Comparative study of serum ferritin levels after oral supplementation with ferrous sulphate and carbonyl iron in mild iron deficiency anemia in pregnancy

Chandrika, Nishad Thamban; Vasudha, K.

doi:10.4314/ijbcs.v4i2.58125

Cited by 5 publications

(3 citation statements)

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“…Similar results were observed in the study conducted by N. Chandrika and KC Vasudha. [14] In our study about 90% of the patients in the Carbonyl iron group achieved the WHO target of 11 gm% as compared to the ferrous sulphate group where only 20% and the ferrous fumarate group where 35% of the patients were able to achieve the WHO target.…”

Section: Groupmentioning

confidence: 85%

Comparative Study of Iron Supplements in South Indian Antenatal Women With Iron Deficiency Anemia

Geetha¹,

Rageshwari²,

Parvathavarthini³

et al. 2014

jemds

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BACKGROUND:Iron deficiency anemia is the most common nutritional disorder in the world. It is a major public health problem particularly among pregnant women with adverse effects on the mother and the new born. Iron supplementation is universally recommended to correct or prevent iron deficiency. AIMS & OBJECTIVE: The present study was conducted to compare the efficacy and tolerability of three oral iron preparations in anemic pregnant women of more than 14 weeks of gestation. MATERIALS AND METHODS: Randomized Control trial, done at Tagore Medical College and Hospital, Chennai. 60 antenatal women were selected; they were divided into three groups, 20 in each group. They were treated with Carbonyl iron, ferrous sulphate and ferrous fumarate. Hemoglobin estimation was done at 0 day, 30 th and 60 th day. Adverse effects were monitored. RESULTS: Data analysis showed an increase in haemoglobin levels in all three groups after the 30 th day (p<0.05). Carbonyl iron showed highly significant increase (p<0.05) in the haemoglobin level as compared to the other two drugs at the end of the 60 th day. CONCLUSION: Carbonyl iron is superior in efficacy when compared to ferrous sulphate and ferrous fumarate and is better tolerated. So carbonyl iron is safe in pregnancy and can be given as a supplement to treat iron deficiency anemia during pregnancy. KEYWORDS: Antenatal women, carbonyl iron, iron deficiency anemia. INTRODUCTION:Anemia is a global public health problem. In pregnant women anemia is due to iron deficiency, which is the most common nutrient deficiency in the world. According to WHO data, prevalence of anemia in pregnant women is 14% in developed countries and 51% in developing countries. [1] In India the prevalence of anemia is 65-75% in pregnant women, this high prevalence is due to poor socioeconomic status, dietary habits, poor health status, multi parity and less birth spacing.20% of all maternal deaths are contributed to anemia. [2,3] Anemia is defined as a qualitative or quantitative deficiency of circulating haemoglobin, leading to decreased oxygen carrying capacity of the red blood cells to the tissues. [4] It is divided into three degrees, mild (10.9-9.0 gm %), moderate (8.9-7.0 gm %) and severe (<7.0 gm %). [5] During pregnancy, women go through a variety of physiological changes especially in the blood circulatory system. Average iron requirement is 4 mg/ day throughout pregnancy; this varies from 2.5 mg/day in early pregnancy to 6-8 mg/day from 32 weeks onwards. Iron deficiency anemia occurs because of the increased iron requirements that are needed to supply the expanding blood volume of the mother and the rapidly growing fetus and placenta.Iron absorption in food is less than 10%, this requires at least 40-60 mg of iron in the diet to achieve 4-6 mg of absorption and if the pre pregnancy iron stores are low then the amount of iron needed during the last half of the pregnancy cannot be met with diet alone. [6,7]

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Section: Groupmentioning

confidence: 85%

Comparative Study of Iron Supplements in South Indian Antenatal Women With Iron Deficiency Anemia

Geetha¹,

Rageshwari²,

Parvathavarthini³

et al. 2014

jemds

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“…Serum ferritin changes were significantly higher at weeks 3 to 5. Chandrika et al [24] analyzed mild iron deficiency anemia in pregnancy and concluded that change (mean difference) in Hb, serum ferritin, and serum iron in ferrous sulphate group significantly increased. Similar studies observed increases and decreases in iron parameters could be attributed to different patient groups, dose and therapy variations and follow-up timelines.…”

