Comparative study of the concentration of salivary and blood glucose in type 2 diabetic patients

Vasconcelos, Ana Carolina Uchôa; Soares, Maria Sueli Marqués; Almeida, Paulo César de; Soares, Teresa

doi:10.2334/josnusd.52.293

Cited by 98 publications

(95 citation statements)

References 20 publications

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“…This was in agreement with studies conducted by Aydin, 20 Jurysta et al, 23 Vasconcelos et al, 16 and Naik et al…”

Section: Discussionsupporting

confidence: 83%

“…15 Glucose, a small molecule can easily diffuse through semipermeable membranes thus increasing the salivary glucose levels, which ultimately results in consequent loss of homeostasis and greater susceptibility to diseases in the oral cavity. 14,[16][17] There is lack of consensus among different authors on the utility of saliva for monitoring glycemic control. Thus the aim of the present study was to establish saliva as a diagnostic tool for monitoring glycemic control in diabetic patients.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of Salivary and Serum Glucose Levels in Diabetic Patients

Gupta

Sandhu²,

Bansal

et al. 2014

J Diabetes Sci Technol

106

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Diabetes mellitus is a group of complex multisystem metabolic disorders characterized by relative or absolute insufficiency of insulin secretion and/or concomitant resistance to the metabolic action of insulin on target tissues. 1 The worldwide explosion of this chronic ailment is a major health care burden. The number of people globally with diabetes are projected to rise to 439 million (7.7%) by 2030. 2 Currently, India has 41 million diabetics, and this number is expected to increase to 70 million by 2025. The increased number of diabetics in India is likely due to unprecedented rates of urbanization and lifestyle changes. 3 The increased morbidity and mortality of diabetic patients is mostly attributed to complications of the disease. Hyperglycemia is the immediate metabolic consequence of diabetes, and chronic hyperglycemia leads to several events that promote structural changes in tissues. 1,4 A high prevalence of wide spectrum oral alterations associated with diabetes has been described in literature. To minimize the risk of complications associated with this disease, it is necessary to regularly monitor the glucose levels of diabetic patients. The important aspect in glycemic control is the frequent monitoring of blood glucose levels. 5 Various biofluids that are used to monitor glucose levels include blood and urine. The choice of blood as a diagnostic fluid for clinical testing is clear-cut considering its close relationship to the homeostasis of the body. Because blood circulates throughout all organs, its chemical makeup is a composite of nearly all metabolic processes occurring in the 552673D STXXX10.

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“…This was in agreement with studies conducted by Aydin, 20 Jurysta et al, 23 Vasconcelos et al, 16 and Naik et al…”

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Comparison of Salivary and Serum Glucose Levels in Diabetic Patients

Gupta

Sandhu²,

Bansal

et al. 2014

J Diabetes Sci Technol

106

View full text Add to dashboard Cite

show abstract

“…Xerostomia and hyposalivation reportedly occur in 12.5 and 45% of diabetics, respectively, but in only 5 and 2.5% of healthy persons (12). Factors underlying the potential association of dental caries with diabetes have received comparatively little research attention (13).…”

mentioning

confidence: 99%

Oral Bacterial Communities in Individuals with Type 2 Diabetes Who Live in Southern Thailand

Kampoo

Teanpaisan

Ledder

et al. 2014

Appl Environ Microbiol

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Type 2 diabetes mellitus is increasingly common in Thailand and elsewhere. In the present investigation, the bacteriological composition of saliva and supragingival plaque in Thai diabetics with and without active dental caries and in nondiabetics was determined by differential culture and eubacterial DNA profiling. Potential associations between fasting blood sugar and glycosylated hemoglobin (biomarkers of current and historical glucose control, respectively) with decayed, missing, and filled teeth and with salivary Streptococcus and Lactobacillus counts were also investigated. The incidence of active dental caries was greater in the Thai diabetics than in nondiabetics, and the numbers of total streptococci and lactobacilli were significantly higher in supragingival plaque from diabetics than in nondiabetics. Lactobacillus counts in the saliva and supragingival plaque of diabetics with active caries were significantly higher than those in diabetics without active caries. Oral eubacterial DNA profiles of diabetic versus nondiabetic individuals and of diabetics with active caries versus those without active caries could not be readily differentiated through cluster analysis or multidimensional scaling. The elevated caries incidence in the Thai diabetics was positively associated with numbers of bacteria of the acidogenic/acid-tolerant genera Streptococcus and Lactobacillus. Lactobacillus bacterial numbers were further elevated in diabetics with active caries, although salivary eubacterial DNA profiles were not significantly altered.

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“…[17] or "Do you get the feeling of dry mouth frequently?" [34], whereas others used several questions: "Do you have the feeling of dry mouth frequently, " "Do you get the feeling of dry mouth during meals?" and "Do you have difficulty swallowing food without the help of a liquid substance?"…”

Section: Discussionmentioning

confidence: 99%

Meta-Analysis of Prevalence of Xerostomia in Diabetes Mellitus

Lessa

Pires²,

Ceretta

et al. 2015

Int Arch Med

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Background: As with other complications of diabetes mellitus, the occurrence of dry mouth can lead to a poor quality of life. Therefore, this study aimed to identify the prevalence of xerostomia in patients with diabetes mellitus through a systematic review and meta-analysis. Method: Systematic review and meta-analysis.Results: After the screening process, 23 studies were included in the meta-analysis. Overall, the incidence of dry mouth was investigated in 1979 people with diabetes (cases) and 1225 controls. The global prevalence of diabetes in xerostomia was 42.22% (95% CI: 33.97%-50.92%). In the analysis by specific subtype, the overall prevalence was 37.42% (95% CI: 22.33%-55.44%) among individuals with Type 1 diabetes and 46.09% (95% CI: 23.99%-69.85%) among those with type 2 diabetes. The prevalence of xerostomia found in Asia (49.01%; 95% CI: 32.08%-66.16%) was higher than that found in Europe (40.04%; 95% CI: 29.58%-51.50%) and America (38.39%; 95% CI: 23.63%-55.65%). Analysis of the case-control studies showed a statistically significant association between xerostomia and diabetes mellitus (OR=3.15; 95% CI: 2.11-4.70; p<0.001).

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Comparative study of the concentration of salivary and blood glucose in type 2 diabetic patients

Cited by 98 publications

References 20 publications

Comparison of Salivary and Serum Glucose Levels in Diabetic Patients

Comparison of Salivary and Serum Glucose Levels in Diabetic Patients

Oral Bacterial Communities in Individuals with Type 2 Diabetes Who Live in Southern Thailand

Meta-Analysis of Prevalence of Xerostomia in Diabetes Mellitus

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