Comparative study of propofol versus midazolam in the sedation of critically ill patients

Chamorro, C.; Fj, de Latorre; Montero, Alejandro Fernández; Ja, Sánchez-Izquierdo; Jareño, Antonio; Ja, Moreno; Gonzalez, Edgar R.; Barrios, Maite; Jl, Carpintero; Martín-Santos, F; Otero, B; Ginestal, R

doi:10.1097/00003246-199606000-00010

Cited by 165 publications

(64 citation statements)

References 27 publications

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“…Induction midazolam dose of 0.07 mg/kg is based on experiences published previously by other authors [6,7]. Induction dose was administered intravenously while maintenance doses were administered subcutaneously.…”

Section: Methodsmentioning

confidence: 99%

Efficacy and safety of deep, continuous palliative sedation at home: a retrospective, single-institution study

Porzio

Aielli²,

Verna³

et al. 2009

Support Care Cancer

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Section: Methodsmentioning

confidence: 99%

Efficacy and safety of deep, continuous palliative sedation at home: a retrospective, single-institution study

Porzio

Aielli²,

Verna³

et al. 2009

Support Care Cancer

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“…Most trials comparing agents in long-term sedation (Ͼ3 days) compared propofol with midazolam. The use of propofol consistently resulted in more rapid awakening in these trials (5). This has been found to be especially useful in monitoring patients requiring frequent awakenings for neurologic assessment (13,14).…”

Section: Rationalementioning

confidence: 89%

“…Short-term sedation (Ͻ24 hrs) has been studied most often, comparing the sedative effects and properties of propofol vs. midazolam. In most of these studies, both these agents produce similar levels of sedation, although awakening times in patients sedated with midazolam were longer (8,5). Studies examining intermediate duration of sedation (1-3 days) have compared a variety of sedative agents.…”

Section: Rationalementioning

confidence: 99%

Sedation, analgesia, and neuromuscular blockade in sepsis: An evidence-based review

Vender¹,

Szokol²,

Murphy³

et al. 2004

Critical Care Medicine

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There is no preferred sedative or analgesic agent for use in the critically ill septic patient during mechanical ventilation. Protocols should be utilized for administration of sedation with predefined sedation scale targets. Either intermittent bolus sedation or continuous infusion sedation to predetermined end points with daily interruption/lightening of continuous infusion sedation with awakening and re-titration, if necessary, are recommended. Neuromuscular blockade should be avoided if possible and, if used continuously, requires twitch monitoring.

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“…The propofol has rapid and reliable action, which can completely produce the anesthesia induction effect within a brain-arm cycle and rapidly achieve the depth of anesthesia [1] . These two drugs are adopted in this paper to implement anesthesia induction in the elderly patients, which have definite effects, and the two groups that utilize propofol have remarkably reduced anesthesia induction time that the group using midazolam.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Various Anesthesia Induction Methods for the Anesthesia in Elderly Patients in the Abdominal Surgery

et al. 2017

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Abstract. Objective: To investigate the anesthesia induction methods in the elderly in surgeries. Methods: 60 cases of elderly patients in the Abdominal Surgery with ASA grade 1 to 3 were selected and randomly divided into three groups; intravenous injection of 4ug/kg of fentanyl and 0.1mg/kg of vecuronium bromide was conducted at first, and then group A was injected with 0.2mg/kg of midazolam, group B with 1.5mg/kg of propofol, and group C with 0.1mg/kg of midazolam and 1.0mg/kg of propofol for anesthesia induction within 1 min, and then the tracheal intubation was conducted. The effective time of anesthesia induction and the circulatory changes, as well as changes of PRA and Ang II values before anesthesia (T0), after anesthesia induction (T1), immediately after intubation (T3), and 5 min after intubation (T3) were observed. Results: The effective time of anesthesia induction was shorter in group C than in group A (P<0.05), and that was similar between group C and group B (P>0.05); compared with T0, the PRA and Ang II values in the three groups showed a decreasing trend at T1, T2 and T3, with the decrease being distinct at T1 (P<0.05); at T2, the PRA and Ang II values were significantly increased in group A (P<0.05), which were remarkably higher than those in group B and group C at the same period (P<0.05). The mean arterial pressure (MAP) and heart rate (HR) at T2 were notably increased in group A (P<0.05), while those were outstandingly reduced at T1 in group B (P<0.05), and group C had mild circulatory changes (P>0.05). The saturation of pulse oximetry (SPO2) was maintained between 97% and 100%. Conclusion: The combined use of midazolam and propofol is the ideal method for anesthesia induction in the elderly.

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Comparative study of propofol versus midazolam in the sedation of critically ill patients

Abstract: In this population of critically ill patients, propofol is an effective and safe alternative for sedation, with some advantages, such as short duration of action and high effectiveness over the conventional regimen with benzodiazepines and opiates.

Cited by 165 publications

References 27 publications

Efficacy and safety of deep, continuous palliative sedation at home: a retrospective, single-institution study

Efficacy and safety of deep, continuous palliative sedation at home: a retrospective, single-institution study

Sedation, analgesia, and neuromuscular blockade in sepsis: An evidence-based review

Comparison of Various Anesthesia Induction Methods for the Anesthesia in Elderly Patients in the Abdominal Surgery

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