Comparative study of pharmacokinetics and enzymatic resistance of the neuroprotective mean GZK-111 and noopept in rats

Abstract

The article presents the results of studying the pharmacokinetics and enzymatic stability of a new pharmacologically active compound GZK-111– N-phenylacetyl-glycyl-L-proline ethyl ether in comparison with noopept – N-phenylacetyl-L-prolyl-glycine ethyl ether in rats. It has been shown that both compounds are intensively metabolized in the body of experimental animals, while one of the main active metabolites of both compounds is cyclo-L-prolylglycine (CPG), which has similar neurotropic activity, but the intensity and speed of its formation during metabolic transformations is significantly more pronounced in GZK-111 compared to noopept. The significance of CPG in the realization of the main neurotropic effects of the studied compounds in the experiment in rats is shown.