Comparative Study of the Bronchospasmolytic Effect of Fenoterol (0.2 mg) and Salbutamol (0.4 mg) as Powder inhalations in 20 Patients with Reversible Bronchial Obstruction

Maesen, F. P. V.; Smeets, J. J.; Bernsen, Roos; Cornelissen, P. J. G.

doi:10.1159/000194628

Respiration

1984

DOI: 10.1159/000194628

|View full text |Cite

Comparative Study of the Bronchospasmolytic Effect of Fenoterol (0.2 mg) and Salbutamol (0.4 mg) as Powder inhalations in 20 Patients with Reversible Bronchial Obstruction

F. P. V. Maesen

J. J. Smeets

Roos Bernsen

et al.

Abstract: In a double-blind crossover study, the effects of fenoterol powder inhaled from capsules (0.2 mg) and the powder inhaler with salbutamol capsules (0.4 mg) were compared. A single dose of each was administered on 2 subsequent days in random order. The effects on lung function test results were followed from 15 to 360 min after administration. Apart from the overall comparison, special attention was paid to the beginning and the end of the test periods. Statistically significant differences were found only in a … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1985

1999

Publication Types

Select...

Article4

Relationship

Self Cite1

Independent3

Authors

Journals

Cited by 4 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The rationale of this investigation is based on former experiences with fenoterol inhalation powder, which, just as ipratropium inhalation powder, also consists of glucose powder. Several studies have demonstrated that fenoterol inhalation powder (200 ng) is equipotent to the same dose inhaled from the fenoterol pressure aerosol (1,6,8,9).…”

mentioning

confidence: 99%

Ipratropium Bromide (Atrovent®) as Inhalation Powder

Maesen

Smeets

Bernsen

et al. 1986

Allergy

Self Cite

View full text Add to dashboard Cite

The bronchospasmolytic effects of 40 micrograms ipratropium bromide (Atrovent) given either as an aerosol (2 puffs of 20 micrograms) or as a powder inhalation were compared in a double-blind cross-over study. Following a randomisation list the drug was given on 2 successive days to 20 patients with stable bronchospasm in whom it had previously been shown that the bronchial obstruction was reversible after administration of 40 micrograms ipratropium bromide as an aerosol (with an increase over the baseline value of the FEV1 of at least 15% 1 h after drug administration). The effects of the two presentations of ipratropium bromide were followed by respiratory function tests from 15 min to 6 h after administration of the drug. With both formulations excellent bronchospasmolytic effects were noted in each of the parameters measured. The peak of the effects was noted approximately 1 h after the inhalations. Six hours later there was still a significant improvement in comparison with the baseline values. There was no significant difference between the results with the two different formulations. Inhalation powder of ipratropium bromide was well tolerated and there were no complaints of irritation or coughing. It would appear, therefore, to be a valuable alternative to the pressure aerosol.

show abstract

mentioning

confidence: 99%

Ipratropium Bromide (Atrovent®) as Inhalation Powder

Maesen

Smeets

Bernsen

et al. 1986

Allergy

Self Cite

View full text Add to dashboard Cite

show abstract

Effect of different inhaled bronchodilators on recovery from methacholine-induced bronchoconstriction in asthmatic children

et al. 1999

View full text Add to dashboard Cite

Two hundred fourteen children with mild to moderate asthma were studied to determine bronchodilator effects 5 min after administration of five different metered dose inhaler (MDI) aerosol formulations available in our country, and results were compared to placebo. Methacholine bronchial challenge was performed by the tidal breathing method, using increasing concentrations until a fall in forced expired volume in 1 s (FEV1) ≥20% was achieved (PC20). Immediately after FEV1 had fallen 20% or more, children were randomly allocated into 1 of 6 groups to receive: salbutamol 200 μg (S), fenoterol 200 μg (F), salbutamol 200 μg + beclomethasone 100 μg (S + B) , fenoterol 200 μg + ipratropium bromide 80 μg (F + IB), salmeterol 50 μg (SM), and placebo (P). The bronchodilator effect was determined by measuring FEV1 5 min after inhalation of medications. Nonparametric tests were used for statistical analysis. The six groups were similar in anthropometric and in respiratory characteristics. All five inhaled aerosols containing beta‐agonists caused a significant bronchodilator effect as compared to placebo. However, the effect was significantly greater in the groups treated with F or F + IB (P < 0.05) compared to other formulations. We conclude that the five types of aerosols used in this study are able to reverse methacholine‐induced bronchoconstriction 5 min after inhalation of a bronchodilator. Pediatr Pulmonol. 1999; 28:125–129. © 1999 Wiley‐Liss, Inc.

show abstract

A comparison of inhaled powders of fenoterol and salbutamol in asthma

Asher

Dunn

1985

J Paediatrics Child Health

View full text Add to dashboard Cite

The present study compares fenoterol and salbutamol powders (0.2 mg). Twenty‐five children with frequent episodic asthma, aged 4–9 years, entered a double‐blind, randomized, crossover, placebo controlled study. On each of three days fenoterol, salbutamol or placebo were given in random order. Lung function testing and other observations were made before and at set intervals up to 4 h after the treatments. Both inhaled powders increased the forced expired volume in 1 s and the maximum mid‐expiratory flow rate significantly above placebo effect. No side effects were observed and there were no significant differences in bronchodilator efficacy between fenoterol and salbutamol.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Comparative Study of the Bronchospasmolytic Effect of Fenoterol (0.2 mg) and Salbutamol (0.4 mg) as Powder inhalations in 20 Patients with Reversible Bronchial Obstruction

Cited by 4 publications

References 7 publications

Ipratropium Bromide (Atrovent®) as Inhalation Powder

Ipratropium Bromide (Atrovent®) as Inhalation Powder

Effect of different inhaled bronchodilators on recovery from methacholine-induced bronchoconstriction in asthmatic children

A comparison of inhaled powders of fenoterol and salbutamol in asthma

Contact Info

Product

Resources

About