Comparative Study of Resting Metabolic Rate and Plasma Amino Acid Profile in Patients Who Underwent Laparoscopic Roux-en-Y Gastric Bypass and Laparoscopic Sleeve Gastrectomy: 6-Month Follow-up Study

Golzarand, Mahdieh; Toolabi, Karamollah; Hedayati, Mehdi; Azam, Kamal; Douraghi, Masoomeh; Djafarian, Kurosh

doi:10.1007/s11695-019-03969-3

Cited by 11 publications

(3 citation statements)

References 47 publications

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“…The main purpose of performing bariatric procedures at any age is long-term sustainable weight loss and recovery from obesity-related comorbidity. It is important to acknowledge that BS-induced weight loss, regardless of the procedure performed, is not different from other sorts of weight loss and leads to a sustained metabolic adaptation that favors weight regain [45, 46]. Data from multiple groups indicate that the early effect of these procedures in general (with some delicate differences between them) is highly positive and that the first 12–18 months post-op are characterized by a substantial excess weight loss.…”

Section: Long-term Implications Of Bariatric Procedures Performed In ...mentioning

confidence: 99%

Bariatric Surgery in Adolescents with Obesity: Long-Term Perspectives and Potential Alternatives

Halloun

Weiss

2021

Horm Res Paediatr

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Background: Severe obesity among adolescent shows a worrisome trend in regard of its increasing prevalence and poses a great challenge for treatment. Conservative measures have modest effects on weight loss, usually fail in achieving a sustainable weight loss and resolution of comorbidities. This has led to greater utilization of bariatric surgery (BS) that offers a fast reduction in body mass index (BMI) with little perioperative complications. Despite the increasing utilization of BS, data is still insufficient, regarding their long-term outcome in adolescents. We review short and long-term effects of bariatric surgery and their implications on bone health and nutritional deficiencies in adolescents. In addition, we discuss possible pharmaceutical alternatives. Summary: BS results in a substantial weight loss of roughly 37% in the first-year post-operation and is superior to conservative measures in resolution of metabolic comorbidities. BS significantly improves health-related quality of life. Longer follow up, shows weight regain in 50% of patients. Furthermore, reduced bone mass and nutritional deficiencies were reported in up to 90% of patients. Most recently, alternative to BS became more relevant with approval of GLP-1 analogues use in adolescents. GLP-1 analogues are potent enough to induce moderate clinically meaningful weight loss and improvement of metabolic component. Key Messages: We conclude that obese adolescents without major obesity related complications may benefit from pharmacological interventions with lifestyle modification. We advise considering BS as treatment approach in adolescents with severe obesity and major obesity related complications with proper pre-operative preparation and post operative follow up in excellence centers.

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Section: Long-term Implications Of Bariatric Procedures Performed In ...mentioning

confidence: 99%

Bariatric Surgery in Adolescents with Obesity: Long-Term Perspectives and Potential Alternatives

Halloun

Weiss

2021

Horm Res Paediatr

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“… 4 The circulating BCAA level has been reported to decrease with a decrease in the body weight after diet intervention or weight loss surgery. 5 , 6 …”

Section: Introductionmentioning

confidence: 99%

“…4 The circulating BCAA level has been reported to decrease with a decrease in the body weight after diet intervention or weight loss surgery. 5,6 To achieve weight-loss, several diet interventions have been developed and used. Among them, an intervention system integrating a mobile app, wireless body composition scale, and diet replacement product, called the Metawell program, was developed in China and has been proven to be effective in previous studies.…”

Section: Introductionmentioning

confidence: 99%

Baseline Serum BCAAs are Related to the Improvement in Insulin Resistance in Obese People After a Weight Loss Intervention

Zhang¹,

Wang²,

Wu³

et al. 2023

DMSO

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Background Branched chain amino acids (BCAAs) have been revealed to be closely related to insulin resistance and obesity. This study aimed to investigate if BCAA levels at baseline are related to an improvement in insulin resistance after implementing a weight loss program intervention. Methods Stored blood samples from participants in previous trials were used for BCAA evaluation. Linear regression was used to analyze the relationship between baseline amino acid levels and changes in the insulin resistance index (HOMA-IR) and blood glucose. Results A total of 48 participants were enrolled. After the intervention, the body weight (78.29± 12.68 vs 72.06 ± 13.30 kg, p=0.020), fasting glucose (4.76 ± 0.43 vs 4.48 ± 0.39 mmol/L, p=0.001), fasting insulin (18.41±13.58 vs 12.87±10.88, p=0.028), and HOMA-IR (4.01±3.39 vs 2.62± 2.18, p=0.018) were improved significantly. BCAA levels were related to the improvement in HOMA-IR (β=−0.006, p=0.039), and valine was found to be the most closely related to the improvement in HOMA-IR (β=−0.013, p=0.017). Conclusion The baseline BCAA is related to the improvement in insulin resistance among participants after a weight loss intervention.

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Comparison of Laparoscopic Roux-en-Y Gastric Bypass and Laparoscopic Sleeve Gastrectomy on Weight Loss, Weight Regain, and Remission of Comorbidities: A 5 Years of Follow-up Study

et al. 2019

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Comparative Study of Resting Metabolic Rate and Plasma Amino Acid Profile in Patients Who Underwent Laparoscopic Roux-en-Y Gastric Bypass and Laparoscopic Sleeve Gastrectomy: 6-Month Follow-up Study

Cited by 11 publications

References 47 publications

Bariatric Surgery in Adolescents with Obesity: Long-Term Perspectives and Potential Alternatives

Bariatric Surgery in Adolescents with Obesity: Long-Term Perspectives and Potential Alternatives

Baseline Serum BCAAs are Related to the Improvement in Insulin Resistance in Obese People After a Weight Loss Intervention

Comparison of Laparoscopic Roux-en-Y Gastric Bypass and Laparoscopic Sleeve Gastrectomy on Weight Loss, Weight Regain, and Remission of Comorbidities: A 5 Years of Follow-up Study

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