Comparative study of redox characteristics and antioxidant activity of porphyrins with 2,6-dialkylphenol groups

The Application of Novel Electrochemical Approach to Antioxidant Activity Assay of Metal Porphyrins with Bulky 3,5-Diisobornyl-4-hydroxyphenyl Moieties

“…In general it can be concluded that the introduction of the metal ion in the macrocycle of porphyrins, has a significant influence on the antioxidant activity of porphyrins containing bulky alkyl substituents. It is noteworthy that, in accordance with the data [11], all of the complexes studied exhibit markedly higher activity than 2,6-diisobornyl-4-methylphenol and belong to a class of effective antioxidants. ) based on meso-tetrakis (3,5-diisobornyl-4-hydroxyphenyl)porphyrin were synthesized and their redox properties were studied.…”

“…Previously, it has been shown that tetra(3,5-di-tert-butyl-4-hydroxyphenyl)porphyrin, containing BHT moieties, and its analogue with the palmitoyl residues exhibit a high antioxidant activity in the model oxidation reaction of (Z)-9-octadecenoic acid, as well as in the lipids peroxidation processes in Wistar rat liver homogenates [9] [10]. The activity of tetra(3,5-diisobornyl-4-hydroxyphenyl)porphyrin 1 was studied by electrochemical methods and it was shown that this compound may be considered either as a promising antioxidant [11], or as a membrane protector [12]. The introduction of the metal in the porphyrin core can have a direct effect on the antioxidant properties due to the participation in redox processes, which is of interest in terms of search for novel antioxidants.…”

Electrochemical properties and antioxidant activity of tetraphenylporphyrin derivatives

“…Potential in CVs of the DPPH solution was swept from the working electrode poten tial in the solution (~0.45 V) first towards the more negative potentials and then towards positive poten tials. There are two one-electron reversible waves in the voltammogram of DPPH in the range of potentials from 0 to 1.2 V corresponding to reduction and oxida tion of the radical [22][23][24]. The molecular form of the DPPH radical exists in the range of positive potentials (~0.4 to ~0.7 V) vs. SCE.…”

Synthesis, Electrochemical Properties and Antioxidant Activity of Hydroxy Substituted Tetraphenylporphyrins

“…[5][6] Указанные факты делают эти соединения привлекательными с точки зрения использо-вания в качестве потенциальных антиоксидантов и пока-зывают перспективы практического применения. [7][8][9] Методы определения антиоксидантной активно-сти веществ можно разделить по способу регистрации активности потенциальных антиоксидантов на: фотоме-трические, [10][11][12][13][14][15] хемилюминесцентные, [16] волюмометри-ческие, [17] флуоресцентные, [18][19][20] электрохимические [21][22] и др. ; [23,24] по типу источника окисления и окисляемого соединения.…”