Comparative Study of the Physical, Topographical and Biological Properties of Electrospinning PCL, PLLA, their Blend and Copolymer Scaffolds

Bolbasov, E. N.; Goreninskii, S. I.; Tverdokhlebov, S. I.; Mishanin, Alexander I.; Викнянщук, А. Н.; Bezuidenhout, Deon; Головкин, А. С.

doi:10.1088/1757-899x/350/1/012012

Cited by 14 publications

(17 citation statements)

References 10 publications

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“… 52 , 53 However, this will be dependent on other factors such as crystallinity. The contact angle found for H100 is lower than results previously reported (123° 54 and 101° 55 ) for PCL of a similar molecular weight, although contact angle is dependent on factors such as surface properties. For example, a rough surface will result in a higher contact angle for hydrophobic materials but a lower contact angle for hydrophilic materials.…”

Section: Resultscontrasting

confidence: 77%

“…For example, a rough surface will result in a higher contact angle for hydrophobic materials but a lower contact angle for hydrophilic materials. 51,54,55 The addition of L-PCL has a significant (p < 0.05) effect in reducing the contact angle of the films (Figure 6A), thereby increasing the hydrophilicity of the films. Increasing the proportion of L-PCL above 30% did not have a significant (p > 0.05) effect on further decreasing the contact angle of the formulations.…”

Section: Resultsmentioning

confidence: 99%

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Poly(caprolactone)-Based Coatings on 3D-Printed Biodegradable Implants: A Novel Strategy to Prolong Delivery of Hydrophilic Drugs

et al. 2020

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Implantable devices are versatile and promising drug delivery systems, and their advantages are well established. Of these advantages, long-acting drug delivery is perhaps the most valuable. Hydrophilic compounds are particularly difficult to deliver for prolonged times. This work investigates the use of poly(caprolactone) (PCL)-based implant coatings as a novel strategy to prolong the delivery of hydrophilic compounds from implantable devices that have been prepared by additive manufacturing (AM). Hollow implants were prepared from poly(lactic acid) (PLA) and poly(vinyl alcohol) (PVA) using fused filament fabrication (FFF) AM and subsequently coated in a PCL-based coating. Coatings were prepared by solution-casting mixtures of differing molecular weights of PCL and poly(ethylene glycol) (PEG). Increasing the proportion of low-molecular-weight PCL up to 60% in the formulations decreased the crystallinity by over 20%, melting temperature by over 4 °C, and water contact angle by over 40°, resulting in an increased degradation rate when compared to pure high-molecular-weight PCL. Addition of 30% PEG to the formulation increased the porosity of the formulation by over 50% when compared to an equivalent PCL-only formulation. These implants demonstrated in vitro release rates for hydrophilic model compounds (methylene blue and ibuprofen sodium) ranging from 0.01 to 34.09 mg/day, depending on the drug used. The versatility of the devices produced in this work and the range of release rates achievable show great potential. Implants could be specifically developed in order to match the specific release rate required for a number of drugs for a wide range of conditions.

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Section: Resultscontrasting

confidence: 77%

Section: Resultsmentioning

confidence: 99%

Poly(caprolactone)-Based Coatings on 3D-Printed Biodegradable Implants: A Novel Strategy to Prolong Delivery of Hydrophilic Drugs

et al. 2020

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“…The adhesion of cells onto the surface of a material is a complex multistage process that depends mostly on the nature of the surface itself, including its chemical properties and topographical features [19,43]. The adhesion can proceed in three possible scenarios.…”

Section: Discussionmentioning

confidence: 99%

“…The biocompatibility of the materials (cell adhesion and viability) was determined as previously described [43] using MSCs from passages 4–5. Material samples measuring 12 × 8 mm were co-cultivated with MSCs in the wells of a 24-well plate for three and six days.…”

Section: Methodsmentioning

confidence: 99%

Electrospun Bilayer Chitosan/Hyaluronan Material and Its Compatibility with Mesenchymal Stem Cells

et al. 2019

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A bilayer nonwoven material for tissue regeneration was prepared from chitosan (CS) and hyaluronic acid (HA) by needleless electrospinning wherein 10–15 wt% (with respect to polysaccharide) polyethylene oxide was added as spinning starter. A fiber morphology study confirmed the material’s uniform defect-free structure. The roughness of the bilayer material was in the range of 1.5–3 μm, which is favorable for cell growth. Electrospinning resulted in the higher orientation of the polymer structure compared with that of corresponding films, and this finding may be related to the orientation of the polymer chains during the spinning process. These structural changes increased the intermolecular interactions. Thus, despite a high swelling degree of 1.4–2.8 g/g, the bilayer matrix maintained its shape due to the large quantity of polyelectrolyte contacts between the chains of oppositely charged polymers. The porosity of the bilayer CS–HA nonwoven material was twice lower, while the Young’s modulus and break stress were twice higher than that of a CS monolayer scaffold. Therefore, during the electrospinning of the second layer, HA may have penetrated into the pores of the CS layer, thereby increasing the polyelectrolyte contacts between the two polymers. The bilayer CS–HA scaffold exhibited good compatibility with mesenchymal stem cells. This characteristic makes the developed material promising for tissue engineering applications.

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“…The aims of the present study were to prepare electrospun bilayer scaffolds based on CS and CNW-containing ALG and to study their structure, morphology, and porosity. The adhesion and proliferation of human MMSCs, as a well-established testing model [ 13 , 34 ], were also determined to explore the biocompatibility of the prepared scaffolds.…”

Section: Introductionmentioning

confidence: 99%

Cytocompatibility of Bilayer Scaffolds Electrospun from Chitosan/Alginate-Chitin Nanowhiskers

et al. 2020

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In this work, a bilayer chitosan/sodium alginate scaffold was prepared via a needleless electrospinning technique. The layer of sodium alginate was electrospun over the layer of chitosan. The introduction of partially deacetylated chitin nanowhiskers (CNW) stabilized the electrospinning and increased the spinnability of the sodium alginate solution. A CNW concentration of 7.5% provided optimal solution viscosity and structurization due to electrostatic interactions and the formation of a polyelectrolyte complex. This allowed electrospinning of defectless alginate nanofibers with an average diameter of 200–300 nm. The overall porosity of the bilayer scaffold was slightly lower than that of a chitosan monolayer, while the average pore size of up to 2 μm was larger for the bilayer scaffold. This high porosity promoted mesenchymal stem cell proliferation. The cells formed spherical colonies on the chitosan nanofibers, but formed flatter colonies and monolayers on alginate nanofibers. The fabricated chitosan/sodium alginate bilayer material was deemed promising for tissue engineering applications.

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Comparative Study of the Physical, Topographical and Biological Properties of Electrospinning PCL, PLLA, their Blend and Copolymer Scaffolds

Cited by 14 publications

References 10 publications

Poly(caprolactone)-Based Coatings on 3D-Printed Biodegradable Implants: A Novel Strategy to Prolong Delivery of Hydrophilic Drugs

Poly(caprolactone)-Based Coatings on 3D-Printed Biodegradable Implants: A Novel Strategy to Prolong Delivery of Hydrophilic Drugs

Electrospun Bilayer Chitosan/Hyaluronan Material and Its Compatibility with Mesenchymal Stem Cells

Cytocompatibility of Bilayer Scaffolds Electrospun from Chitosan/Alginate-Chitin Nanowhiskers

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