Comparative Study of the Efficacy of Curcumin and Turmeric Oil as Chemopreventive Agents in Oral Submucous Fibrosis: A Clinical and Histopathological Evaluation

Colloidal Submicron-Particle Curcumin Exhibits High Absorption Efficiency—A Double-Blind, 3-Way Crossover Study—

“…Meriva improved curcumin bioavailability and joint pain and function in osteoarthritis (OA) patients (30), could alleviate side effects associated with chemo-and radiotherapy in patients under treatment for solid tumors (24), had pain-relieving properties (34), was effective for patients with benign prostatic hyperplasia (BPH) (35), and was effective in the management of central serous chorioretinopathy (36,37), diabetic microangiopathy and retinopathy (38), and chronic anterior uveitis (39). Some clinical studies showed that BCM-95 had beneficial effects on patients with rheumatoid arthritis (RA) (40) and oral submucous fi brosis (OSMF) (41). Theracurmin was reported to be able to potentially improve the age-related decline in endothelial function (26) and systolic blood pressure (27) in postmenopausal women.…”

“…So, in this study, volunteers were administered with 180 mg of Theracurmin. From 1 to 8 capsules (approximately 260-2,080 mg of curcumin) BCM-95 were used for clinical trials (20,28,32,41). Since even 1 capsule had benefi cial effects on patients with RA, we used 1 capsule (260 mg of curcumin) in this study to adjust the curcumin level in all groups.…”

Curcumin as a Cure; Comparison of the Efficacy of Systemic and Topical Administration of Curcumin in Oral Submucous Fibrosis Patients: A Cross-Sectional Study

“…The authors stated that conventional method of intralesional steroids was better in improving tongue protrusion. However, Deepa das et al [12] in her study of forty eight OSMF patients demonstrated better increase in tongue protrusion for patients under turmeric administration. It is of interest to note that, none of the patients in Groups A and B presented a deterioration of their signs and symptoms nor a malignant transformation.…”

“…Along with the inhibition of arachidonic acid metabolism, they also inhibit superoxide generation, and thus prevent tumor promotion. [12] The increase in mouth opening brought about by treatment with curcumin could be a result of the anti-inflammatory, antioxidant and fibrinolytic properties of curcumin. Turmeric and curcumin are used in Chinese medicine since ages.…”

Turmeric: A Boon to Oral Health

“…29 Turmeric is a beneficial, easily available, and noninvasive form for the treatment of oral submucous fibrosis, and its use leads to a significant decrease in burning sensation. 30,31 Higher dosages of curcumin (up to 6000 mg/day) are effective in reduction of oral lichen planus symptoms in patients.…”