Comparative Study of Some Antibiotics on Biochemical Changes in Plasma of the Sharptooth Catfish Clarias Gariepinus.

Abstract

C iprofloxacin (15 mg/kg body weight), amoxycillin (50 mg/kg body weight) and ampicillin (80 mg/kg b. wt.) administered orally to male sharptooth catfish Glorias gariepimts 3 times, every 72 hours intervals. Plasma samples were taken for three successive days after the last dose the most important results were : t) Plasma glucose levels were significantly elevated in fish administered ciprofloxacin and amoxycillin at the 3 days studied and ampicillin at the 3 rd day. In contrast, hypoglycemia observed in the first two days in plasma of C. gariepinus administered ampicillin. 2) Significant hyperproteinaemia was observed in fish groups administered bertfer etpfefkweaein and amoxycillin antibiotics during the three days studied. Ampicillin showed a significant highest value at the second day, while the values at both 1 st and 3 rd days showed significant lower values. 3) Administration of the three antibiotics significantly raised the plasma urea in the three days studied except the 2 nd and 3 rd days in fish administrated amoxycillin and ampicillin respectively. Also, increased plasma concentrations of uric acid and creatinine in C. gariepinus administered the three antibiotics at the three days studied were recorded. 4) The AST and ALT activities in C. gariepinus administered both ciprofloxacin and amoxycillin antibiotics showed significant higher values at the 3 rd day. The slope of rise of AST and ALT activities in both ciprofloxacin and amoxycillin were greater than that of ampicillin that is approximately similar to the control group. So, ciprofloxacin, amoxycillin followed by ampicillin are effective on the liver functions in a decreasing order. This observation is clear in ALT than AST, which indicates that ALT is more sensitive to antibiotic administration. 5) Analysis of ALP activity in all groups of C. gahepinus administered with the three antibiotics in the three periods studied showed significant higher values. The administration of antibiotic may considered as stress factor in the fish even when it used in the prophylactic dose. Glucose and ALT, AST and ALP can used to evaluate the stress condition in fish especially in the farm condition.

Therapeutic effect of Nigella sativa oil and ciprofloxacin against bacterial infection based on interleukin 1β expression and kidney histopathological alterations in Oreochromis niloticus

“…niloticus reflected a significant increase in levels of urea, while in combination between them the level of urea not differed compared to the control (I, A). In agreement, Rizkalla et al, (2003) observed that the level of urea increased due to CFX. As such, our observation may show the combination of NSO and CFX does not affect the urea level compared to use both of them individually as well as this combination does not have a deleterious effect on creatinine levels.…”

“…Each of NSO and CFX in O. niloticus reflected a significant increase in levels of urea, while in combination between them the level of urea not differed compared to the control (I, A). In agreement, Rizkalla et al, (2003) observed that the level of urea increased due to CFX.…”

Safety, tolerability and biological responses of Oreochromis niloticus juveniles upon oral oxolinic acid administration

“…The recommended dose also raised the plasma glucose significantly on day 21. The results of the elevated glucose with doses and the extended dosage gave conclusive indications that OA medication is a chemical stressor similar to those observed in Clarias gariepinus exposed to quinolone antibiotics (Rizkalla et al, 2003). Though the glucose decreased significantly on day 21 POD, the levels were still significantly higher than on day 0.…”

Effect of Clostridium Perfringens Infection on Some Biochemical, Physiological and Pathological Parameters in Oreochromis Niloticus

“…Kotak et al (1994); Bury et al (1997) and Kopp and Hetesa (2000) reponed that exposure of rainbow trout, brown trout and juvenile carp to the liver toxin cyanobacterial caused a dramatic increase in the enzymes ALT and AST released into the bloodstream (an indication of severe liver trauma). Rizkalla el aL (2003) observed an increase in plasma ALT and AST of Clarias gariepinus resulting from liver injury caused by antibiotics and ALT was more sensitive to antibiotic administration. Siau and Ip (1987) mentioned-that AST was at least eight times more active than ALT in the liver of different fish species.…”

“…kidney and intestine of moribund striped bass. Also 'Rizkalla et al (2003) mentioned that the elevated plasma ALP activity in Clarias gariepinus treated with three antibiotics corresponded to an inflammatory reaction of the bile ducts. From the present study, it is concluded that the virulent bacteria cause a high mortality rate among the cultured fish while the drastic effect of the mild bacteria is inflected more on the fish physiological status and as a consequence decreases the farm production.…”