Comparative study of the effect of PTH (1–84) and strontium ranelate in an experimental model of atrophic nonunion

Núñez, María Isabel Pérez; Blanco, D. Ferreño; Fernández, A.; Casado, Julio; Sánchez-Crespo, M.R.; Gallego, M. De la Red; Carra, A. Pascual; López, T. Rodriguez; Cavia, S. Diego; Zarzalejo, C. Garcés; Fernández, María Concepción López; Martínez, Elena; Carrascal, I.; Moral, José Antonio Riancho

doi:10.1016/j.injury.2015.10.007

Cited by 7 publications

(2 citation statements)

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“…To date, there have been only three studies on the use of PTH in experimental nonunion or refractory fracture models [ 29 – 31 ]. Lin et al made a murine atrophic nonunion model by creating an open osteotomy in the midshaft femur, followed by distraction using a clip to maintain a fracture gap of 1.7-mm [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…Although PTH (1–34) treatment produced significant increases in callus size and strength, it did not increase union rate at week 6 compared to the control group, which was assessed histologically and radiologically. In the study of Perez-Nunez et al, a model of atrophic nonunion with a 2-mm gap was created in a rat’s femur [ 31 ]. Rats were treated with PTH (1–84) at a dose of 30 μg/kg daily, 5 days a week for 12 weeks.…”

Section: Discussionmentioning

confidence: 99%

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Triweekly administration of parathyroid hormone (1–34) accelerates bone healing in a rat refractory fracture model

Kumabe

Lee

Waki

et al. 2017

BMC Musculoskelet Disord

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BackgroundSome reports have shown that intermittent parathyroid hormone (PTH) (1–34) treatment for patients with delayed union or nonunion have led to successful healing. In this study, we investigated whether systemic intermittent administration of PTH (1–34) has a beneficial effect on bone healing in a rat refractory fracture model.MethodsWe created a refractory femoral fracture model in 32 rats with periosteal cauterization that leads to atrophic nonunion at 8 weeks after surgery. Half the rats received subcutaneous intermittent human PTH (1–34) injections at a dosage of 100 μg/kg, thrice a week for 8 weeks. The other half received the vehicle only. At 8 weeks after fracture, radiographic, histological and mechanical assessments were performed.ResultsRadiographic assessments showed that the union rate was significantly higher in the PTH group than in the control group (P < 0.05). The degree of fracture repair as scored using the Allen grading system in histological assessment was significantly greater in the PTH group than in the control group (P < 0.05). The ultimate stress and stiffness measurements were significantly greater in the PTH group than in the control group (p < 0.05).ConclusionsWe demonstrated that triweekly administration of PTH (1–34) increased union rate and accelerated bone healing in a rat refractory fracture model, suggesting that systemic administration of PTH (1–34) could become a novel and useful therapy for accelerating fracture healing in patients at high risk of delayed union or nonunion.Electronic supplementary materialThe online version of this article (10.1186/s12891-017-1917-2) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%