Comparative study of skin phototoxicity with three drugs by an in vivo mouse model

Matsumoto, N.; Akimoto, Akira; Kawashima, Hiroyuki; Kim, Soonih

doi:10.2131/jts.35.97

Cited by 20 publications

(14 citation statements)

References 5 publications

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“…ENO, SPA, BAY, LOM, OFL were tested by IMDS on guinea pig (96). Skin photoirritation was evaluated and scored by the appearance of erythema and swelling of the mice ears at various times after irradiation (91). The phototoxic potentials of 6,8-dihalogenated FQs LOM, SPA, FLE, CLI and of 6-FQs CIP, NOR, LEV and Tosufloxacin (TOS) are influenced not only by the substituent at position 8 but also by that at position 1.…”

Section: Lipids Membrane Damage Cytotoxicity Irritation and Inflammentioning

confidence: 99%

“…CIP photocytotoxicity was confirmed by a panel of tests including NR and MTT (3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide) assays (84). In in vivo experiments using ear analysis and NR cell test of rodents, LOM and SPA were also found to be photocytotoxic (91). LOM, GAT, SPA, PEF, CIP, OFL photocytotoxicity was evaluated by the Photo Hen Egg Test‐C Chorioallantoic Membrane model (92).…”

mentioning

confidence: 99%

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Photosensitization Reactions of Fluoroquinolones and Their Biological Consequences

Guidi

Bracchitta

Catalfo

2011

Photochem & Photobiology

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This review focuses on damage photosensitized by the fluoroquinolone (FQ) antibacterial drugs. Different models are employed to study biosubstrate photodamage mediated by FQs (organisms, cells, isolated biomolecules and super molecules). Being that the effect of environment (polarity of the medium, ions, pH, binding with bio-molecules, etc.) is crucial in FQ photochemistry, photobiological reactions can be consequently dramatically influenced. Thus, the photosensitization processes induced by FQs are here discussed taking into account that such extensive and cross-targeted pathological implications request an excursus covering photosensitization in systems of increasing molecular complexity. In vivo and in vitro evidences for photoallergy, phototoxicity, photomutagenesis and photocarcinogenesis mediated by FQs are discussed.

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Section: Lipids Membrane Damage Cytotoxicity Irritation and Inflammentioning

confidence: 99%

mentioning

confidence: 99%

Photosensitization Reactions of Fluoroquinolones and Their Biological Consequences

Guidi

Bracchitta

Catalfo

2011

Photochem & Photobiology

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“…Hayvanlar topikal ya da sistemik olarak test maddesine ve uygun dozlarda UVA'ya maruz bırakılır (38). Eritem ve ödem oluşumu 0-4 arasında skorlanır ve 72 saatlik gözlem boyunca maksimum skorun hayvan başına ortalaması alınır.…”

Section: In Vivo Fototoksisite Testleriunclassified

Kozmetik Ürünlerin Fototoksik Etkileri: Mekanizması ve Alternatif Test Metotları

Köse¹,

Erkekoğlu²,

Sabuncuoğlu³

et al. 2017

Marmara Pharmaceutical Journal

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“…The puppies are especially sensitive to developing cartilage lesions due to fluoroquinolones [90–92]. The toxicological profile of fluoroquinolones got more complex with the increasing number of compounds and frequent clinical use, and adverse effects as convulsions [93], photophobia [94], and ocular toxicity related to lens (in dogs) [95] and retina (in cats) [96, 97] have been described. These adverse effects are mostly seen after prolonged administration or high doses and after preclinical safety evaluations [96, 98].…”

Section: Antibiotic Therapy and Teratogenic Risk During Canine Andmentioning

confidence: 99%

Antibiotic Treatment of Dogs and Cats during Pregnancy

Rebuelto

Loza

2010

Veterinary Medicine International

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The use of pharmacological agents in pregnant females poses a major clinical challenge due to the marked physiological changes that may modify the pharmacokinetics of drugs and to the potential effects on the fetus. The purpose of this paper is to review briefly our knowledge on the use of antibacterial drugs during pregnancy and to provide information for the judicious selection of an antimicrobial treatment for use in pregnant bitches and queens. The risk to the fetus is a result of the ability of a drug to reach the fetal circulation and to produce toxic effects. The placenta functions as a barrier that protects the fetus due to the presence of transporters and metabolising enzymes; however, during pregnancy, the presence and activity of both enzymes and transporters may change. Antimicrobial agents that have been shown to be safe for use during pregnancy include betalactams, macrolides, and lincosamides. Pharmacotherapy during pregnancy in all species may affect adversely the developing fetus; therefore, it should be avoided when possible.

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Comparative study of skin phototoxicity with three drugs by an in vivo mouse model

Abstract: ABSTRACTin vitro and in vivo

Cited by 20 publications

References 5 publications

Photosensitization Reactions of Fluoroquinolones and Their Biological Consequences

Photosensitization Reactions of Fluoroquinolones and Their Biological Consequences

Kozmetik Ürünlerin Fototoksik Etkileri: Mekanizması ve Alternatif Test Metotları

Antibiotic Treatment of Dogs and Cats during Pregnancy

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