Comparative Study of the Antibacterial Potential of Phragmanthera Capitata (Sprengel) S. Balle (Loranthaceae) Extracts, a Parasitic Plant Collected From Three Host Trees

Flora, Ladoh-Yemeda Christelle; Christian, Ngoule Charles; Pierre, Ngene Jean; Christelle, Ndjip Rosette; Ascension, Nyegue Maximillienne; Minette, Tomedi Eyango; Din, Ndongo

doi:10.36348/sjls.2021.v06i02.001

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“…A growing number of herbal medicines are being introduced into psychiatric practice on the basis of their efficacy and low side effects for the treatment of psychiatric disorders as severe depression and anxiety [14]. Phragmanthera capitata (Loranthaceae) is one of the medicinal plants used in Cameroon for the treatment of several diseases as nerve pain [15]. The mistletoe plant, Phragmanthera capitata (P. capitata) belongs to loranthaceae family and is widespread in Africa especially in Cameroon, Nigeria, Gabon and Côte d'Ivoire [16].…”

Section: Introductionmentioning

confidence: 99%

“…Cash crops such as avocado, cocoa, coffee, citrus appear strongly parasitized by Phragmanthera capitata [17]. This plant is known under several names according to the localities in Cameroon: Lihok (Bassa), Kolo'o me tobo (Ewondo), Torikoué (Bakoko) [15]. Phytochemical studies of Takem and colleagues revealed that Phragmanthera capitata harvested from avocado tree possess high presence of terpenoids and tannins; moderate presence of saponins, glycosides, anthraquinones and flavonoids; and low presence of alkaloids and phenols.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Phragmanthera capitata (Loranthaceae) on a model of anxiety-like behaviours induced by chronic immobilization stress in mice

Roger Sebastien Ndjock,

Fleur Clarisse Okomolo Moto,

Jean Pierre Omam Omam

et al. 2023

GSC Adv. Res. Rev.

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This work aims to evaluate the anxiolytic-like effects of Phragmanthera capitata in a model of chronic immobilization stress in mice. Groups of mice were treated in ten consecutive days as follows: a normal control group (NaCl 0.9% per os), a negative control group (chronic immobilization stress + NaCl 0.9% per os), three test groups that were submitted to chronic immobilization stress (CIS) and received three doses of the plant (25, 125, and 250 mg/kg, p.o), and a positive control group (chronic immobilization stress + diazepam 2 mg/kg, i.p). Open field and dark/light tests were used for the evaluation of anxiolytic effects. Antioxidant activities and the involvement of gabaergic neurotransmission were determined by measuring the levels of malondialdehyde (MDA), reduced glutathione (GSH), catalase (CAT), gamma amino butyric acid (GABA), and GABA-transaminase (GABA-T) in the brain. Our results show that the highest dose of Phragmanthera capitata induced a significant increase (p < 0.001) of time spent in the centre, number of crossing and number of grooming in the open field test and a significant increase (p < 0.001) of time spent in the light compartment and the latency of the first escape in the light compartment of the dak/light test. The level of MDA and the activity of GABA-T were signiﬁcantly decreased by the Phragmanthera capitata while reduced GSH, CAT and GABA, levels were increased. These results suggest that Phragmanthera capitata possesses anxiolytic-like effects that may be supported by its antioxidant activities and or the GABA neurotransmission.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%