Comparative study of photodynamic therapy with 5%, 10% and 20% aminolevulinic acid in the treatment of generalized recalcitrant facial verruca plana: a randomized clinical trial

Li, Q.; Jiao, Bin; Zhou, Fengjiao; Tan, Qing Rong; Ma, Yanyan; Zhai, Jiajia; Luan, Qi; Li, C.; Wang, Gang; Gao, Tianwen

doi:10.1111/jdv.12319

Cited by 25 publications

(21 citation statements)

References 16 publications

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“…[33] treated a total of 6146 lesions in 55 patients. ALA-PDT with 633 nm red light at concentrations of 5%, 10% and 20% were used and applied for 4 h. Three sessions were repeated at 2-week intervals.…”

Section: Clinical Applicationsmentioning

confidence: 99%

Photodynamic therapy in dermatology beyond non-melanoma cancer: An update

Wen

Hamblin

2017

Photodiagnosis and Photodynamic Therapy

163

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Photodynamic therapy (PDT) employs a photosensitizer (PS) and visible light in the presence of oxygen, leading to production of cytotoxic reactive oxygen species, which can damage the cellular organelles and cause cell death. In dermatology PDT has usually taken the form of topical application of a precursor in the heme biosynthesis pathway, called 5-aminolevulinic acid (or its methyl ester), so that an active PS, protoporphyrin IX accumulates in the skin. As PDT enhances dermal remodeling and resolves chronic inflamation, it has been used to treat cutaneous disorders include actinic keratoses, acne, viral warts, skin rejuvenation, psoriasis, localized scleroderma, some non-melanoma skin cancers and port-wine stains. Efforts are still needed to mitigate the side effects (principally pain) and improve the overall procedure.

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Section: Clinical Applicationsmentioning

confidence: 99%

Photodynamic therapy in dermatology beyond non-melanoma cancer: An update

Wen

Hamblin

2017

Photodiagnosis and Photodynamic Therapy

163

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“…A total of seven studies on PDT for wart treatment were found (Table ) with 109 patients treated. Six studies utilized ALA as a photosensitizer while one study used MAL.…”

Section: Resultsmentioning

confidence: 99%

“…A range of 5–20% ALA photosensitizer was used in several studies. A comparison of all three concentrations in one study suggests 10% ALA to be the optimal concentration for both efficacy and side‐effect profile . Those unable to tolerate ALA may use MAL, as it was seen to offer a similarly favourable outcome and side‐effect profile in one case report .…”

Section: Discussionmentioning

confidence: 99%

“…Li et al 30 treated a total of 6146 lesions in 55 patients. ALA-PDT at concentrations of 5%, 10% and 20% were used and applied for 4 h. Three sessions were done at 2-week intervals for a total dose of 339 J/cm 2 .…”

Section: Photodynamic Therapymentioning

confidence: 99%

“…[25][26][27][28][29][30][31] with 109 patients treated. Six studies utilized ALA as a photosensitizer while one study used MAL.…”

mentioning

confidence: 99%

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Laser and light therapy for facial warts: a systematic review

Maranda

Lim

Nguyen³

et al. 2016

Acad Dermatol Venereol

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Facial verruca plana, or flat warts, are benign skin papillomas caused by human papillomavirus infections. A large portion of cases are refractory to treatment and can cause psychosocial distress in patients. Laser and light modalities offer an alternative therapeutic approach that has not been extensively explored. We systematically reviewed PubMed for studies describing treatment of facial verruca plana using lasers, photodynamic therapy and infrared coagulation. Final inclusion and review of eighteen studies suggests laser and light therapies to have considerable potential in the treatment of this recalcitrant condition. In particular, yttrium aluminium garnet lasers, infrared coagulation and photodynamic therapies have been reported to demonstrate efficacy. Further studies with larger power are required to determine which method should be established as the alternative treatment of choice for recalcitrant facial verrucae.

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Principles of Photodynamic Therapy

Ibbotson,

McKenna

2024

Rook's Textbook of Dermatology

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Topical photodynamic therapy (PDT) is widely used as an effective and well‐tolerated treatment for field change actinic keratosis, Bowen disease and superficial basal cell carcinoma. There is a strong evidence base to support its use and guidelines, which summarise the evidence and clinical utility of this therapy. There are also standards available for guidance with respect to establishing PDT services in dermatology and emphasis is placed on the availability of PDT for practitioners affiliated with a skin cancer multi‐disciplinary team. Developments in photosensitisers and light delivery, such as through the increasing application of daylight PDT, have greatly improved the tolerance, acceptability and uptake of PDT, such that this should be widely available through dermatology services. Further refinements in photosensitiser and light delivery will be expected to continue to improve PDT outcomes and the uptake of this invaluable therapeutic approach.

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Comparative study of photodynamic therapy with 5%, 10% and 20% aminolevulinic acid in the treatment of generalized recalcitrant facial verruca plana: a randomized clinical trial

Abstract: This randomised clinical trial suggests that PDT with ALA of 10% concentration offers better efficacy and safety than 5% or 20% concentration for generalised recalcitrant facial verruca plana.

Cited by 25 publications

References 16 publications

Photodynamic therapy in dermatology beyond non-melanoma cancer: An update

Photodynamic therapy in dermatology beyond non-melanoma cancer: An update

Laser and light therapy for facial warts: a systematic review

Principles of Photodynamic Therapy

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