Comparative study of the cardioprotective effects of local and remote preconditioning in ischemia/reperfusion injury

Ahmed, Lamiaa A.; Salem, Hesham A.; Attia, Amina S.; Agha, Azza M.

doi:10.1016/j.lfs.2011.11.007

Cited by 8 publications

(12 citation statements)

References 48 publications

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“…; Ahmed et al . ). The amount of tissue subjected to ischaemia during RIPC is another very important determinant of RIPC effectiveness.…”

Section: Discussionmentioning

confidence: 97%

“…Much less is known about the effects of RIPC on early phase of ischaemic arrhythmogenesis. The recent study by Ahmed et al (2012) demonstrated that RIPC induced by several 5-min episodes of limb ischaemia in rats had no significant effect on arrhythmia score. Our data corroborate these findings because RIPC induced by 15-min MAO and 15-min reperfusion prior to test ischaemia had no influence on early ischaemic arrhythmias.…”

Section: Anti-arrhythmic Effect Of Lipc and Ripcmentioning

confidence: 99%

“…The data on this issue are still limited. Ahmed et al (2012) found in the rat model that myocardial injury was significantly reduced only when three episodes of 5-min femoral artery occlusion were used. No protection was evident with one, two or four episodes of RIPC.…”

Section: The Effect Of Ripc Protocol On the Extent Of Cardiac Protectionmentioning

confidence: 99%

“…While the earlier studies on RIPC usually explored the effect of a single 10-to 15-min episode of remote ischaemia on myocardial tolerance to IRI (Gho et al 1996;Birnbaum et al 1997;Pell et al 1998;Weinbrenner et al 2002), most of the recent experimental and also clinical studies used repeated 5-min cycles of RIPC (Heinen et al 2011;Ahmed et al 2012;Jones et al 2013;Hong et al 2014). Does it matter whether a single or multiple cycles of RIPC are used and to what extent the protocol of RIPC affects the outcome?…”

Section: The Effect Of Ripc Protocol On the Extent Of Cardiac Protectionmentioning

confidence: 99%

“…From the clinical viewpoint, it is more feasible to use shorter episodes of limb ischaemia. However, it is important to realize that the overall reduction in infarct size due to RIPC is usually less pronounced than that due to LIPC (Weinbrenner et al 2002;Ahmed et al 2012). The amount of tissue subjected to ischaemia during RIPC is another very important determinant of RIPC effectiveness.…”

Section: The Effect Of Ripc Protocol On the Extent Of Cardiac Protectionmentioning

confidence: 99%

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Remote vs. local ischaemic preconditioning in the rat heart: infarct limitation, suppression of ischaemic arrhythmia and the role of reactive oxygen species

Galagudza

Sonin

Власов

et al. 2016

Int J Experimental Path

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SUMMARYThe unmet clinical need for myocardial salvage during ischaemia-reperfusion injury requires the development of new techniques for myocardial protection. In this study the protective effect of different local ischaemic preconditioning (LIPC) and remote ischaemic preconditioning (RIPC) protocols was compared in the rat model of myocardial ischaemia-reperfusion, using infarct size and ischaemic tachyarrhythmias as end-points. In addition, the hypothesis that there is involvement of reactive oxygen species (ROS) in the protective signalling by RIPC was tested, again in comparison with LIPC. The animals were subjected to 30-min coronary occlusion and 90-min reperfusion. RIPC protocol included either transient infrarenal aortic occlusion (for 5, 15 and 30 min followed by 15-min reperfusion) or 15-min mesenteric artery occlusion with 15-min reperfusion. Ventricular tachyarrhythmias during test ischaemia were quantified according to Lambeth Conventions. It was found that the infarct-limiting effect of RIPC critically depends on the duration of a single episode of remote ischaemia, which fails to protect the heart from infarction when it is too short or, instead, too prolonged. It was also shown that RIPC is ineffective in reducing the incidence and severity of ischaemia-induced ventricular tachyarrhythmias. According to our data, the infarct-limiting effect of LIPC could be partially eliminated by the administration of ROS scavenger N-2-mercaptopropionylglycine (90 mg/kg), whereas the same effect of RIPC seems to be independent of ROS signalling.

