Comparative study of ovarian clear cell carcinoma with and without endometriosis in People's Republic of China

Ye, Shuang; Yang, Jiaxin; You, Yan; Cao, Dongyan; Bai, Huimin; Lang, Jinghe; Chen, Jie; Shen, Keng

doi:10.1016/j.fertnstert.2014.08.008

Cited by 43 publications

(43 citation statements)

References 31 publications

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“…10 In that study, OCCC arising from endometriosis was associated with younger age, early-stage disease, and a lower incidence of ascites compared with OCCC associated with endometriosis. 10 As shown in Table 4, 3 studies have suggested an improvement in survival in OCCC with endometriosis, 9,10,12 although this was not observed in 3 other studies. 11,13,14 However, the latter 3 studies included only a small number of patients.…”

Section: Discussionmentioning

confidence: 95%

Significance of Ovarian Endometriosis on the Prognosis of Ovarian Clear Cell Carcinoma

Park

Kim

Suh

et al. 2018

International Journal of Gynecological Cancer

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Ovarian clear cell carcinoma with endometriosis was found more frequently in younger women and had a higher incidence of early-stage disease and a lower incidence of lymph node metastasis compared with OCCC without endometriosis. Ovarian endometriosis was associated with improved prognostic factors and a better DFS and OS even in stage I disease. Ovarian endometriosis was an independent prognostic factor for OCCC.

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Section: Discussionmentioning

confidence: 95%

Significance of Ovarian Endometriosis on the Prognosis of Ovarian Clear Cell Carcinoma

Park

Kim

Suh

et al. 2018

International Journal of Gynecological Cancer

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“…All other CCC patients with concomitant endometriosis were excluded. The histologic inclusion criteria of CCC were unclear in the studies by Komiyama et al, 14 Orezzoli et al, 10 and Ye et al 12 However, these studies defined endometriosis as pelvic concomitant endometriosis using the same criteria as we have used in the present study. To be able to compare our data with previous observations, we have decided to include primary CCC cases only.…”

Section: Discussionmentioning

confidence: 90%

“…The latter result is in line with the direction in most studies, 11,14 although not all reach a significant level. 10,12 Another explanation could be that endometriosis have burned out in the older age groups or that tumor spread may have veiled the endometriosis lesions in advanced CCC. Alternatively, the presence of endometriosis, which causes inflammation and an immunological imbalance in the surrounding microenvironment, may enhance malignant transformation leading to ovarian cancer at an earlier age.…”

Section: Discussionmentioning

confidence: 99%

Demographic, Clinical, and Prognostic Factors of Ovarian Clear Cell Adenocarcinomas According to Endometriosis Status

Schnack¹,

Høgdall

Thomsen³

et al. 2017

International Journal of Gynecological Cancer

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Age at CCC diagnosis and parity as well as histology differ between CCC patients with and without concomitant endometriosis. Furthermore, CCC patients with concomitant ovarian endometriosis have a poorer prognosis compared with endometriosis-negative CCC patients. These differences warrant further research to determine whether CCCs with and without concomitant endometriosis develop through distinct pathogenic pathways.

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“…Nevertheless, the complication with endometriosis was not a predictive factor of prognosis including PFS and OS. Until now, several studies had evaluated clinical significance of the correlation with endometriosis in prognoses of CCC, however, the conclusions have not been determined (7,11,14,16). According to recent meta-analysis conducted by Kim et al, the complication with endometriosis was not related with prognosis in all subtypes of ovarian cancers (7).…”

Section: Discussionmentioning

confidence: 99%

“…Recently, it has been pointed out that post-progression survival (PPS), defined as duration from the date of recurrence to the date of death, was relatively longer in ovarian cancers (16). Herein, we investigated the relationship with complication with endometriosis, and clinicopathological factors in CCC, including evaluation of PPS.…”

Section: Introductionmentioning

confidence: 98%

Role of endometriosis as a prognostic factor for post‑progression survival in ovarian clear cell carcinoma

et al. 2017

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Abstract.The clinical significance of coexistence of endometriosis (EM) in ovarian clear cell carcinoma (CCC) has not yet been determined. The aim of the present study was to analyze the correlation of endometriosis with clinicopathological factors in CCC. The cases with CCC that received primary debulking surgery at the present hospital between 1990 and 2013 were identified. Retrospective analysis was conducted to evaluate the association between complications with EM and clinicopathological features in CCC. Of the 105 cases enrolled in the study, 45 cases were complicated with EM, and 60 cases did not have EM (non-EM). The patients with EM were diagnosed at a younger age (P=0.03), and at earlier stages (P<0.01) compared with non-EM cases. Although there was no significant difference of progression-free survival (P= 0.36), complications with EM were identified as an independent prognostic factor for overall survival (OS; P<0.01) by multivariate analysis. A total of 48 patients (45.7%) developed recurrence: 18 patients in EM-group and 30 patients in non-EM group. There were no significant differences of clinicopathological factors in the treatment at recurrence between both groups. Recurrent cases in EM had significantly worse post-progression survival (PPS) compared with recurrent non-EM group (P<0.01). Multivariate analysis for PPS demonstrated that complications with EM (P<0.01) were identified as a worse prognostic factor. In CCC, the complication with EM was identified as a significant worse prognostic factor for PPS in recurrent cases. Additionally, EM was significantly associated with OS in all cases with CCC. Novel treatment strategies are therefore necessary for recurrent CCC, particularly for cases exhibiting EM.

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Comparative study of ovarian clear cell carcinoma with and without endometriosis in People's Republic of China

Cited by 43 publications

References 31 publications

Significance of Ovarian Endometriosis on the Prognosis of Ovarian Clear Cell Carcinoma

Significance of Ovarian Endometriosis on the Prognosis of Ovarian Clear Cell Carcinoma

Demographic, Clinical, and Prognostic Factors of Ovarian Clear Cell Adenocarcinomas According to Endometriosis Status

Role of endometriosis as a prognostic factor for post‑progression survival in ovarian clear cell carcinoma

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