Comparative study of theophylline and doxofylline in the treatment of stable chronic obstructive pulmonary disease

Nagawaram, Panduranga Rao; Kanchanpally, Vashishta

doi:10.18203/2319-2003.ijbcp20160464

Cited by 1 publication

(1 citation statement)

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“…However, another Indian study conducted in patients of COPD, that compared theophylline and doxofylline at doses recommended and commonly used in clinical practice, showed that both drugs significantly improved spirometric values and symptoms, cough, shortness of breath and nocturnal severity of symptoms. 48 The main factor limiting the use of theophylline in this study was the high incidence of side effects, especially gastric distress (33% in theophylline group and 15% in doxofylline group) and CNS stimulation.…”

Section: Doxofyllinementioning

confidence: 77%

Doxofylline is not just another theophylline!

Matera¹,

Page²,

Cazzola³

2017

COPD

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Doxofylline, which differs from theophylline in containing the dioxalane group at position 7, has comparable efficacy to theophylline in the treatment of respiratory diseases, but with an improved tolerability profile and a favorable risk-to-benefit ratio. Furthermore, it does not have significant drug–drug interactions as exhibited with theophylline, which make using theophylline more challenging, especially in elderly patients with co-morbidities receiving multiple classes of drug. It is now clear that doxofylline also possesses a distinct pharmacological profile from theophylline (no significant effect on any of the known phosphodiesterase isoforms, no significant adenosine receptor antagonism, no direct effect on histone deacetylases, interaction with β2-adrenoceptors) and therefore, should not be considered as just a modified theophylline. Randomized clinical trials of doxofylline to investigate the use of this drug to reduce exacerbations and hospitalizations due to asthma or COPD as an alternative to expensive biologics, and certainly as an alternative to theophylline are to be encouraged.

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Section: Doxofyllinementioning

confidence: 77%