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“…; Ahmed et al . ). The amount of tissue subjected to ischaemia during RIPC is another very important determinant of RIPC effectiveness.…”

Section: Discussionmentioning

confidence: 97%

Section: Anti-arrhythmic Effect Of Lipc and Ripcmentioning

confidence: 99%

Section: The Effect Of Ripc Protocol On the Extent Of Cardiac Protectionmentioning

confidence: 99%

Section: The Effect Of Ripc Protocol On the Extent Of Cardiac Protectionmentioning

confidence: 99%

Section: The Effect Of Ripc Protocol On the Extent Of Cardiac Protectionmentioning

confidence: 99%

See 3 more Smart Citations

Remote vs. local ischaemic preconditioning in the rat heart: infarct limitation, suppression of ischaemic arrhythmia and the role of reactive oxygen species

Galagudza

Sonin

Власов

et al. 2016

Int J Experimental Path

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Omega 3 chronic supplementation attenuates myocardial ischaemia‐reperfusion injury through reinforcement of antioxidant defense system in rats

Castillo

Arias

Farías

2013

Cell Biochemistry & Function

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Currently, controversial clinical data about the protective effects in the consumption of n-3 polyunsaturated fatty acids (PUFAs) in ischaemic heart diseases exist. Improved myocardial resistance to ischaemia-reperfusion (IR) injury results in non-lethal myocardial infarction, which is a relevant factor in the myocardial function. We hypothesized that chronic supplementation with PUFAs reduced infarct size (IS) and induced an improvement on oxidative stress-related parameters in IR model. Rats were supplemented with two doses of PUFAs D1 (n = 7) (0.6 g kg(-1) d(-1) ) and D2 (n = 7) (1.2 g kg(-1) d(-1) ) for 8 weeks. Control group (n = 7) received only standard diet. In ex vivo model, all rat hearts were subjected to 30 min of global ischaemia followed by 120 min of reperfusion. The IS and left ventricular function were assessed. Lipid peroxidation, reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio and antioxidant enzyme activity were measured in the whole heart. The results show a reduction in IS in a dose-dependent manner with PUFAs D1 (30.6%) and D2 (48.5%) and higher values of left ventricular developed pressure, at the end of the reperfusion, for each dose, respectively (p < 0.05). The two PUFAs groups showed higher values of GSH/GSSG ratio and lipid peroxidation, and higher values of activity of antioxidant enzymes catalase, superoxide dismutase and glutathione peroxidase at basal condition (p < 0.05). At the end of reperfusion, the GSH/GSSG ratio and antioxidants enzyme activity did not show a significant drop in their values (p > 0.05). These findings suggested that the supplementation with PUFAs induces cardioprotection against IR injury, associated with reinforcement of the antioxidant defense system.

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The Phenomenon of Remote Preconditioning of the Heart and Its Main Manifestations

Maslov

Podoksenov

Tsibulnikov

et al. 2017

Neurosci Behav Physi

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Comparative study of the cardioprotective effects of local and remote preconditioning in ischemia/reperfusion injury

Cited by 8 publications

References 48 publications

Remote vs. local ischaemic preconditioning in the rat heart: infarct limitation, suppression of ischaemic arrhythmia and the role of reactive oxygen species

Remote vs. local ischaemic preconditioning in the rat heart: infarct limitation, suppression of ischaemic arrhythmia and the role of reactive oxygen species

Omega 3 chronic supplementation attenuates myocardial ischaemia‐reperfusion injury through reinforcement of antioxidant defense system in rats

The Phenomenon of Remote Preconditioning of the Heart and Its Main Manifestations

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