Comparative Study of Pyrantel Pamoate, Bephenium Hydroxynaphthoate, and Tetrachloroethylene in the Treatment of Necator Americanus Infections

Botero, David; Castaño, Adriana

doi:10.4269/ajtmh.1973.22.45

Cited by 11 publications

(4 citation statements)

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“…The treatment of symptomatic trichiuriasis can be achieved with this drug. (BUMBALO et al 1969) and on a 3-day regimen against hookworm (BOTERO and CASTANO 1973), but is ineffective against T. trichiura (CERVONI and OLIVER-GONZALES 1971). Since its analogue oxantel is effective against the latter, it was rational to try to cover a wider spectrum of activity with a combination of both drugs.…”

Section: Discussionmentioning

confidence: 99%

“…BUMBALO et al (1969) showed its efficacy on E. vermicularis in the United States. Its efficacy against Ascaris, T. trichiura, and hookworm has been shown by in Taiwan, by DESOWITZ et al (1970) in the Cook Islands, by KOBAYASHI (1970) in Japan, by in Iran, by BELL and NASSIF (1971) in Cairo, by CERVONI and OLIVER-GONZALEZ (1971) in Puerto Rico, by VILLAREJOS et al (1971) in Costa Rica, and by BOTERO and CASTANO (1973) in Colombia. The majority of these trials drew attention to encouraging results in the treatment of hookworm.…”

Section: Commentsmentioning

confidence: 99%

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Chemotherapy of Gastrointestinal Nematodiasis in Man

Janssens¹

1985

Chemotherapy of Gastrointestinal Helminths

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Section: Discussionmentioning

confidence: 99%

Section: Commentsmentioning

confidence: 99%

Chemotherapy of Gastrointestinal Nematodiasis in Man

Janssens¹

1985

Chemotherapy of Gastrointestinal Helminths

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“…However, this goal relies solely on the use of mebendazole or albendazole, and their increasingly intensive use raises the threat of the selection and spread of drug-resistant hookworm populations. Also approved for this indication, but little used in mass drug administration campaigns for hookworm control, are pyrantel pamoate and levamisole, albeit with more limited success (Botero and Castano, 1973;Krepel et al, 1993;Reynoldson et al, 1997;Keiser and Utzinger, 2008). Oxantel pamoate is effective against whipworm infections (Howes, 1972;Garcia, 1976;Barda et al, 2018), but lacks efficacy against hookworms (Keiser et al, 2013;Speich et al, 2014;Moser et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

A Functional Comparison of Homopentameric Nicotinic Acetylcholine Receptors (ACR-16) Receptors From Necator americanus and Ancylostoma ceylanicum

Kaji

Geary

Beech

2020

Front. Mol. Neurosci.

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Effective control of hookworm infections in humans and animals relies on using a small group of anthelmintics. Many of these drugs target cholinergic ligand-gated ion channels, yet the direct activity of anthelmintics has only been studied in a subset of these receptors, primarily in the non-parasitic nematode, Caenorhabditis elegans. Here we report the characterization of a homopentameric ionotropic acetylcholine receptor (AChR), ACR-16, from Necator americanus and Ancylostoma ceylanicum, the first known characterization of human hookworm ion channels. We used two-electrode voltage clamp electrophysiology in Xenopus laevis oocytes to determine the pharmacodynamics of cholinergics and anthelmintics on ACR-16 from both species of hookworm. The A. ceylanicum receptor (Ace-ACR-16) was more sensitive to acetylcholine (EC50 = 20.64 ± 0.32 μM) and nicotine (EC50 = 24.37 ± 2.89 μM) than the N. americanus receptor (Nam-ACR-16) (acetylcholine EC50 = 170.1 ± 19.23 μM; nicotine EC50 = 597.9 ± 59.12 μM), at which nicotine was a weak partial agonist (% maximal acetylcholine response = 30.4 ± 7.4%). Both receptors were inhibited by 500 μM levamisole (Ace-ACR-16 = 65.1 ± 14.3% inhibition, Nam-ACR-16 = 79.5 ± 7.7% inhibition), and responded to pyrantel, but only Ace-ACR-16 responded to oxantel. We used in silico homology modeling to investigate potential structural differences that account for the differences in agonist binding and identified a loop E isoleucine 130 of Nam-ACR-16 as possibly playing a role in oxantel insensitivity. These data indicate that key functional differences exist among ACR-16 receptors from closely related species and suggest mechanisms for differential drug sensitivity.

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“…lumbricoides (Yokogawa et al, 1970;Kobayashi et al, 1970;Desowitz et al, 1970;Bell and Nassif, 1971; Kojima et al, 1978), Ancylostoma duodenale (Yokogawa et al, 1970;Hori, 1971;Simwogerere, 1972;Nassif and Bell, 1972), and Ne. americanus (Yokogawa et al, 1970;Ishizaki et al, 1971; Kobayashi et al, 1971;Simwogerere, 1972;Sato et al, 1973;Bortero and Castaso, 1973). The effect of pyrantel pamoate on single or multiple infections with As.…”

Section: Introductionmentioning

confidence: 99%

A parasitic survey and mass-treatment using pyrantel pamoate on Nigerian school children.

Kaneko

Ng²,

Ishola

1984

Jap. J. Trop. Med. Hyg.

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The survey and mass-teratment of helminthic infections with pyrantel pamoate was carried out on 140 school children in Ile-Ife, Western State of Nigeria. It was marked that 129 children were positive for Ascaris lumbricoides (As. lumbricoides), Trichuris trichiura (Tr. trichiura) or Necator americanus (Ne. americanus). Of the parasitepositive children, 82 could be allocated for the treatment with pyrantel pamoate.They were divided on the basis of having single, double or triple infections of the following intestinal nematodes; As. lumbricoides, Tr. trichiura and Ne. americanus.The results demonstrate that pyrantel pamoate is effective in curing As. lumbricoides almost completely, but is less effective against Tr. trichiura and Ne. americanus.

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Comparative Study of Pyrantel Pamoate, Bephenium Hydroxynaphthoate, and Tetrachloroethylene in the Treatment of Necator Americanus Infections

Cited by 11 publications

References 0 publications

Chemotherapy of Gastrointestinal Nematodiasis in Man

Chemotherapy of Gastrointestinal Nematodiasis in Man

A Functional Comparison of Homopentameric Nicotinic Acetylcholine Receptors (ACR-16) Receptors From Necator americanus and Ancylostoma ceylanicum

A parasitic survey and mass-treatment using pyrantel pamoate on Nigerian school children.

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