Comparative study of tissue response to polyglecaprone 25, polyglactin 910 and polytetrafluorethylene suture materials in rats

Filho, Hugo Nary; Matsumoto, Mariza Akemi; Batista, Aline Carvalho; Lopes, Luís César; Góes, Fernanda Costa Grizzo de Sampaio; Consolaro, Alberto

doi:10.1590/s0103-64402002000200002

Cited by 37 publications

(6 citation statements)

References 8 publications

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“…Other rat studies have evaluated PDS II®, MONOCRYL®, VICRYL®, Chromic Gut® and e-PTFE®. Despite acceptance from the animals, VICRYL® suture showed the highest level of inflammation on histological evaluation [33, 34]. …”

Section: Discussionmentioning

confidence: 99%

Induction of immune gene expression and inflammatory mediator release by commonly used surgical suture materials: an experimental in vitro study

et al. 2017

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BackgroundSurgeons have a range of materials to choose from to complete wound closure, yet surprisingly very little is still known about the body’s immune response to the suture materials in current use. The growing literature of adverse suture material reactions provided the objective of this study, to use in vitro assays to quantify levels of inflammation produced by seven commonly used suture materials in surgical procedures.MethodsHuman monocyte/macrophage THP-1 cells were exposed to suture materials for 1, 3 and 5 days. Gene expression and protein secretion of six inflammatory cytokines and two cell surface markers were assessed using qPCR and ELISA respectively, with LPS exposure providing a positive control. Furthermore, a IL-1β/IL-1RA marker ratio was assessed to determine the balance between pro-/anti-inflammatory expression.ResultsThe findings from our in vitro study suggest that four commonly used suture materials cause upregulation of pro-inflammatory markers indicative of an early foreign body reaction, with no balance from anti-inflammatory markers.ConclusionsAs prolonged early pro-inflammation is known to produce delayed wound healing responses, the knowledge produced from this study has potential to improve informed surgical decision making and patient safety. This work has the capability to reduce suture-related adverse immune reactions, and therefore positively affect patient outcomes.

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Section: Discussionmentioning

confidence: 99%

Induction of immune gene expression and inflammatory mediator release by commonly used surgical suture materials: an experimental in vitro study

et al. 2017

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“…PG is a synthetic, absorbable, braided suture consisting of 90% glycolide and 10% L-lactide [8]. Poliglecaprone 25 monofilament suture material, a copolymer of glycolide and e-caprolactone, is absorbed by hydrolysis in a period of 91 to 119 days, has excellent strength, minimal memory, and a great deal of malleability [9]. Studies have examined the tensile strength and resorption rates of different suture materials, and it has been found that the tensile strength of sutures decreased over time and was dependent on the rate of resorption [4].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of tensile strength of surgical synthetic absorbable suture materials: an in vitro study

Khiste

Ranganath

Nichani

2013

J Periodontal Implant Sci

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PurposeThe purpose of this study was to evaluate the tensile strength of surgical synthetic absorbable sutures over a period of 14 days under simulated oral conditions.MethodsThree suture materials (polyglycolic acid [PGA], polyglactin [PG] 910, and poly (glycolide-co-є-caprolactone) [PGC]) were used in 4-0 and 5-0 gauges. 210 suture samples (35 of each material and gauge) were used. All of the samples were tested preimmersion and 1 hour and 1, 3, 7, 10, and 14 days postimmersion. The tensile strength of each suture material and gauge was assessed. The point of breakage and the resorption pattern of the sutures were also assessed.ResultsDuring the first 24 hours of immersion, all 4-0 and 5-0 samples of PGA, PG 910, and PGC maintained their initial tensile strength. At baseline (preimmersion), there was a statistically significant (P<0.001) difference in the tensile strengths between the 4-0 and 5-0 gauge of PGA, PG 910, and PGC. PGA 4-0 showed the highest tensile strength until day 10. At 7 days, all the 4-0 sutures of the three materials had maintained their tensile strength with PGA 4-0 having significantly greater (P=0.003) tensile strength compared to PG.Conclusions4-0 sutures are stronger and have greater tensile strength than 5-0 sutures. The PGA 4-0 suture showed the highest tensile strength at the end of day 10.

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“…In a study examining the tissue reactions of polyglactin 910, poliglecaprone 25 and polytetrafluoroethylene (PTFE) suture materials in Wistar albino rats, fibrosis, angioblastic and fibroblastic proliferations, and inflammation intensities were evaluated histologically on the 2nd, 7th, 14th and 21st days by optical microscopy. According to the results of the study, the frequency of tissue reaction was found to be in the following order: polilecaprone 25, polyglactin 910 and polytetrafluoroethylene [29]. When the studies were evaluated in general, it was observed that monofilament sutures caused less tissue reaction and inflammation than multifilament sutures.…”

Section: Discussionmentioning

confidence: 93%

Evaluation of the Effect of Polybutester and Polypropylene Sutures on Complications after Impacted Lower Third Molar Surgery

Orhan,

Ciğerim

2024

Applied Sciences

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Complications that can occur in the postoperative period of impacted lower third molar extraction are factors that have an impact on the daily routine of patients. This study aimed to evaluate the efficacy of polybutester and polypropylene sutures on postoperative complications after impacted lower third molar surgery. Two different suture materials were used in the 35 patients with bilateral impacted lower third molars included in the study: polybutester sutures in group 1 and polypropylene sutures in group 2. Measurements were taken to evaluate swelling and trismus before surgery and on the 2nd and 7th days after surgery, and pain was evaluated using a visual analogue scale (VAS), which patients were asked to complete after surgery. Wound healing, suture-related injury and suture-related discomfort in patients were also evaluated. The pain and suture-related discomfort felt on the side where the polybutester suture was used was less on the second postoperative day than on the side where the polypropylene suture was used. These results support the use of polybutester sutures in impacted third molar surgery.

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Comparative study of tissue response to polyglecaprone 25, polyglactin 910 and polytetrafluorethylene suture materials in rats

Cited by 37 publications

References 8 publications

Induction of immune gene expression and inflammatory mediator release by commonly used surgical suture materials: an experimental in vitro study

Induction of immune gene expression and inflammatory mediator release by commonly used surgical suture materials: an experimental in vitro study

Evaluation of tensile strength of surgical synthetic absorbable suture materials: an in vitro study

Evaluation of the Effect of Polybutester and Polypropylene Sutures on Complications after Impacted Lower Third Molar Surgery

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