surgeons posit that surgical treatment should be considered in moyamoya patients, even if asymptomatic, particularly in the paediatric age group.

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Comparative study of MR mTI-ASL and DSC-PWI in evaluating cerebral hemodynamics of patients with Moyamoya disease

Cited by 10 publications

References 25 publications

Clinical utility of arterial spin labeling imaging in disorders of the nervous system

Clinical utility of arterial spin labeling imaging in disorders of the nervous system

Caveolin-1 Promoted Collateral Vessel Formation in Patients With Moyamoya Disease

Surgical Treatment of Moyamoya Disease

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