Comparative study of the interaction of stereoisomers of dimercaptosuccinic acid with certain metals

Egorova, L. G.; Okonishnikova, I. E.; Nirenburg, V. L.; Postovskii, I. Ya.

doi:10.1007/bf00760842

Cited by 3 publications

(2 citation statements)

References 2 publications

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“…The first goal of this research was to further improve the antimicrobial behavior of SPION through increased water solubility and metal conjugation. It has been previously demonstrated that SPION coated with DMSA are well dispersed in water, cell media, or other cell or body fluids due to formation of a polydisulfide coating; can bind to a variety of metals through the available DMSA chelator ligands or to the iron oxide lattice;21 and this binding capability of DMSA includes iron, zinc, and silver 21, 22…”

Section: Resultsmentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticles (SPION) for the Treatment of Antibiotic‐Resistant Biofilms

Taylor

Kummer

Durmus

et al. 2012

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131

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Bacterial infections caused by antibiotic‐resistant strains are of deep concern due to an increasing prevalence, and are a major cause of morbidity in the United States of America. In particular, medical device failures, and thus human lives, are greatly impacted by infections, where the treatments required are further complicated by the tendency of pathogenic bacteria, such as Staphylococcus aureus, to produce antibiotic resistant biofilms. In this study, a panel of relevant antibiotics used clinically including penicillin, oxacillin, gentamicin, streptomycin, and vancomycin are tested, and although antibiotics are effective against free‐floating planktonic S. aureus, either no change in biofilm function is observed, or, more frequently, biofilm function is enhanced. As an alternative, superparamagnetic iron oxide nanoparticles (SPION) are synthesized through a two‐step process with dimercaptosuccinic acid as a chelator, followed by the conjugation of metals including iron, zinc, and silver; thus, the antibacterial properties of the metals are coupled to the superparamagnetic properties of SPION. SPION might be the ideal antibacterial treatment, with a superior ability to decrease multiple bacterial functions, target infections in a magnetic field, and had activity better than antibiotics or metal salts alone, as is required for the treatment of medical device infections for which no treatment exists today.

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Section: Resultsmentioning

confidence: 99%

Superparamagnetic Iron Oxide Nanoparticles (SPION) for the Treatment of Antibiotic‐Resistant Biofilms

Taylor

Kummer

Durmus

et al. 2012

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131

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“…There have been a number of reports dealing with the stability constants of metal complexes of DMSA or DMPS (17,18). It has been claimed that the greater the stability constant for a given metal ion complex, the greater the mobilization of that ion when the metal-binding agent is given (19).…”

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confidence: 99%

DMSA and DMPS-Water Soluble Antidotes for Heavy Metal Poisoning

Aposhian¹

1983

Annu. Rev. Pharmacol. Toxicol.

291

149

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This article reviews the pharmacological properties and the uses of two important antidotes for heavy metal poisoning. Meso-dimercaptosuccinic acid (DMSA) and 2,3-dimercapto-l-propanesulfonic acid, Na salt (DMPS) are relatively new antidotes-new, that is, to the western world. Although DMSA was introduced originally by Friedheim et al (1) to increase uptake of antimony during schistosomiasis therapy, Liang et al (77) at Shanghai in 1957 were the first to report its effectiveness as an antidote for heavy metallpoisoning. The synthesis and some of the metal binding properties of DMPS were reported in 1956 by Petrunkin from Kiev (3). Shortly thereafter, DMPS became an official drug in the Soviet Union, where it is known as Unithiol (4). Between 1956 and 1975, DMSA and DMPS were studied extensively, at both the basic science and clinical levels, in the People's Republic of China, the Soviet Union, and Japan. Some of these investigations have been cited and can be found in an earlier review (5). In the USA and western Europe, however, these two compounds received very little attention until recently. A paper by Friedheim & Corvi (6) in 1975, dealing with DMSA for the treatment of mercury poisoning, and the recent production and availability of DMPS from Heyl & Co., Berlin, stimulated investigators to "rediscover" and study these two metal-binding agents. DMSA and DMPS are water soluble chemical analogs of dimercaprol (British Anti-Lewisite, BAL). In contrast to BAL, they have less toxicity, greater water solubility, and limited lipid solubility, and are effective when given orally. * Important notes are marked. 193 If levels of heavy metals such as arsenic, lead, mercury, and cadmium continue to increase in the environment (7), the need will increase also for more effective, therapeutically useful antidotes to treat poisoning by these metals. This need might be met, in the future, by either DMSA, DMPS, or both. They are replacing BAL in the experimental laboratory and in some clinical situations, as discussed below. All of the papers published on DMSA and DMPS cannot be cited in this review. Space limitations have been imposed on an already lengthy bibliography. Many Chinese, Soviet, and Japanese papers have been translated, reviewed, and included. An emphasis has been placed, though, on important articles published since 1975. GENERAL AND CHEMICAL PROPERTIES DMSA and the sodium salt of DMPS are available as white crystalline powders. BAL is an oily liquid. Chemical formulas can be found in an earlier review (5). DMPS has been prepared as the racemic mixture (3), dextro-rotatory form and levo-rotatory form (W. Parr, personal communication). Studies using the D-or L-form, however are rare. In the literature and in this article, the abbreviation DMPS, unless otherwise stated, denotes the racemic mixture of the sodium salt of 2,3-dimercapto-l-propanesulfonic acid. Since DMSA has two asymmetric carbon atoms, the compound exists as the meso form and the DL form. Meso-DMSA is easier to prepare, more readily available, and h...

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Management of biofilm-associated infections in diabetic wounds – from bench to bedside

Bogadi,

Rao,

et al. 2024

Pure and Applied Chemistry

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Biofilms are complex bacterial colonies embedded in an extracellular matrix. These pose a major obstacle to wound healing and are noticeable in chronic wounds. It protects the bacteria from the host’s immune system and conventional antibiotic treatments. The biofilm’s protective matrix prevents essential nutrients and oxygen from diffusing into the surrounding healthy tissue. In addition, microbes living in biofilms naturally have increased resistance to antibiotics, which reduces the effectiveness of traditional therapies. As such, biofilms serve as persistent reservoirs of infection, which further disrupts the normal course of wound healing. In this review, the current formulation strategies such as hydrogels, polymeric nanoparticles, and nanofibers that are used in wound healing to counteract biofilms have been comprehensively discussed. The formulations have been meticulously designed and developed to disturb the biofilm matrix, prevent the growth of microorganisms, and increase the potency of antimicrobials and antibiotics. The mechanism of action, advantages and limitations associated with the existing formulation strategies have been reviewed. The formulation strategies that have been translated into clinical applications and patented are also discussed in this paper.

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Comparative study of the interaction of stereoisomers of dimercaptosuccinic acid with certain metals

Cited by 3 publications

References 2 publications

Superparamagnetic Iron Oxide Nanoparticles (SPION) for the Treatment of Antibiotic‐Resistant Biofilms

Superparamagnetic Iron Oxide Nanoparticles (SPION) for the Treatment of Antibiotic‐Resistant Biofilms

DMSA and DMPS-Water Soluble Antidotes for Heavy Metal Poisoning

Management of biofilm-associated infections in diabetic wounds – from bench to bedside

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