Comparative study of radical scavenger and antioxidant properties of phenolic compounds from Vitis vinifera cell cultures using in vitro tests

Fauconneau, Bernard; Waffo-Téguo, Pierre; Huguet, François; Barrier, Laurence; Décendit, Alain; Mérillon, Jean‐Michel

doi:10.1016/s0024-3205(97)00883-7

Cited by 414 publications

(247 citation statements)

References 20 publications

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“…It has been reported that a low dose of resveratrol has cytoprotective activity, which is mostly attributed to its antioxidant properties. On the other hand, a high dose of resveratrol exhibits anticancer activity by interfering with different cellular events associated with the initiation, promotion and progression of multi-stage carcinogenesis (12,13). The present study found that resveratrol elicited a dose-dependent inhibition of glioma cell proliferation in the micromolar range.…”

Section: Discussionsupporting

confidence: 52%

Resveratrol-induced autophagy in human U373 glioma cells

Yamamoto¹,

Suzuki²,

Himeno³

2010

Oncology Letters

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Abstract. Autophagy is an intracellular protein transport process leading to the degradation of organelles and long-lived proteins in eukaryotes. The down-regulation of autophagy observed in cancer cells has been associated with tumor progression. This study investigated autophagy induced by resveratrol, a natural compound, in human glioma cells. Glioma cells were exposed to resveratrol, and the cell growth and autophagic level were evaluated. Resveratrol inhibited growth and induced cell death in U373 glioma cells. When treated with resveratrol, glioma cells stably expressing GFP fused to LC3, recruited more GFP-LC3-labeled autophagosomes, and the percentage of cells with GFP-LC3-labeled autophagosomes increased. Furthermore, in resveratroltreated glioma cells, pretreatment with P38 or ERK1/2 inhibitors reduced the autophagic level, suggesting that resveratrol-induced autophagy was positively regulated by P38 and the ERK1/2 pathway. The Akt/mTOR pathway was not involved in resveratrol-induced autophagy. Our results suggest that resveratrol has an anticancer effect on glioma cells by inducing autophagy.

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Section: Discussionsupporting

confidence: 52%

Resveratrol-induced autophagy in human U373 glioma cells

Yamamoto¹,

Suzuki²,

Himeno³

2010

Oncology Letters

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“…Oxidation of LDL cholesterol is strongly associated with risk of CVD (Holvoet, 2004). In rat liver microsomes, RS inhibited iron-induced as well as ultraviolet-irradiated lipid peroxidation and prevented LDL oxidation by copper (Fauconneau et al, 1997;Miura et al, 2000). RS could effectively prevent oxidative LDL modification by inhibiting lipoxygenase enzyme activity (Maccarrone et al, 1999;Kovanen and Pentikäinen, 2003).…”

Section: Inhibitory Effect Of Rs On Ros Production and Lipid Peroxidamentioning

confidence: 99%

“…RS has also been shown to offer protection against ischemic injuries (Wang et al, 2002a) and neurodegenerative diseases (Fremont, 2000;Hung et al, 2000;Sun et al, 2002). A number of studies exist regarding the beneficial effects of RS on cardiovascular disease (CVD) with the positive effects being attributed to its anti-oxidant (Fauconneau et al, 1997;Martinez and Moreno, 2000;Sato et al, 2000) and anti-coagulative properties (Bertelli et al, 1996b;Soleas et al, 1997). Various anti-atherogenic mechanisms have been proposed for RS in reducing the CVD risk including alteration in lipid metabolism.…”

Section: Introductionmentioning

confidence: 99%

Anti-atherogenic effects of resveratrol

Ramprasath

Jones

2010

Eur J Clin Nutr

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Resveratrol (RS), a polyphenol compound found in grapes and grape products, including wine, peanuts and berries, exists in cis-and trans-isomeric forms. RS is believed to decrease circulating low-density lipoprotein cholesterol levels and reduce cardiovascular disease (CVD) risk. However, it is possible that RS has other mechanisms to reduce the risk of CVD without altering lipid levels. The objective of this review is to critically examine results from recent research concerning potential effects of RS on CVD. RS exerts several health benefits including anti-atherogenic, anti-inflammatory and anti-cancer effects. RS may also prevent lipid oxidation, platelet aggregation, arterial vasodilation and modulates the levels of lipids and lipoproteins. As a potent, anti-oxidant RS reduces oxidative stress and regenerates a-tocopherol, which further strengthens the anti-oxidant defense mechanism. RS has been considered safe as no significant toxic effects have been identified, even when consumed at higher concentrations. This evidence identified RS as an effective anti-atherogenic agent, which could be used in the prevention and treatment of CVD.

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“…These include the N, N-dimethyl-p-phenylendiamine assay (DMPD assay) (Fogliano et al, 1999;Schlesier et al, 2002), the 1,1-diphenyl-2-picrylhydrazyl assay (DPPH assay) (Bondet et al, 1997;Fauconneau et al, 1997), the Trolox equivalent antioxidant capacity assay (TEAC assay) (Miller et al, 1996;Re et al, 1999), the total radical-trapping antioxidant parameter assay (TRAP assay) (Wayner et al, 1985;Ghiselli et al, 1995), and the ferric reducing/antioxidant power assay (FRAP assay) (Benzie & Strain, 1996. There are also methods that measure inhibition of lipid peroxidation, such as the peroxide value assay (POV assay) (Steger & Mühlebach, 1997) and the 2-thiobarbituric acid assay (TBA assay) (Coudray et al, 1995;Guillén-Sans & Guzmán-Chozas, 1998).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity of Chinese Medicinal Herbs

Chan

Kwok

et al. 2008

Pharmaceutical Biology

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Sequential extraction with petroleum ether, chloroformethyl acetate, methanol, and water was carried out on 40 commonly used Chinese medicinal herbs. The antioxidant power of different fraction extracts was measured with both the DPPH assay and the FRAP assay. Ascorbic acid and butylated hydroxytoluene were used as two reference antioxidants. The total phenolic content of the extracts was measured by Folin-Ciocalteu method. The fraction extracts showed different antioxidant activity in the two assays; however, there was a significant positive correlation between the DPPH assay and the FRAP assay. Methanol fraction extracts generally demonstrated stronger antioxidant power and higher total phenolic content than did the others. The results suggest that Radix Sanguisorbae, Cortex cinnamomi, Herba taxilli, Semen arecae, and L., Cinnamomum cassia Presl ., Taxillus sutchuenensis (Lecomte) Danser, Areca catechu Linn. and Scutellaria baicalensis Georgi contain relatively high values in antioxidant power and/or high total phenolic content. This study is the first comprehensive antioxidant activity evaluation among Chinese medicinal herbs. It demonstrates that most Chinese medicinal herbs are also useful in preventing various degenerative diseases.

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Comparative study of radical scavenger and antioxidant properties of phenolic compounds from Vitis vinifera cell cultures using in vitro tests

Cited by 414 publications

References 20 publications

Resveratrol-induced autophagy in human U373 glioma cells

Resveratrol-induced autophagy in human U373 glioma cells

Anti-atherogenic effects of resveratrol

Antioxidant Activity of Chinese Medicinal Herbs

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