Section: Discussionmentioning

confidence: 99%

Comparing therapeutic effects of alternate day versus daily oral iron in women with iron deficiency anemia: A retrospective cohort study

et al. 2023

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In order to replenish iron stores and bring hemoglobin (Hb) levels back to normal, oral iron is the primary treatment option for women with iron deficiency anemia (IDA). This study investigated the efficacy and side effects of daily versus alternate-day, given single doses versus double doses oral iron supplementation for treating IDA. A retrospective cohort study was performed between 2021 and 2022, including 120 patients. Study group were divided into 4 age-sex-matched groups; Group I (n = 30) and Group II (n = 30) which were received ferrous sulphate tablets daily in single or double doses, respectively, containing 60 mg of elemental iron each. Groups III (n = 30) and IV (n = 30) were received a single and double dose on alternate days, respectively. The primary outcome was the mean difference in Hb from baseline at week 4. Gastrointestinal (GI) side effects were accepted as a secondary outcome. The daily single dose and alternate day double dose groups had median Hb changes of 2.3 (2.1) and 2.6 (1.8) g/dL. The differences in Hb between Groups I and II, I and III, and Groups IV and II, IV and III were significant (P < .001, P = .001, P < .001, and P < .001, respectively). There is no significant difference between groups regarding improving iron parameters such as serum iron, total iron binding capacity, transferrin saturation, and ferritin. The incidence of GI side effects were greater in double doses than in single doses of daily or alternate-day therapies (43.3% and 30% vs 10% and 3.3%). Daily or alternate-day double dose resulted in more side effects but less therapeutic efficacy in women with IDA. To find the best supplementation method, randomized controlled trials with a larger sample of participants, longer study lengths, and various iron doses may be helpful.

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“…So, limitations of conventional iron salts have resulted in emergence of newer oral iron preparations like Carbonyl iron, Iron polymaltose complex, Ferrous ascorbate, Sodium feredetate and Ferrous bisglycinate. 5 A mild deficiency should not affect baby while pregnancy. But if mild iron deficiency anemia goes untreated and becomes more severe during pregnancy is linked to an increased risk of a baby being born with a low birth weight.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Efficacy and Tolerability of Ferrous Sulfate and Carbonyl Iron in Iron Deficiency Anemia in Pregnant Woman

Ahmed¹,

Shahriar²,

Iqbal³

et al. 2022

Sir Salimullah Med. Coll. J.

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Introduction: Iron deficiency anemia in pregnancy is common and causes a huge burden globally. Bangladesh is known to have a high prevalence of iron deficiency anemia in pregnant women. Hence, it is important to evaluate the efficacy and tolerability of drugs in treatment of iron deficiency anemia in pregnancy. Objective: The purpose of present study was to compare the efficacy and tolerability of Ferrous Sulfate and Carbonyl Iron in Iron Deficiency Anemia in pregnant women. Methodology: An observational prospective study was conducted in obstetric and gynae out – patient department of Sir Salimullah Medical College and Mitford Hospital. Woman between 16 – 28 weeks of pregnancy with haemoglobin level 7 – 10 g/dl with microcytic hypochromic blood film were included in this study. Pregnant women in 1st and 3rd trimester of pregnancy were excluded from the study. Among the study population one group was given Tablet Ferrous Sulfate and another group was given Capsule Carbonyl Iron. Results: There was significant and comparable rise in HB in 4th, 8th and 12th week in the two group. (p<0.001). Carbonyl iron showed significantly more rise in Hb as compared to Ferrous Sulfate. Adverse effects were seen more in number and intensity with Ferrous Sulfate. Individual efficacy of both compounds was good but Carbonyl Iron was better tolerated. Conclusion: Carbonyl Iron is more effective and tolerable than Ferrous Sulfate in treatment of iron deficiency anemia in pregnancy. Sir Salimullah Med Coll J 2022; 30: 83-88

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Comparative study of serum ferritin levels after oral supplementation with ferrous sulphate and carbonyl iron in mild iron deficiency anemia in pregnancy

Cited by 5 publications

References 14 publications

Comparative Study of Iron Supplements in South Indian Antenatal Women With Iron Deficiency Anemia

Comparative Study of Iron Supplements in South Indian Antenatal Women With Iron Deficiency Anemia

Comparing therapeutic effects of alternate day versus daily oral iron in women with iron deficiency anemia: A retrospective cohort study

Comparison of Efficacy and Tolerability of Ferrous Sulfate and Carbonyl Iron in Iron Deficiency Anemia in Pregnant Woman

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