Comparative study of the effect of taurine, caffeine, and /or paracetamol on male fertility and teratogenicity in rats

Abstract

Caffeine (CF) is one of the popular nutrients that have been implicated as a risk factor for infertility. Taurine (TAU) is the most abundant free amino-acid present in mammalian tissues and cells. Paracetamol (PCM) is an effective oral analgesic. The present study represented to evaluate the effects of CF, TAU and /or PCM on male fertility in rat and the development of their fetuses. The 1 st group was kept as a normal control received distilled water. The 2 nd , 3 rd and 4 th groups received orally 250 mg / kg, 40 mg / kg and 270 mg/ kg of TAU, CF and PCM, respectively. In addition, the 5 th , 6 th , 7 th , and 8 th groups received TAU+CF, TAU+PCM, CF+PCM and TAU+CF+PCM, respectively, for 45 th consecutive days. Then blood samples were taken to determine the testosterone and FSH level, and total pro-oxidant. Moreover, in testes, malondialdehyde and nitrite/nitrate were estimated. Besides, the abnormality of sperms, sperm counts and percentage of sperm motilities were evaluated. These males were allowing to mated with untreated female rats to determined the rate of pregnancy and study any malformation in their fetuses. The results revealed that each of CF and/ or PCM decreased the weights of fetuses, as well as sperm counts and motilities significantly. Besides, percentages of head and tail abnormalities were increased in CF and/or PCM. The histopathological examination revealed presence of marked degenerative changes in testes in CF and/or PCM-treated groups. In conclusion, we observed that TAU almost improved undesirable effects induced by PCM or/and CF.

Gonadal sperm reserves and testosterone profile of Wistar rats treated with Taurine following Cypermetrin toxicity

“…Attention has to be given to the tail of the epididymis which is a storage site since sperm reserves are directly related to sperm count. The observations on the testicular sperm reserves and the tail segment of the epididymis contradicts the report that taurine is vital for reproduction (Ebtehal, 2018). Combination of taurine and cypermethrin at the two doses tested did not enhance paired sperm reserves in all the segments of the epididymis and the testes.…”

“…The diminished sperm reserves observed may be attributed to the osmo-regulatory property of taurine. Taurine has been credited as a neurotransmitter, osmo-regulator and antioxidant in most tissues (Ebtehal, 2018). It has been reported as one of the osmolytes of semen that cause volume regulation.…”

“…It is credited as a neurotransmitter, osmo-regulator and antioxidant in most tissues. Taurine is vital for reproduction, development of the central nervous system, the retina and calcium modulation (Ebtehal, 2018). In addition, it is necessary in cell membrane stabilization in the heart, muscle, retina, CNS and immune system (Harris, 2012).…”

The Impact of 2-Aminoethanesulfonic Acid, Guaranine Methyl Theobromine 1, 3, 7-Trimethylxanthine Theine and/or Isobutylphenyl Propionic Acid on Masculine Fecundity, and Morphopathological Disorders in Rats

“…Moreover, recently, the use of energy drinks has been identified as a high CAF source which raises concerns on the wide use of these beverages. In addition, energy drinks overuse has been associated with seizures and arrhythmias [17,18], affect conductance and refractoriness on the heart, resulting in the development of various arrhythmias [19]. Moreover, the consuming pattern of CAF is highly intimate with doping effect.…”