Comparative study of the antioxidant and anti-inflammatory effects of the natural coumarins 1,2-benzopyrone, umbelliferone and esculetin: in silico, in vitro and in vivo analyses

Leal, Luana Eloísa; Moreira, Evelyn Silva; Correia, Bruna; Bueno, Paulo Sérgio Alves; Comar, Jurandir Fernando; Sá‐Nakanishi, Anacharis Babeto de; Cuman, Roberto Kenji Nakamura; Bracht, Adelar; Bersani-Amado, Ciomar Aparecida; Bracht, Lívia

doi:10.1007/s00210-023-02606-2

Cited by 4 publications

(1 citation statement)

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“…An important indication for bromelain therapy is the reduction of postoperative and post-traumatic swelling [8,9]. Previous studies have shown a correlation of this phytotherapeutic medicine with decreases in COX2 concentration [10].…”

Section: Discussionmentioning

confidence: 99%

Reduction of Post-Surgical Facial Edema Following Bromelain and Coumarin Intake in Traumatology: A Prospective Study with 100 Patients

Consorti,

Monarchi,

Paglianiti

et al. 2024

JCM

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Background: Bromelain and coumarins are recognized as safe and effective therapeutic agents, used by individuals to treat ailments such as postoperative edema, inflammation and other diseases. Bromelain has been proven to be well absorbed by the body after oral administration, and it has no major side effects even after prolonged use. The purpose of this study is to evaluate the effectiveness of bromelain and other nutraceuticals in reducing post-surgical swelling, pain and the need of anti-inflammatory drugs in maxillofacial post-traumatic surgery. Methods: This prospective open-label study was conducted on patients undergoing surgery for trauma of the maxillofacial area. One hundred patients were selected and divided into two groups: one group who underwent therapy with bromelain, Aesculus hippocastanum and Melilotus officinalis and a control group that was not given the drug in postoperative therapy. Results: Patients in the experimental group showed a reduction of edema in the first and second postoperative weeks, a faster complete reduction of facial edema and a lower reduction in maximum mouth opening and needed less anti-inflammatory therapy to control pain. Conclusions: These findings seem to provide evidence that Brovas® may be effective in improving postoperative edema outcomes in patients undergoing surgical treatment of facial fractures.

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Section: Discussionmentioning

confidence: 99%