Comparative study of the hydrophobic interaction effect of pH and ionic strength on aggregation/emulsification of Congo red and amyloid fibrillation of insulin

Kasai, Takahiro; Wada, Takashi; Iijima, Tsubasa; Minami, Yoshiko; Sakaguchi, Tomoyo; Koga, Ryotaro; Shiratori, Tomoki; Otsuka, Yuta; Shimada, Yohsuke; Okayama, Yukiko; Goto, Setsuko

doi:10.1016/j.bbadva.2021.100036

Cited by 11 publications

(2 citation statements)

References 59 publications

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“…However, in the acidic conditions (Figure b), the average flux continuously increased from 101.1 to 108.5 L/m 2 ·h at the beginning, and then it reached a plateau, while the CR rejection remained over 99.7% throughout the operation. The high rejection was due to the self-association of CR molecules at a low pH, , which made them become longer and more rigid, while the membrane showed a positive charge as shown in Figure c. Similar performance patterns were observed under alkaline conditions (Figure c), and the average flux increased from 101.7 to 110.2 L/m 2 ·h, slightly higher than that under acidic conditions.…”

Section: Resultssupporting

confidence: 55%

Fabrication of Cellulose Nanofiltration Membranes by Reusing a Binary Solvent of EMIMAc Ionic Liquid and DMSO

Li,

Zhang,

Tan

et al. 2023

Ind. Eng. Chem. Res.

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Cellulose, a sustainable raw material, holds great promise as an ideal candidate for membrane materials. This work focused on establishing a green route for fabricating cellulose nanofiltration membranes by reusing a binary solvent of a mixture of ionic liquid (IL) 1-ethyl-3-methylimidazolium acetate and dimethyl sulfoxide (DMSO). The rheological and thermodynamic properties of cellulose solutions were thoroughly investigated to gain fundamental insights into cellulose membrane formation using a mixture solvent. The morphologies and separation performances of the cellulose membranes were also studied. Based on these results, we successfully developed a cellulose membrane with a remarkable water flux of 101.8 L/m2·h, and the rejections for both Congo Red and Evans Blue were higher than 99.7%. Furthermore, the cellulose membrane demonstrated excellent antifouling performance and stability in long-term operation. Moreover, we conducted an attempt on the recycling and reuse of IL and DMSO, revealing that the structure and separation performance of the cellulose membrane produced using the recovered solvent were comparable to those of the membrane obtained using the original solvent. These results highlighted a sustainable approach to fabricating high-performance cellulose membranes.

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Section: Resultssupporting

confidence: 55%

Fabrication of Cellulose Nanofiltration Membranes by Reusing a Binary Solvent of EMIMAc Ionic Liquid and DMSO

Li,

Zhang,

Tan

et al. 2023

Ind. Eng. Chem. Res.

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“…In particular, the presence of sulfate above 5 mM led to a salting-out effect, with insulin precipitation into aggregates with a high content of α-helix, delaying their conversion into the fibril-forming β-sheets, relative to chloride anions [ 58 ]. Furthermore, at acidic pH, at which insulin is present as a polycation, electrolytes play a key role in screening insulin charges and in enabling the hydrophobic interactions leading to fibrillation [ 59 ]. Clearly, the issue of high ionic strength promoting insulin fibrillation is more relevant to industrial production, storage, and transport of insulin than to physiological conditions where ion homeostasis is tightly controlled.…”

Section: Insulin Fibrillationmentioning

confidence: 99%

Peptide Inhibitors of Insulin Fibrillation: Current and Future Challenges

Rosetti

Marchesan

2023

IJMS

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Amyloidoses include a large variety of local and systemic diseases that share the common feature of protein unfolding or refolding into amyloid fibrils. The most studied amyloids are those directly involved in neurodegenerative diseases, while others, such as those formed by insulin, are surprisingly far less studied. Insulin is a very important polypeptide that plays a variety of biological roles and, first and foremost, is at the basis of the therapy of diabetic patients. It is well-known that it can form fibrils at the site of injection, leading to inflammation and immune response, in addition to other side effects. In this concise review, we analyze the current knowledge on insulin fibrillation, with a focus on the development of peptide-based inhibitors, which are promising candidates for their biocompatibility but still pose challenges to their effective use in therapy.

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Congo red removal from aqueous solution via biosorption onto Trametes trogii‐loaded poly(hydroxyethyl methacrylate) cryogel

Sarıkaya,

Kopar,

Osman

2024

Journal of Polymer Science

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In this study, Trametes trogii‐loaded poly(2‐ hydroxyethyl methacrylate) cryogel (Tt‐PHEMA) was prepared and used as a biosorbent to remove Congo Red (CR), from aqueous solutions. The biomass and Tt‐PHEMA cryogel were characterized with scanning electron microscopy and Fourier Transform infrared spectroscopy. Macroporosity degree (%) and swelling ratio (%) of the Tt‐PHEMA cryogel were determined as 78.3% and 61.04%, respectively. The effect of loaded biomass amount, pH, initial CR concentration, temperature, and contact time were investigated detailedly. The maximum biosorption capacity of Tt‐PHEMA cryogel was 156.71 ± 1.22 mg g−1 at pH 6.0 at 45°C. Biosorption capacity was increased from 125.92 ± 1.524 mg g−1 to 156.71 ± 1.22 mg g−1 with increasing temperature from 25 to 45°C, demonstrating that the biosorption process was endothermic. The biosorption data were well fitted to the Freundlich isotherm and pseudo‐second‐order kinetic models. The negative Gibbs free energy change values showed favorable biosorption. The Tt‐PHEMA cryogel was easily regenerated with ethanol and used repeatedly five times without a significant change in the biosorption capacity. As a result, Trametes trogii‐loaded PHEMA cryogel has an application potential for CR removal from wastewater, taking advantage of interconnected macroporous structure cryogels.

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Comparative study of the hydrophobic interaction effect of pH and ionic strength on aggregation/emulsification of Congo red and amyloid fibrillation of insulin

Cited by 11 publications

References 59 publications

Fabrication of Cellulose Nanofiltration Membranes by Reusing a Binary Solvent of EMIMAc Ionic Liquid and DMSO

Fabrication of Cellulose Nanofiltration Membranes by Reusing a Binary Solvent of EMIMAc Ionic Liquid and DMSO

Peptide Inhibitors of Insulin Fibrillation: Current and Future Challenges

Congo red removal from aqueous solution via biosorption onto Trametes trogii‐loaded poly(hydroxyethyl methacrylate) cryogel

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